Prevalence and correlates of chronic obstructive pulmonary disease and chronic respiratory symptoms in rural southwestern Uganda: a cross-sectional, population-based study

Crystal M North, Bernard Kakuhikire, Dagmar Vořechovská, Simone Hausammann-Kigozi, Amy Q McDonough, Jordan Downey, David C Christiani, Alexander C Tsai, Mark J Siedner, Crystal M North, Bernard Kakuhikire, Dagmar Vořechovská, Simone Hausammann-Kigozi, Amy Q McDonough, Jordan Downey, David C Christiani, Alexander C Tsai, Mark J Siedner

Abstract

Background: The global burden of chronic obstructive pulmonary disease (COPD) disproportionately affects resource-limited settings such as sub-Saharan Africa (SSA), but population-based prevalence estimates in SSA are rare. We aimed to estimate the population prevalence of COPD and chronic respiratory symptoms in rural southwestern Uganda.

Methods: Adults at least 18 years of age who participated in a population-wide census in rural southwestern Uganda completed respiratory questionnaires and lung function testing with bronchodilator challenge at health screening events in June 2015. We defined COPD as post-bronchodilator forced expiratory volume in one second to forced vital capacity ratio less than the lower limit of normal. We fit multivariable linear and log binomial regression models to estimate correlates of abnormal lung function and respiratory symptoms, respectively. We included inverse probability of sampling weights in models to facilitate population-level estimates.

Results: Forty-six percent of census participants (843/1814) completed respiratory questionnaires and spirometry, of which 565 (67%) met acceptability standards. COPD and respiratory symptom population prevalence were 2% (95% confidence interval (CI) = 1%-3%) and 30% (95% CI = 25%-36%), respectively. Respiratory symptoms were more prevalent and lung function was lower among women and ever-smokers (P < 0.05). HIV serostatus was associated with neither respiratory symptoms nor lung function.

Conclusions: COPD population prevalence was low despite prevalent respiratory symptoms. This work adds to the growing body of literature depicting lower-than-expected COPD prevalence estimates in SSA and raises questions about whether the high respiratory symptom burden in rural southwestern Uganda represents underlying structural lung disease not identified by screening spirometry.

Conflict of interest statement

Competing interests: The authors completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available upon request from the corresponding author) and declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flow diagram of participant selection. Flow diagram describing the number of eligible participants in the target region, how many eligible participants sought screening at the health fair, and how many of those who sought screening completed respiratory questionnaires and American Thoracic Society (ATS)-acceptable pulmonary function testing. Those who completed respiratory questionnaires and ATS-acceptable pulmonary function testing were used to calculate respiratory symptom burden and COPD prevalence estimates, respectively.

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