Traditional Risk Factors for Stroke in East Asia

Young Dae Kim, Yo Han Jung, Gustavo Saposnik, Young Dae Kim, Yo Han Jung, Gustavo Saposnik

Abstract

Stroke is one of the leading causes of death and morbidity worldwide. The occurrence of stroke is strongly dependent on well-known vascular risk factors. After rapid modernization, urbanization, and mechanization, East Asian countries have experienced growth in their aged populations, as well as changes in lifestyle and diet. This phenomenon has increased the prevalence of vascular risk factors among Asian populations, which are susceptible to developing cardiovascular risk factors. However, differing patterns of stroke risk factor profiles have been noted in East Asian countries over the past decades. Even though the prevalence of vascular risk factors has changed, hypertension is still prevalent and the burden of diabetes and hypercholesterolemia will continue to increase. Asia remains a high tobacco-consuming area. Although indicators of awareness and management of vascular risk factors have increased in many East Asian countries, their rates still remain low. Here we review the burdens of traditional risk factors, such as hypertension, diabetes, hypercholesterolemia, and smoking in East Asia. We will also discuss the different associations between these vascular risk factors and stroke in Asian and non-Asian populations.

Keywords: Asia; Epidemiology; Risk factors; Stroke.

Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Figure 1.
Figure 1.
Trends in age-standardized mean systolic blood pressure (mmHg) for men (A) and women (B).
Figure 2.
Figure 2.
Trends in age-standardized mean fasting blood glucose (mmol/L) for men (A) and women (B).
Figure 3.
Figure 3.
Trends in age-standardized mean total cholesterol (mmol/L) for men (A) and women (B).
Figure 4.
Figure 4.
Trends in age-standardized prevalence (%) of daily tobacco smoking for men (A) and women (B).
Figure 5.
Figure 5.
Trends in age-standardized incidence rate (per 100,000 people) of total stroke (A), ischemic stroke (B), and hemorrhagic stroke (C).

References

    1. Murray CJL, Vos T, Lozano R, Naghavi M, Flaxman AD, Michaud C, et al. Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2197–2223.
    1. World Health Organization WHO Health statistics and information systems. (assessed Aug 10, 2015)
    1. Feigin VL, Lawes CM, Bennett DA, Barker-Collo SL, Parag V. Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009;8:355–369.
    1. Krishnamurthi RV, Feigin VL, Forouzanfar MH, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet Glob Health. 2013;1:e259–281.
    1. Ueshima H, Sekikawa A, Miura K, Turin TC, Takashima N, Kita Y, et al. Cardiovascular disease and risk factors in Asia: a selected review. Circulation. 2008;118:2702–2709.
    1. Mehndiratta MM, Khan M, Mehndiratta P, Wasay M. Stroke in Asia: geographical variations and temporal trends. J Neurol Neurosurg Psychiatry. 2014;85:1308–1312.
    1. Enkh-Oyun T, Kotani K, Davaalkham D, Uehara R, Sadakane A, Aoyama Y, et al. Hypertension in Mongolia: an overview. Ethn Dis. 2013;23:363–368.
    1. Choi YJ, Cho YM, Park CK, Jang HC, Park KS, Kim SY, et al. Rapidly increasing diabetes-related mortality with socio-environmental changes in South Korea during the last two decades. Diabetes Res Clin Pract. 2006;74:295–300.
    1. Kim S, Moon S, Popkin BM. The nutrition transition in South Korea. Am J Clin Nutr. 2000;71:44–53.
    1. Okayama A, Ueshima H, Marmot MG, Nakamura M, Kita Y, Yamakawa M. Changes in total serum cholesterol and other risk factors for cardiovascular disease in Japan, 1980–1989. Int J Epidemiol. 1993;22:1038–1047.
    1. Shintani TT, Hughes CK. Traditional diets of the Pacific and coronary heart disease. J Cardiovasc Risk. 1994;1:16–20.
    1. Ma RC, Chan JC. Type 2 diabetes in East Asians: Similarities and differences with populations in Europe and the United States. Ann N Y Acad Sci. 2013;1281:64–91.
    1. Yoon KH, Lee JH, Kim JW, Cho JH, Choi YH, Ko SH, et al. Epidemic obesity and type 2 diabetes in Asia. Lancet. 2006;368:1681–1688.
    1. Wang L, Kong L, Wu F, Bai Y, Burton R. Preventing chronic diseases in China. Lancet. 2005;366:1821–1824.
    1. Chan JC, Malik V, Jia W, Kadowaki T, Yajnik CS, Yoon KH, et al. Diabetes in Asia: epidemiology, risk factors, and pathophysiology. JAMA. 2009;301:2129–2140.
    1. Woodward M, Huxley R, Ueshima H, Fang X, Kim HC, Lam TH. The Asia Pacific Cohort Studies Collaboration: a decade of achievements. Global Heart. 2012;7:343–351.
    1. Khan NA, Quan H, Hill MD, Pilote L, McAlister FA, Palepu A, et al. Risk factors, quality of care and prognosis in South Asian, East Asian and White patients with stroke. BMC Neurol. 2013;13:74.
    1. Danaei G, Finucane MM, Lin JK, Singh GM, Paciorek CJ, Cowan MJ, et al. National, regional, and global trends in systolic blood pressure since 1980: systematic analysis of health examination surveys and epidemiological studies with 786 country-years and 5.4 million participants. Lancet. 2011;377:568–577.
    1. Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet. 2011;378:31–40.
    1. Farzadfar F, Finucane MM, Danaei G, Pelizzari PM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in serum total cholesterol since 1980: systematic analysis of health examination surveys and epidemiological studies with 321 country-years and 3.0 million participants. Lancet. 2011;377:578–586.
    1. Ng M, Freeman MK, Fleming TD, Robinson M, Dwyer-Lindgren L, Thomson B, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980-2012. JAMA. 2014;311:183–192.
    1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. Global burden of hypertension: analysis of worldwide data. Lancet. 2005;365:217–223.
    1. Lawes CM, Vander Hoorn S, Law MR, Elliott P, MacMahon S, Rodgers A. Blood pressure and the global burden of disease 2000. Part 1: Estimates of blood pressure levels. J Hypertens. 2006;24:413–422.
    1. Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. Worldwide prevalence of hypertension: a systematic review. J Hypertens. 2004;22:11–19.
    1. Ueshima H. Explanation for the Japanese paradox: Prevention of increase in coronary heart disease and reduction in stroke. J Atheroscler Thromb. 2007;14:278–286.
    1. Miura K, Nagai M, Ohkubo T. Epidemiology of hypertension in Japan: where are we now? Circ J. 2013;77:2226–2231.
    1. Korea Center For Disease Control & Prevention MoHW Korea health statistics 2014: Korea National Health and Nutrition Examination Survey (KNHANES VI)
    1. Su TC, Bai CH, Chang HY, You SL, Chien KL, Chen MF, et al. Evidence for improved control of hypertension in Taiwan: 1993-2002. J Hypertens. 2008;26:600–606.
    1. Wu X, Duan X, Gu D, Hao J, Tao S, Fan D. Prevalence of hypertension and its trends in Chinese populations. Int J Cardiol. 1995;52:39–44.
    1. Wu Y, Huxley R, Li L, Anna V, Xie G, Yao C, et al. Prevalence, awareness, treatment, and control of hypertension in China: data from the China National Nutrition and Health Survey 2002. Circulation. 2008;118:2679–2686.
    1. Gao Y, Chen G, Tian H, Lin L, Lu J, Weng J, et al. Prevalence of hypertension in China: a cross-sectional study. PLoS ONE. 2013;8:
    1. Public health institute: Mongolian STEPS survey on the prevalence of noncommunicable disease and injury risk factors-2009. Ministry of health; Mongolia: 2009.
    1. Public health institute: Mongolian STEPS survey on the prevalence of noncommunicable disease and injury risk factors-2006. Ministry of health; Mongolia: 2006.
    1. Ma YQ, Mei WH, Yin P, Yang XH, Rastegar SK, Yan JD. Prevalence of hypertension in Chinese cities: a meta-analysis of published studies. PLoS ONE. 2013;8:
    1. Fang L, Song J, Ma Z, Zhang L, Jing C, Chen D. Prevalence and characteristics of hypertension in mainland Chinese adults over decades: a systematic review. J Hum Hypertens. 2014;28:649–656.
    1. Hong KS, Bang OY, Kang DW, Yu KH, Bae HJ, Lee JS, et al. Stroke statistics in Korea: Part i. Epidemiology and risk factors: a report from the Korean Stroke Society and Clinical Research Center for Stroke. J Stroke. 2013;15:2–20.
    1. Nguyen HN, Fujiyoshi A, Abbott RD, Miura K. Epidemiology of cardiovascular risk factors in Asian countries. Cir J. 2013;77:2851–2859.
    1. Gu D, Reynolds K, Wu X, Chen J, Duan X, Muntner P, et al. Prevalence, awareness, treatment, and control of hypertension in China. Hypertension. 2002;40:920–927.
    1. Gregg EW, Cadwell BL, Cheng YJ, Cowie CC, Williams DE, Geiss L, et al. Trends in the prevalence and ratio of diagnosed to undiagnosed diabetes according to obesity levels in the U.S. Diabetes Care. 2004;27:2806–2812.
    1. Yang W, Lu J, Weng J, Jia W, Ji L, Xiao J, et al. Prevalence of diabetes among men and women in China. N Engl J Med. 2010;362:1090–1101.
    1. Xu Y, Wang L, He J, et al. Prevalence and control of diabetes in Chinese adults. JAMA. 2013;310:948–959.
    1. Jiang YD, Chang CH, Tai TY, Chen JF, Chuang LM. Incidence and prevalence rates of diabetes mellitus in Taiwan: analysis of the 2000-2009 Nationwide Health Insurance database. J Formos Med Assoc. 2012;111:599–604.
    1. Suvd J, Gerel B, Otgooloi H, Purevsuren D, Zolzaya H, Roglic G, et al. Glucose intolerance and associated factors in Mongolia: results of a national survey. Diabet Med. 2002;19:502–508.
    1. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract. 2014;103:137–149.
    1. Dickinson S, Colagiuri S, Faramus E, Petocz P, Brand-Miller JC. Postprandial hyperglycemia and insulin sensitivity differ among lean young adults of different ethnicities. J Nutr. 2002;132:2574–2579.
    1. Li H, Oldenburg B, Chamberlain C, O’Neil A, Xue B, Jolley D, et al. Diabetes prevalence and determinants in adults in China mainland from 2000 to 2010: a systematic review. Diabetes Res Clin Pract. 2012;98:226–235.
    1. Yamada M, Wong FL, Kodama K, Sasaki H, Shimaoka K, Yamakido M. Longitudinal trends in total serum cholesterol levels in a Japanese cohort, 1958-1986. J Clin Epidemiol. 1997;50:425–434.
    1. Li YH, Li Y, Davis CE, Chen Z, Tao S, Folsom AR, et al. Serum cholesterol changes from 1983-1984 to 1993-1994 in the People’s Republic of China. Nutr Metab Cardiovasc Dis. 2002;12:118–126.
    1. Jee SH, Appel LJ, Suh I, Whelton PK, Kim IS. Prevalence of cardiovascular risk factors in South Korean adults: results from the Korea Medical Insurance Corporation (KMIC) study. Ann Epidemiol. 1998;8:14–21.
    1. Wakugami K, Iseki K, Kimura Y, Okumura K, Ikemiya Y, Muratani H, et al. Relationship between serum cholesterol and the risk of acute myocardial infarction in a screened cohort in Okinawa, Japan. Jpn Circ J. 1998;62:7–14.
    1. Chen Z, Peto R, Collins R, MacMahon S, Lu J, Li W. Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ. 1991;303:276–282.
    1. Enkh-Oyun T, Kotani K, Swanson E. Ischemic heart disease among the general Mongolian population: a review of epidemiological studies. Int Health. 2016;8:13–17.
    1. Tseng LN, Tseng YH, Jiang YD, Chang CH, Chung CH, Lin BJ, et al. Prevalence of hypertension and dyslipidemia and their associations with micro- and macrovascular diseases in patients with diabetes in Taiwan: an analysis of nationwide data for 2000-2009. J Formos Med Assoc. 2012;111:625–636.
    1. Zhou B, Rao X, Dennis BH, Li Y, Zhuo Q, Folsom AR, et al. The relationship between dietary factors and serum lipids in chinese urban and rural populations of Beijing and Guangzhou. PRC-USA Cardiovascular and Cardiopulmonary Research group. Int J Epidemiol. 1995;24:528–534.
    1. Popkin BM, Horton S, Kim S, Mahal A, Shuigao J. Trends in diet, nutritional status, and diet-related noncommunicable diseases in China and India: the economic costs of the nutrition transition. Nutrition Reviews. 2001;59:379–390.
    1. Ueshima H, Iida M, Shimamoto T, Konishi M, Tanigaki M, Doi M, et al. Dietary intake and serum total cholesterol level: their relationship to different lifestyles in several Japanese populations. Circulation. 1982;66:519–526.
    1. Wu Y. Overweight and obesity in China: The once lean giant has a weight problem that is increasing rapidly. BMJ. 2006;333:362–363.
    1. Kim DM, Ahn CW, Nam SY. Prevalence of obesity in Korea. Obes Rev. 2005;6:117–121.
    1. Kim HM, Park J, Kim HS, Kim DH, Park SH. Obesity and cardiovascular risk factors in Korean children and adolescents aged 10-18 years from the Korean National Health and Nutrition Examination Survey, 1998 and 2001. Am J Epidemiol. 2006;164:787–793.
    1. Yatsuya H, Yamagishi K, Iso H. Adiposity and risk of cardiovascular diseases in Japan: secular trend, individual level associations and causal pathway - implications for the prevention of cardiovascular diseases in societies with rapid economic development. EPMA J. 2011;2:65–73.
    1. Li Q, Hsia J, Yang G. Prevalence of smoking in China in 2010. N Engl J Med. 2011;364:2469–2470.
    1. Katanoda K, Jiang Y, Park S, Lim MK, Qiao YL, Inoue M. Tobacco control challenges in East Asia: proposals for change in the world’s largest epidemic region. Tobacco Control. 2014;23:359–368.
    1. Chen Z, Peto R, Zhou M, Iona A, Smith M, Yang L, et al. Contrasting male and female trends in tobacco-attributed mortality in China: evidence from successive nationwide prospective cohort studies. Lancet. 2015;386:1447–1456.
    1. Li H, Ge J. Cardiovascular diseases in China: current status and future perspectives. IJC Heart & Vasculature. 2015;6:25–31.
    1. Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA, et al. Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010. Lancet. 2014;383:245–254.
    1. Lawes CM, Rodgers A, Bennett DA, Parag V, Suh I, Ueshima H, et al. Blood pressure and cardiovascular disease in the Asia Pacific region. J Hypertens. 2003;21:707–716.
    1. Martiniuk AL, Lee CM, Lawes CM, Ueshima H, Suh I, Lam TH, et al. Hypertension: its prevalence and population-attributable fraction for mortality from cardiovascular disease in the Asia-Pacific region. J Hypertens. 2007;25:73–79.
    1. Hyun KK, Huxley RR, Arima H, Woo J, Lam TH, Ueshima H, et al. A comparative analysis of risk factors and stroke risk for Asian and non-Asian men: the Asia Pacific Cohort Studies Collaboration. Int J Stroke. 2013;8:606–611.
    1. Woodward M, Huxley H, Lam TH, Barzi F, Lawes CM, Ueshima H, et al. A comparison of the associations between risk factors and cardiovascular disease in Asia and Australasia. Eur J Cardiovasc Prev Rehabil. 2005;12:484–491.
    1. Perkovic V, Huxley R, Wu Y, Prabhakaran D, MacMahon S. The burden of blood pressure-related disease: a neglected priority for global health. Hypertension. 2007;50:991–997.
    1. Chen X, Zhou L, Zhang Y, Yi D, Liu L, Rao W, et al. Risk factors of stroke in Western and Asian countries: a systematic review and meta-analysis of prospective cohort studies. BMC Public Health. 2014;14:776.
    1. Feigin VL, Roth GA, Naghavi M, Parmar P, Krishnamurthi R, Chugh S, et al. Global burden of stroke and risk factors in 188 countries, during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet Neurol. 2016;15:913–924.
    1. O’Donnell MJ, Chin SL, Rangarajan S, Xavier D, Liu L, Zhang H, et al. Global and regional effects of potentially modifiable risk factors associated with acute stroke in 32 countries (INTERSTROKE): a case-control study. Lancet. 2016;388:761–775.
    1. Kubo M, Hata J, Doi Y, Tanizaki Y, Iida M, Kiyohara Y. Secular trends in the incidence of and risk factors for ischemic stroke and its subtypes in Japanese population. Circulation. 2008;118:2672–2678.
    1. Park TH, Ko Y, Lee SJ, Lee KB, Lee J, Han MK, et al. Identifying target risk factors using population attributable risks of ischemic stroke by age and sex. J Stroke. 2015;17:302–311.
    1. Jung KH, Lee SH, Kim BJ, Yu KH, Hong KS, Lee BC, et al. Secular trends in ischemic stroke characteristics in a rapidly developed country: results from the Korean Stroke Registry Study (secular trends in Korean stroke) Circ Cardiovasc Qual Outcomes. 2012;5:327–334.
    1. Kim YD, Choi HY, Cho HJ, Cha MJ, Nam CM, Han SW, et al. Increasing frequency and burden of cerebral artery atherosclerosis in Korean stroke patients. Yonsei Med J. 2010;51:318–325.
    1. Uchiyama S. Impact of metabolic syndrome as a risk factor for atherothrombotic stroke. Intern Med. 2005;44:1021–1022.
    1. Kim YD, Choi HY, Jung YH, Nam CM, Yang JH, Cho HJ, et al. Classic risk factors for atherosclerosis are not major determinants for location of extracranial or intracranial cerebral atherosclerosis. Neuroepidemiology. 2009;32:201–207.
    1. Kim JS, Nah HW, Park SM, Kim SK, Cho KH, Lee J, et al. Risk factors and stroke mechanisms in atherosclerotic stroke: intracranial compared with extracranial and anterior compared with posterior circulation disease. Stroke. 2012;43:3313–3318.
    1. Su TC, Bai CH, Chang HY, You SL, Chien KL, Chen MF, et al. Evidence for improved control of hypertension in Taiwan: 1993-2002. J Hypertens. 2008;26:600–606.
    1. Xu Y, Wang L, He J, Bi Y, Li M, Wang T. Prevalence and control of diabetes in Chinese adults. JAMA. 2013;310:948–959.
    1. Wu L, He Y, Jiang B, Sun D, Wang J, Liu M, et al. Trends in prevalence, awareness, treatment and control of hypertension during 2001-2010 in an urban elderly population of China. PLoS ONE. 2015;10:
    1. Joffres M, Falaschetti E, Gillespie C, Robitaille C, Loustalot F, Poulter N. Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study. BMJ open. 2013;3:
    1. Ottawa C, Sposato LA, Nabbouh F, Saposnik G, Stroke Outcomes Research C Stroke preparedness in children: Translating knowledge into behavioral intent: a systematic review and meta-analysis. Int J Stroke. 2015;10:1008–1013.
    1. Chang FC, Chung CH, Yu PT, Chao KY. The impact of graphic cigarette warning labels and smoke-free law on health awareness and thoughts of quitting in Taiwan. Health Educ Res. 2011;26:179–191.
    1. Bang OY, Hong KS, Heo JH, Koo J, Kwon SU, Yu KH, et al. New oral anticoagulants may be particularly useful for Asian stroke patients. J Stroke. 2014;16:73–80.
    1. Goldstein LB, Bushnell CD, Adams RJ, Appel LJ, Braun LT, Chaturvedi S, et al. Guidelines for the primary prevention of stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2011;42:517–584.
    1. Ikeda N, Sapienza D, Guerrero R, Aekplakorn W, Naghavi M, Mokdad AH, et al. Control of hypertension with medication: a comparative analysis of national surveys in 20 countries. Bull World Health Organ. 2014;92:10–19C.
    1. Tanaka T, Okamura T, Yamagata Z, Takebayashi T, Tamura U, Kusaka Y, et al. Awareness and treatment of hypertension and hypercholesterolemia in Japanese workers: The High-Risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) study. Hypertens Res. 2007;30:921–928.
    1. Pan WH, Chang HY, Yeh WT, Hsiao SY, Hung YT. Prevalence, awareness, treatment and control of hypertension in Taiwan: Results of Nutrition and Health Survey in Taiwan (NAHSIT) 1993-1996. J Hum Hypertens. 2001;15:793–798.
    1. Yamamoto Y, Sonoyama K, Matsubara K, Furuse M, Yatsuhashi T, Hamada T, et al. The status of hypertension management in Japan in 2000. Hypertens Res. 2002;25:717–725.
    1. Konta T, Ikeda A, Ichikawa K, Fujimoto S, Iseki K, Moriyama T, et al. Blood pressure control in a Japanese population with chronic kidney disease: a baseline survey of a nationwide cohort. Am J Hypertens. 2012;25:342–347.
    1. Hu D, Fu P, Xie J, Chen CS, Yu D, Whelton PK, et al. Increasing prevalence and low awareness, treatment and control of diabetes mellitus among Chinese adults: the interASIA study. Diabetes Res Clin Pract. 2008;81:250–257.
    1. Pan WH, Yeh WT, Chang HY, Hwu CM, Ho LT. Prevalence and awareness of diabetes and mean fasting glucose by age, sex, and region: results from the Nutrition and Health Survey in Taiwan, 1993-1996. Diabet Med. 2003;20:182–185.
    1. Kobayashi M, Yamazaki K, Hirao K, Oishi M, Kanatsuka A, Yamauchi M, et al. The status of diabetes control and antidiabetic drug therapy in Japan--a cross-sectional survey of 17,000 patients with diabetes mellitus (JDDM 1) Diabetes Res Clin Pract. 2006;73:198–204.
    1. Arai K, Hirao K, Matsuba I, Takai M, Matoba K, Takeda H, et al. The status of glycemic control by general practitioners and specialists for diabetes in Japan: a cross-sectional survey of 15,652 patients with diabetes mellitus. Diabetes Res Clin Pract. 2009;83:397–401.
    1. Chuang LM, Tsai ST, Huang BY, Tai TY, Diabcare-Asia Study G The status of diabetes control in Asia--a cross-sectional survey of 24 317 patients with diabetes mellitus in 1998. Diabet Med. 2002;19:978–985.
    1. Lin SD, Tsai ST, Tu ST, Su CC, Chen JF, Lu CH, et al. Glycosylated hemoglobin level and number of oral antidiabetic drugs predict whether or not glycemic target is achieved in insulin-requiring type 2 diabetes. Prim Care Diabetes. 2015;9:135–141.
    1. Chien MN, Chen YL, Hung YJ, Wang SY, Lu WT, Chen CH, et al. Glycemic control and adherence to basal insulin therapy in Taiwanese patients with type 2 diabetes mellitus. J Diabetes Investig. 2016 Epub ahead of print.
    1. Huang Y, Gao L, Xie X, Tan SC. Epidemiology of dyslipidemia in Chinese adults: meta-analysis of prevalence, awareness, treatment, and control. Popul Health Metr. 2014;12:28.
    1. Takahashi E, Moriyama K, Yamakado M. Status of dyslipidemia treatment in Japanese adults: an analysis of the 2009 Japan Society of Ningen Dock database. Intern Med. 2013;52:295–301.
    1. Hsuan CF, Lee TL, Chang HL, Tseng WK, Wu CC. A retrospective study of statin use and its effectiveness in Taiwanese. Acta Cardiol Sin. 2009;25:18–25.
    1. Waters DD, Brotons C, Chiang CW, Ferrieres J, Foody J, Jukema JW, et al. Lipid treatment assessment project 2: a multinational survey to evaluate the proportion of patients achieving low-density lipoprotein cholesterol goals. Circulation. 2009;120:28–34.

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