Effect of dexmedetomidine on intraoperative Surgical Pleth Index in patients undergoing video-assisted thoracoscopic lung lobectomy

Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji, Yu-Lan Wang, Xiao-Qi Kong, Fu-Hai Ji

Abstract

Background: The Surgical Pleth Index (SPI) is a monitoring method that reflects painful stimuli during general anesthesia, and dexmedetomidine is an analgesic adjuvant with an opioid-sparing effect. But up to now, it is still unclear whether dexmedetomidine has any influence on SPI. To investigate whether dexmedetomidine has an effect on SPI during video-assisted thoracoscopic surgery.

Methods: We enrolled 94 patients who underwent video-assisted thoracoscopic lung lobectomy. Patients were randomly assigned to a dexmedetomidine group (dexmedetomidine: 0.8 μg/kg administered for 10 min before anesthesia) or normal saline group (equal volume of normal saline). SPI and vital signs were recorded. The number rating scale (NRS) pain score was also evaluated.

Results: SPI values were significantly lower in the dexmedetomidine group than in the normal saline group at intubation and at discharge from the postanesthesia care unit. Compared with the normal saline group, mean arterial pressure and heart rate were both significantly lower in the dexmedetomidine group at intubation. Heart rate was lower at skin incision in the dexmedetomidine group. The NRS score in the normal saline group was noticeably higher vs. the dexmedetomidine group at discharge from the postanesthesia care unit.

Conclusions: Dexmedetomidine decreased intraoperative SPI and NRS scores. Our results showed that dexmedetomidine attenuated noxious stimuli.

Trial registration: Chinese Clinical Trial Registry (ChiCTR): ChiCTR-OOC-16009450 , Registered 16 October, 2016.

Keywords: Dexmedetomidine; Number rating scale; Surgical Pleth index; Thoracoscopic lung lobectomy.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Comparison of SPI values between the two groups undergoing video-assisted thoracoscopic lung lobectomy from the time patients entered the operating room to when they left the recovery room. SPI: Surgical Pleth Index, PACU: post anesthesia care unit, *P < 0.05
Fig. 2
Fig. 2
Hemodynamic changes in both groups. a Mean blood pressure at different time points, b Heart rate at different time points. PACU: post anesthesia care unit, *P < 0.05
Fig. 3
Fig. 3
Comparison of postoperative NRS pain scores between the two groups from when they left the recovery room to 48 h after surgery. NRS: number rating scale, PACU: post anesthesia care unit, *P < 0.05

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