Epidemiological evidence for a common mechanism for neuroblastoma and differentiated thyroid tumour
F de Vathaire, P François, M Schlumberger, O Schweisguth, C Hardiman, E Grimaud, O Oberlin, C Hill, J Lemerle, R Flamant, F de Vathaire, P François, M Schlumberger, O Schweisguth, C Hardiman, E Grimaud, O Oberlin, C Hill, J Lemerle, R Flamant
Abstract
Because genetic predisposition probably plays an important role in the aetiology of most of childhood cancers, studies of second primaries occurring after these cancers may be particularly informative about possible common genetic mechanisms in both of these cancers. We have studied the incidence of thyroid tumours occurring after cancer in childhood in a cohort of 592 children treated before 1970. Among these children, six later developed a thyroid carcinoma, and 18 developed a thyroid adenoma. Radiation doses received to the thyroid by each of the irradiated children have been estimated using individual radiotherapeutic technical records. Thyroid carcinomas and thyroid adenomas were five times more frequent after irradiation for neuroblastoma than after irradiation for any other first cancer. This ratio did not depend on sex, nor on time elapsed since irradiation, nor on dose of radiation received for the thyroid gland. This result suggests that there is a common mechanism for the occurrence of neuroblastoma and of differentiated thyroid tumour.
References
- Med Phys. 1988 Nov-Dec;15(6):879-83
- N Engl J Med. 1987 Sep 3;317(10):588-93
- C R Seances Acad Sci III. 1981 May 11;292(17):999-1004
- Cancer Res. 1991 Jun 1;51(11):2885-8
- Br J Cancer. 1987 Sep;56(3):339-47
- Br J Cancer. 1989 Mar;59(3):448-52
- Proc Natl Acad Sci U S A. 1985 Sep;82(18):6216-20
- J Natl Cancer Inst. 1985 Jun;74(6):1177-84
- JAMA. 1990 Aug 1;264(5):581-4
- Cancer. 1990 Sep 15;66(6):1213-20
- Br J Cancer. 1989 May;59(5):792-6
- Lancet. 1988 Aug 20;2(8608):455
- Med Phys. 1988 May-Jun;15(3):328-33
Source: PubMed