Preservation versus nonpreservation of the left colic artery in anterior resection for rectal cancer: a propensity score-matched analysis

Huichao Zheng, Fan Li, Xingjie Xie, Song Zhao, Bin Huang, Weidong Tong, Huichao Zheng, Fan Li, Xingjie Xie, Song Zhao, Bin Huang, Weidong Tong

Abstract

Background: Preserving the left colic artery (LCA) during anterior resection for rectal cancer is controversial, and robust evidence of the outcomes of LCA preservation plus apical lymph node dissection is lacking. The purpose of this study was to investigate the impact of LCA preservation plus apical lymph node dissection surgery on anastomotic leakage and number of harvested lymph nodes.

Methods: Patients who underwent laparoscopic or robotic anterior resection for rectal cancer between September 2017 and May 2020 were retrospectively assessed. The patients were categorized into two groups: preservation of LCA and nonpreservation of LCA. A one-to-one propensity score-matched analysis was performed to decrease confounding. The primary outcome was anastomotic leakage within 30 days after surgery. The secondary outcomes were number of harvested lymph nodes, 3-year overall survival, and 3-year disease-free survival.

Results: A total of 216 patients were eligible for this study, and propensity score matching yielded 60 patients in each group. Anastomotic leakage in the LCA preservation group was significantly lower than that in the LCA nonpreservation group (3.3% vs. 13.3%, P = 0.048). No significant differences were observed in blood loss, operation time, intraoperative complications, splenic flexure mobilization, total number of harvested lymph nodes, number of positive lymph nodes, time to first flatus, or postoperative hospital stay. Kaplan-Meier survival analysis showed a 3-year disease-free survival of 85.7% vs. 80.5% (P = 0.738) and overall survival of 92.4% vs. 93.7% (P = 0.323) for the preservation and nonpreservation groups, respectively.

Conclusion: LCA preservation plus apical lymph node dissection surgery for rectal cancer may help reduce the incidence of anastomotic leakage without impairing the number of harvested lymph nodes. Preliminary results suggest that 3-year disease-free survival and overall survival rates may not differ between the two types of surgery, but studies with larger sample sizes are needed to confirm these conclusions. Trial registration ClinicalTrials.gov, NCT03776370. Registered 14 December 2018-Retrospectively registered, https://clinicaltrials.gov .

Keywords: Anastomotic leakage; Anterior resection; Inferior mesenteric artery; Left colic artery; Rectal cancer; Surgery.

Conflict of interest statement

This study has no competing interests with any organization or individual.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
CONSORT flow chart of the study. LCA left colic artery
Fig. 2
Fig. 2
Preservation or nonpreservation of the left colic artery in anterior resection for rectal cancer. a Preservation of the left colic artery: the IMA was ligated below the origin of the LCA; b Nonpreservation of the left colic artery: the IMA was ligated 1 cm from its origin. IMA inferior mesenteric artery; LCA left colic artery; IMV inferior mesenteric vein
Fig. 3
Fig. 3
Oncological outcomes. a There was no significant difference in disease-free survival between the two groups (P = 0.738; log-rank test). b There was no significant difference in overall survival between the two groups (P = 0.323; log-rank test). LCA left colic artery

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