Role of immune cells in salt-sensitive hypertension and renal injury

Abstract

Purpose of review: Immune mechanisms exacerbate the severity of hypertension in humans and animal models of disease. This review summarizes recent mechanistic studies exploring the pathways whereby immunity influences salt-sensitive hypertension and renal disease.

Recent findings: Emphasis is placed on the role of T cell subtypes, the mechanisms of T-cell activation, and the identification of potential antigens or neoantigens.

Summary: Significant advancements have occurred in the search for pathways which activate the adaptive immune response. An enhanced understanding of the factors contributing to hypertension can lead to better therapies.

Conflict of interest statement

Conflicts of Interest

None

Figures

Figure 1

Proposed stimuli and mechanisms of action of immune cells in salt-sensitive hypertension.