Definition and classification for adverse events following spinal and peripheral joint manipulation and mobilization: A scoping review

Martha Funabashi, Lindsay M Gorrell, Katherine A Pohlman, Andrea Bergna, Nicola R Heneghan, Martha Funabashi, Lindsay M Gorrell, Katherine A Pohlman, Andrea Bergna, Nicola R Heneghan

Abstract

Introduction: Spinal and peripheral joint manipulation and mobilization are interventions used by many healthcare providers to manage musculoskeletal conditions. Although there are many reports of adverse events (or undesirable outcomes) following such interventions, there is no common definition for an adverse event or clarity on any severity classification. This impedes advances of patient safety initiatives and practice. This scoping review mapped the evidence of adverse event definitions and classification systems following spinal and peripheral joint manipulation and mobilization for musculoskeletal conditions in adults.

Methods: An electronic search of the following databases was performed from inception to February 2021: MEDLINE, EMBASE, CINAHL, Scopus, AMED, ICL, PEDro, Cochrane Library, Open Grey and Open Theses and Dissertations. Studies including adults (18 to 65 years old) with a musculoskeletal condition receiving spinal or peripheral joint manipulation or mobilization and providing an adverse event definition and/or classification were included. All study designs of peer-reviewed publications were considered. Data from included studies were charted using a standardized data extraction form and synthesised using narrative analysis.

Results: From 8248 identified studies, 98 were included in the final synthesis. A direct definition for an adverse event and/or classification system was provided in 69 studies, while 29 provided an indirect definition and/or classification system. The most common descriptors to define an adverse event were causality, symptom severity, onset and duration. Twenty-three studies that provided a classification system described only the end anchors (e.g., mild/minor and/or serious) of the classification while 26 described multiple categories (e.g., moderate, severe).

Conclusion: A vast array of terms, definition and classification systems were identified. There is no one common definition or classification for adverse events following spinal and peripheral joint manipulation and mobilization. Findings support the urgent need for consensus on the terms, definition and classification system for adverse events related to these interventions.

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. PRISMA Sc-R flowchart.
Fig 1. PRISMA Sc-R flowchart.

References

    1. James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, et al.. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392: 1789–1858. doi: 10.1016/S0140-6736(18)32279-7
    1. Cieza A, Causey K, Kamenov K, Hanson SW, Chatterji S, Vos T. Global estimates of the need for rehabilitation based on the Global Burden of Disease study 2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet. 2020;6736: 1–12. doi: 10.1016/S0140-6736(20)32340-0
    1. Lin I, Wiles L, Waller R, Goucke R, Nagree Y, Gibberd M, et al.. What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical practice guidelines: Systematic review. Br J Sports Med. 2020;54: 79–86. doi: 10.1136/bjsports-2018-099878
    1. Hawk C, Whalen W, Farabaugh RJ, Daniels CJ, Minkalis AL, Taylor DN, et al.. Best practices for chiropractic management of patients with chronic musculoskeletal pain: A clinical practice guideline. J Altern Complement Med. 2020;26: 884–901. doi: 10.1089/acm.2020.0181
    1. National Institute for Health and Care Excellence. Low back pain and sciatica in over 16s: assessment and management (NG59). Nice. 2016; 1–18.
    1. Rushton Karen; Beeton Ronel; Jordaan John Langendoen; Lenerdene Levesque; Lorrie M and, Jan Pool A. Educational Standards In Orthopaedic Manipulative Therapy. 2016; 91. Available:
    1. Marra AR, Algwizani A, Alzunitan M, Brennan TMH, Edmond MB. Descriptive epidemiology of safety events at an academic medical center. Int J Environ Res Public Health. 2020;17: 1–11. doi: 10.3390/ijerph17010353
    1. Powell FC, Hanigan WC, Olivero WC. A risk/benefit analysis of spinal manipulation therapy for relief of lumbar or cervical pain. Neurosurgery. 1993;33: 73–79. Available: doi: 10.1227/00006123-199307000-00011
    1. Rubinstein SM, Leboeuf-Yde C, Knol DL, de Koekkoek TE, Pfeifle CE, van Tulder MW. The benefits outweigh the risks for patients undergoing chiropractic care for neck pain: a prospective, multicenter, cohort study. J Manipulative Physiol Ther. 2007;30: 408–418. doi: 10.1016/j.jmpt.2007.04.013 Available:
    1. Degenhardt BF, Johnson JC, Brooks WJ, Norman L. Characterizing Adverse Events Reported Immediately After Osteopathic Manipulative Treatment. J Am Osteopath Assoc. 2018;118: 141–149. doi: 10.7556/jaoa.2018.033
    1. Swait G, Finch R. What are the risks of manual treatment of the spine? A scoping review for clinicians. Chiropr Man Ther. 2017;25: 1–15. doi: 10.1186/s12998-017-0168-5
    1. Kohn L, Corrigan J, Donaldson M. To err is human: Building a safer health system. Washington DC: National Academy Press; 2000.
    1. WHO. Towards eliminating avoidable harm in health care—Draft Global Patient Safety Action Plan 2021–2030. World Helath Organ Patient Saf. 2021. Available:
    1. Foundation NPS. Free from Harm: Accelerating Patient Safety Improvement Fifteen Years after To Err Is Human. Boston, MA. 2015. doi: 10.5860/choice.43sup-0367
    1. Statistics NC for H. FastStats A to Z. In: [Internet]. 2015. [cited 26 May 2018]. doi: 10.5860/choice.36sup-305
    1. Carlesso LC, Macdermid JC, Santaguida LP. Standardization of adverse event terminology and reporting in orthopaedic physical therapy: application to the cervical spine. J Orthop Sports Phys Ther. 2010;40: 455–463. doi: 10.2519/jospt.2010.3229
    1. Gorrell LM, Engel RM, Brown B, Lystad RP. The reporting of adverse events following spinal manipulation in randomized clinical trials-a systematic review. Spine J. 2016;16: 1143–1151. doi: 10.1016/j.spinee.2016.05.018
    1. He Y, Sarntivijai S, Lin Y, Xiang Z, Guo A, Zhang S, et al.. OAE: The Ontology of Adverse Events. J Biomed Semantics. 2014;5: 1–13. doi: 10.1186/2041-1480-5-29
    1. Paanalahti K, Holm LW, Nordin M, Asker M, Lyander J, Skillgate E. Adverse events after manual therapy among patients seeking care for neck and/or back pain: a randomized controlled trial. BMC Musculoskelet Disord. 2014;15: 77. doi: 10.1186/1471-2474-15-77
    1. Dougherty PE, Karuza J, Savino D, Katz P. Evaluation of a modified clinical prediction rule for use with spinal manipulative therapy in patients with chronic low back pain: a randomized clinical trial. Chiropr Man Therap. 2014;22: 41. doi: 10.1186/s12998-014-0041-8
    1. Nielsen SM, Tarp S, Christensen R, Bliddal H, Klokker L, Henriksen M. The risk associated with spinal manipulation: an overview of reviews. Syst Rev. 2017;6: 64. doi: 10.1186/s13643-017-0458-y
    1. Pohlman KA, Beirne MO, Thiel H, Cassidy JD, Mior S, Hurwitz EL, et al.. Development and validation of providers’ and patients’ measurement instruments to evaluate adverse events after spinal manipulation therapy. Eur J Integr Med. 2014;6: 451–466. doi: 10.1016/j.eujim.2014.01.002
    1. Carnes D, Mullinger B, Underwood M. Defining adverse events in manual therapies: A modified delphi consensus study. Int J Osteopath Med. 2010;13: 94–98. doi: 10.1016/j.math.2009.02.003
    1. Carlesso LC, Macdermid JC, Santaguida PL, Thabane L. Determining adverse events in patients with neck pain receiving orthopaedic manual physiotherapy: a pilot and feasibility study. Physiother Can. 2013;65: 255–265. doi: 10.3138/ptc.2012-28
    1. Carlesso LC, Macdermid JC, Santaguida PL, Thabane L. A survey of patient’s perceptions of what is “adverse” in manual physiotherapy and predicting who is likely to say so. J Clin Epidemiol. 2013;66: 1184–1191. doi: 10.1016/j.jclinepi.2013.05.005
    1. Tricco AC, Lillie E, Zarin W, O’Brien KK, Colquhoun H, Levac D, et al.. PRISMA Extension for Scoping Reviews (PRISMA-ScR): Checklist and Explanation. Ann Intern Med. 2018;169: 467–473. doi: 10.7326/M18-0850
    1. Munn Z, Peters MDJ, Stern C, Tufanaru C, McArthur A, Aromataris E. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018;18: 1–7. doi: 10.1186/s12874-018-0611-x
    1. Arksey H, O’Malley L. Scoping studies: Towards a methodological framework. Int J Soc Res Methodol Theory Pract. 2005;8: 19–32. doi: 10.1080/1364557032000119616
    1. Levac D, Colquhoun H, O’Brien KK. Scoping studies: advancing the methodology. Implement Sci. 2010;5: 69. doi: 10.1186/1748-5908-5-69
    1. Funabashi M, Pohlman KA, Gorrell LM, Salsbury SA, Bergna A, Heneghan NR. Expert consensus on a standardised definition and severity classification for adverse events associated with spinal and peripheral joint manipulation and mobilisation: Protocol for an international e-Delphi study. BMJ Open. 2021;11: 1–8. doi: 10.1136/bmjopen-2021-050219
    1. Rajendran D, Mullinger B, Fossum C, Collins P, Froud R. Monitoring self-reported adverse events: a prospective, pilot study in a UK osteopathic teaching clinic. Int J Osteopath Med. 2009;12: 49–55. doi: 10.1016/j.ijosm.2008.08.031
    1. de Oliveira RF, Liebano RE, Costa L da CM, Rissato LL, Costa LOP. Immediate effects of region-specific and non-region-specific spinal manipulative therapy in patients with chronic low back pain: a randomized controlled trial. Phys Ther. 2013;93: 748–56. doi: 10.2522/ptj.20120256
    1. Kranenburg HA, Lakke SE, Schmitt MA, Van der Schans CP. Adverse events following cervical manipulative therapy: consensus on classification among Dutch medical specialists, manual therapists, and patients. J Man Manip Ther. 2017;25: 279–287. doi: 10.1080/10669817.2017.1332556
    1. Heneghan NR, Puentedura EJ, Arranz I, Rushton A. Thoracic thrust joint manipulation: An international survey of current practice and knowledge in IFOMPT member countries. Musculoskelet Sci Pract. 2020;50: 102251. doi: 10.1016/j.msksp.2020.102251
    1. O’Shaughnessy J, Drolet M, Roy J-FF, Descarreaux M, O J., D M., et al.. Chiropractic management of patients post-disc arthroplasty: Eight case reports. Chiropr Osteopat. 2010;18: 7. doi: 10.1186/1746-1340-18-7
    1. Senstad O, Leboeuf-Yde C, Borchgrevink C. Predictors of side effects to spinal manipulative therapy. J Manipulative Physiol Ther. 1996. a;19: 441–445. Available:
    1. Leboeuf-Yde C, Hennius B, Rudberg E, Leufvenmark P, Thunman M. Side effects of chiropractic treatment: a prospective study. J Manipulative Physiol Ther. 1997;20: 511–515. Available:
    1. Thiel H, Bolton J. The reporting of patient safety incidents—first experiences with the Chiropractic Reporting and Learning System (CRLS): a pilot study. Clin Chiropr. 2006;9: 139–149. doi: 10.1016/j.clch.2006.04.002
    1. Rubinstein SM, Knol DL, Leboeuf-Yde C, van Tulder MW. Benign adverse events following chiropractic care for neck pain are associated with worse short-term outcomes but not worse outcomes at three months. Spine (Phila Pa 1976). 2008;33: E950–6. 10.1097/BRS.0b013e3181891737
    1. Rubinstein SM, Leboeuf-Yde C, Knol DL, de Koekkoek TE, Pfeifle CE, van Tulder MW, et al.. Predictors of adverse events following chiropractic care for patients with neck pain. J Manipulative Physiol Ther. 2008;31: 94–103. doi: 10.1016/j.jmpt.2007.12.006
    1. Wangler M, Fujikawa R, Hestbæk L, Michielsen T, Raven TJ, Thiel HW, et al.. Creating European guidelines for Chiropractic Incident Reporting and Learning Systems (CIRLS): relevance and structure. Chiropr Man Therap. 2011;19: 1–10. doi: 10.1186/2045-709X-19-9
    1. Eriksen K, Rochester RP, Hurwitz EL. Symptomatic reactions, clinical outcomes and patient satisfaction associated with upper cervical chiropractic care: a prospective, multicenter, cohort study. BMC Musculoskelet Disord. 2011;12: 219. doi: 10.1186/1471-2474-12-219
    1. Puentedura EJ, Landers MR, Cleland JA, Mintken PE, Huijbregts P, Fernandez-DE-LAS-PEñAS C, et al.. Thoracic spine thrust manipulation versus cervical spine thrust manipulation in patients with acute neck pain:A randomized clinical trial. J Orthop Sports Phys Ther. 2011;41: 208–220. doi: 10.2519/jospt.2011.3640
    1. Rubinstein SM, van Middelkoop M, Assendelft WJJJ, de Boer MR, van Tulder MW, SM R, et al.. Spinal manipulative therapy for chronic low-back pain. Cochrane Database Syst Rev. 2011;36: CD008112. 10.1002/14651858.CD008112.pub2
    1. Dagenais S, Brady O, Haldeman S. Shared decision making through informed consent in chiropractic management of low back pain. J Manipulative Physiol Ther. 2012;35: 216–226. doi: 10.1016/j.jmpt.2012.01.004
    1. Nee RJ, Vicenzino B, Jull GA, Cleland JA, Coppieters MW. Neural tissue management provides immediate clinically relevant benefits without harmful effects for patients with nerve-related neck and arm pain: a randomised trial. J Physiother. 2012;58: 23–31. doi: 10.1016/S1836-9553(12)70069-3
    1. Walker BF, Hebert JJ, Stomski NJ, Clarke BR, Bowden RS, Losco B, et al.. Outcomes of Usual Chiropractic. The OUCH Randomized Controlled Trial of Adverse Events. Spine (Phila Pa 1976). 2013;38: 1723–1729. doi: 10.1097/BRS.0b013e31829fefe4
    1. Han L, Zhao P, Guo W, Wei J, Wang F, Fan Y, et al.. Short-term study on risk-benefit outcomes of two spinal manipulative therapies in the treatment of acute radiculopathy caused by lumbar disc herniation: study protocol for a randomized controlled trial. Trials. 2015;16: 122. doi: 10.1186/s13063-015-0634-0
    1. Woodfield HC III, York C, Rochester RP, Bales S, Beebe M, Salminen B, et al.. Craniocervical chiropractic procedures—a précis of upper cervical chiropractic. J Can Chiropr Assoc. 2015;59: 173–192. Available:
    1. Kim K, Shin K, Lee J-H, Seo B, Jung S, Youn Y, et al.. Nonsurgical Korean Integrative Treatments for Symptomatic Lumbar Spinal Stenosis: A Three-Armed Randomized Controlled Pilot Trial Protocol. Evidence-based Complement Altern Med. 2016;2016: 2913248. doi: 10.1155/2016/2913248
    1. Thoomes-de Graaf M, Thoomes EJ, Carlesso L, Kerry R, Rushton A. Adverse effects as a consequence of being the subject of orthopaedic manual therapy training, a worldwide retrospective survey. Musculoskelet Sci Pract. 2017;29: 20–27. doi: 10.1016/j.msksp.2017.02.009
    1. Shin B-C, Kim M-R, Cho J-H, Jung J-Y, Kim K-W, Lee J-H, et al.. Comparative effectiveness and cost-effectiveness of Chuna manual therapy versus conventional usual care for nonacute low back pain: study protocol for a pilot multicenter, pragmatic randomized controlled trial (pCRN study). Trials. 2017;18: 26. doi: 10.1186/s13063-016-1756-8
    1. Do HJ, Shin J-S, Lee J, Lee YJ, Kim M-R, Cho J-H, et al.. Comparative effectiveness and economic evaluation of Chuna manual therapy for chronic neck pain: protocol for a multicenter randomized controlled trial 11 Medical and Health Sciences 1103 Clinical Sciences 11 Medical and Health Sciences 1117 Public Health. Trials. 2018;19: 663. Available: doi: 10.1186/s13063-018-3016-6
    1. Tabell V, Tarkka IM, Holm LW, Skillgate E. Do adverse events after manual therapy for back and/or neck pain have an impact on the chance to recover? A cohort study. Chiropr Man Therap. 2019;27: 27. doi: 10.1186/s12998-019-0248-9
    1. Lim K-T, Hwang E-H, Cho J-H, Jung J-Y, Kim K-W, Ha I-H, et al.. Comparative effectiveness of Chuna manual therapy versus conventional usual care for non-acute low back pain: a pilot randomized controlled trial. Trials. 2019;20: 216. doi: 10.1186/s13063-019-3302-y
    1. Pohlman KA, Funabashi M, Ndetan H, Hogg-Johnson S, Bodnar P, Kawchuk G, et al.. Assessing Adverse Events After Chiropractic Care at a Chiropractic Teaching Clinic: An Active-Surveillance Pilot Study. J Manipulative Physiol Ther. 2020;43: 845–854. doi: 10.1016/j.jmpt.2020.05.007
    1. Senstad O, Leboeuf-Yde C, Borchgrevink C. Frequency and characteristics of side effects of spinal manipulative therapy. Spine (Phila Pa 1976). 1997;22: 435–441. doi: 10.1097/00007632-199702150-00017
    1. Malone DG, Baldwin NG, Tomecek FJ, Boxell CM, Gaede SE, Covington CG, et al.. Complications of cervical spine manipulation therapy: 5-year retrospective study in a single-group practice. Neurosurg Focus. 2002;13: ecp1. doi: 10.3171/foc.2002.13.6.8
    1. Hurwitz EL, Morgenstern H, Vassilaki M, Chiang L-M. Frequency and clinical predictors of adverse reactions to chiropractic care in the UCLA neck pain study. Spine (Phila Pa 1976). 2005;30: 1477–1484. Available: doi: 10.1097/01.brs.0000167821.39373.c1
    1. Kuczynski JJ, Schwieterman B, Columber K, Knupp D, Shaub L, Cook CE. Effectiveness of physical therapist administered spinal manipulation for the treatment of low back pain: a systematic review of the literature. Int J Sports Phys Ther. 2012;7: 647–662. Available:
    1. Puentedura EJ, March J, Anders J, Perez A, Landers MR, Wallmann HW, et al.. Safety of cervical spine manipulation: are adverse events preventable and are manipulations being performed appropriately? A review of 134 case reports. J Man Manip Ther. 2012;20: 66–74. doi: 10.1179/2042618611Y.0000000022
    1. Björklund M, Djupsjöbacka M, Svedmark Å, Häger C. Effects of tailored neck-shoulder pain treatment based on a decision model guided by clinical assessments and standardized functional tests. A study protocol of a randomized controlled trial. BMC Musculoskelet Disord. 2012;13. doi: 10.1186/1471-2474-13-75
    1. Reid SA, Rivett DA, Katekar MG, Callister R. Comparison of mulligan sustained natural apophyseal glides and maitland mobilizations for treatment of cervicogenic dizziness: a randomized controlled trial. Phys Ther. 2014;94: 466–476. doi: 10.2522/ptj.20120483
    1. MacPherson H, Newbronner E, Chamberlain R, Hopton A. Patients’ experiences and expectations of chiropractic care: a national crosssectional survey. Chiropr Man Therap. 2015;23: 3. doi: 10.1186/s12998-014-0049-0
    1. Rajendran D, Bright P, Mullinger B, Froud R. Reporting patterns and predictors of common minor adverse events following osteopathic treatment: Lessons learned from a prospective, patient-administered questionnaire feasibility study in a UK teaching clinic. Eur J Integr Med. 2015;7: 634–644. 10.1016/j.eujim.2015.09.005
    1. Puentedura EJ, O’Grady WH. Safety of thrust joint manipulation in the thoracic spine: a systematic review. J Man Manip Ther. 2015;23: 154–161. Available: doi: 10.1179/2042618615Y.0000000012
    1. Petrozzi MJ, Leaver A, Jones MK, Ferreira PH, Rubinstein SM, Mackey MG. Does an online psychological intervention improve self-efficacy and disability in people also receiving Multimodal Manual Therapy for chronic low back pain compared to Multimodal Manual Therapy alone? Design of a randomized controlled trial. Chiropr Man Ther. 2015;23: 1–8. doi: 10.1186/s12998-015-0080-9
    1. Bussières AE, Stewart G, Al-Zoubi F, Decina P, Descarreaux M, Hayden J, et al.. The Treatment of Neck Pain–Associated Disorders and Whiplash-Associated Disorders: A Clinical Practice Guideline. J Manip Physiol Ther. 2016;39: 523–564.e27. doi: 10.1016/j.jmpt.2016.08.007
    1. Kranenburg HA, Schmitt MA, Puentedura EJ, Luijckx GJ, van der Schans CP. Adverse events associated with the use of cervical spine manipulation or mobilization and patient characteristics: A systematic review. Musculoskelet Sci Pract. 2017;28: 32–38. doi: 10.1016/j.msksp.2017.01.008
    1. Heneghan NR, Davies SE, Puentedura EJ, Rushton A. Knowledge and pre-thoracic spinal thrust manipulation examination: a survey of current practice in the UK. J Man Manip Ther. 2018;26: 301–309. doi: 10.1080/10669817.2018.1507269
    1. Coulter ID, Crawford C, Hurwitz EL, Vernon H, Khorsan R, Suttorp Booth M, et al.. Manipulation and mobilization for treating chronic low back pain: a systematic review and meta-analysis. Spine J. 2018;18: 866–879. doi: 10.1016/j.spinee.2018.01.013
    1. Mikhail J, Funabashi M, Descarreaux M, Pagé I. Assessing forces during spinal manipulation and mobilization: factors influencing the difference between forces at the patient-table and clinician-patient interfaces. Chiropr Man Therap. 2020;28: 57. doi: 10.1186/s12998-020-00346-1
    1. Stern PJ, Cote P, Cassidy JD. A series of consecutive cases of low back pain with radiating leg pain treated by chiropractors. J Manipulative Physiol Ther. 1995;18: 335–342. Available:
    1. Hendry L, Yardley K, Hurley L, AR G. Agreement of physiotherapists with advanced training in manual therapy on magnitude of adverse events following the application of cervical spine manual therapy. Physiother Canada. 2002;54: 199–205. Available:
    1. Team UBT. United Kingdom back pain exercise and manipulation (UK BEAM) randomised trial: Effectiveness of physical treatments for back pain in primary care. BMJ. 2004;329: 1377. doi: 10.1136/
    1. Gibbons P, Tehan P. HVLA thrust techniques: what are the risks? Int J Osteopath Med. 2006;9: 4–12. 10.1016/j.ijosm.2006.02.005
    1. Thiel HW, Bolton JE, Docherty S, Portlock JC, HW T, JE B, et al.. Safety of chiropractic manipulation of the cervical spine: a prospective national survey. Spine (Phila Pa 1976). 2007;32: 2375–2379. doi: 10.1097/BRS.0b013e3181557bb1
    1. Haneline MT, Cooperstein R, MT H, Cooperstein R, Haneline MT, Cooperstein R. Chiropractic care for patients with acute neck pain: results of a pragmatic practice-based feasibility study. J Chiropr Med. 2009;8: 143–155. doi: 10.1016/j.jcm.2009.08.003
    1. Carlesso LC, Cairney J, Dolovich L, Hoogenes J. Defining adverse events in manual therapy: An exploratory qualitative analysis of the patient perspective. Man Ther. 2011;16: 440–446. doi: 10.1016/j.math.2011.02.001
    1. Hebert JJ, Stomski NJ, French SD, Rubinstein SM. Serious Adverse Events and Spinal Manipulative Therapy of the Low Back Region: A Systematic Review of Cases. J Manipulative Physiol Ther. 2015;38: 677–691. doi: 10.1016/j.jmpt.2013.05.009
    1. Keating L. A Randomised Controlled Trial of Multimodal Physiotherapy for Patients With Acute / Sub-acute Cervical Radiculopathy. In: Clinical [Internet]. 2015. [cited 16 Sep 2021]. Available:
    1. Kressig M, Peterson CK, McChurch K, Schmid C, Leemann S, Anklin B, et al.. Relationship of Modic Changes, Disk Herniation Morphology, and Axial Location to Outcomes in Symptomatic Cervical Disk Herniation Patients Treated With High-Velocity, Low-Amplitude Spinal Manipulation: A Prospective Study. J Manipulative Physiol Ther. 2016;39: 565–575. doi: 10.1016/j.jmpt.2016.08.004
    1. Lisi AJ, Salsbury SA, Hawk C, Vining RD, Wallace RB, Branson R, et al.. Chiropractic Integrated Care Pathway for Low Back Pain in Veterans: Results of a Delphi Consensus Process. J Manipulative Physiol Ther. 2018;41: 137–148. doi: 10.1016/j.jmpt.2017.10.001
    1. Frydman A, Johnston R V, Smidt N, Green S, Buchbinder R. Manual therapy and exercise for lateral elbow pain. Cochrane Database Syst Rev. 2018. doi: 10.1002/14651858.CD013042
    1. Smith D, Hoogenboom B. Sideline Management of Acute Dislocation of the Glenohumeral Joint—A Unique Approach to Athlete Self-Reduction. Int J Sports Phys Ther. 2013;8: 80–83. Available:
    1. Yao M, Tang ZY, Cui XJ, Sun YL, Ye XL, Wang P, et al.. Shi-Style Cervical Mobilizations Versus Massage for Cervical Vertigo: A Multicenter, Randomized, Controlled Clinical Trial. J Altern Complement Med. 2020;26: 58–66. doi: 10.1089/acm.2019.0113
    1. Gross AR, Kay TM, Kennedy C, Gasner D, Hurley L, Yardley K, et al.. Clinical practice guideline on the use of manipulation or mobilization in the treatment of adults with mechanical neck disorders. Man Ther. 2002;7: 193–205. doi: 10.1054/math.2002.0477
    1. Skelly AC, Chou R, Dettori JR, Turner JA, Friedly JL, Rundell SD, et al.. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review Update. Agency Healthc Res Qual. 2020; 20–90.
    1. Funabashi M, French SD, Kranenburg HAR, Hebert JJ. Serious adverse events following lumbar spine mobilization or manipulation and potential associated factors: a systematic review protocol. JBI Evid Synth. 2020;Publish Ah. doi: 10.11124/JBIES-20-00129
    1. Spilker B. Guide to Clinical Trials. Philadelphia: Lippincott Williams & Wilkins; 1991.
    1. Senstad O, Leboeuf-Yde C, Borchgrevink CF. Side-effects of chiropractic spinal manipulation: Types frequency, discomfort and course. Scand J Prim Health Care. 1996. b;14: 50–53. doi: 10.3109/02813439608997068
    1. Carnes D, Mars TS, Mullinger B, Froud R, Underwood M. Adverse events and manual therapy: a systematic review. Man Ther. 2010;15: 355–363. doi: 10.1016/j.math.2009.12.006
    1. Cagnie B, Vinck E, Beernaert A, Cambier D. How common are side effects of spinal manipulation and can these side effects be predicted?. Man Ther. 2004;9: 151–156. doi: 10.1016/j.math.2004.03.001
    1. Hay EM, Mullis R, Lewis M, Vohora K, Main CJ, Watson P, et al.. Comparison of physical treatments versus a brief pain-management programme for back pain in primary care: A randomised clinical trial in physiotherapy practice. Lancet. 2005;365: 2024–2030. doi: 10.1016/S0140-6736(05)66696-2
    1. Bronfort G, Hondras MA, Schulz CA, Evans RL, Long CR, Grimm R. Spinal manipulation and home exercise with advice for subacute and chronic back-related leg pain: A trial with adaptive allocation. Ann Intern Med. 2014;161: 381–391. doi: 10.7326/M14-0006
    1. Bronfort G, Haas M, Evans R, Kawchuk G, Dagenais S. Evidence-informed management of chronic low back pain with spinal manipulation and mobilization. Spine J. 2008;8: 213–225. doi: 10.1016/j.spinee.2007.10.023
    1. Cleland JA, Glynn P, Whitman JM, Eberhart SL, MacDonald C, Childs JD. Short-term effects of thrust versus nonthrust mobilization/manipulation directed at the thoracic spine in patients with neck pain: a randomized clinical trial. Phys Ther. 2007;87: 431–440. doi: 10.2522/ptj.20060217 Available:
    1. Giles LGF, Muller R, Winter GJ. Patient satisfaction, characteristics, radiology, and complications associated with attending a specialized government-funded multidisciplinary spinal pain unit. J Manipulative Physiol Ther. 2003;26: 293–299. doi: 10.1016/S0161-4754(03)00045-9
    1. Satpute K, Bedekar N, Hall T. Headache symptom modification: the relevance of appropriate manual therapy assessment and management of a patient with features of migraine and cervicogenic headache–a case report. J Man Manip Ther. 2020;28: 181–188. doi: 10.1080/10669817.2019.1662637
    1. Barrett AJ, Breen AC. Adverse effects of spinal manipulation. J R Soc Med. 2000;93: 258–259. Available: doi: 10.1177/014107680009300511
    1. Meeker WC, Mootz RD, Haldeman S. The state of chiropractic research. Top Clin Chiropr. 2002;9: 1–13.
    1. Canadian Chiropractic Association, Canadian Federation of Chiropractic Regulatory Boards, Clinical Practice Guidelines Development Initiative, Guidelines Development Committee (GDC), Anderson-Peacock E, Blouin J-S, et al.. Chiropractic clinical practice guideline: evidence-based treatment of adult neck pain not due to whiplash. J Can Chiropr Assoc. 2005;49: 158–209. Available:
    1. Dagenais S, Gay RE, Tricco AC, Freeman MD, Mayer JM. NASS Contemporary Concepts in Spine Care: spinal manipulation therapy for acute low back pain. Spine J. 2010;10: 918–40. doi: 10.1016/j.spinee.2010.07.389
    1. Carlesso LC, Gross AR, Santaguida PL, Burnie S, Voth S, Sadi J. Adverse events associated with the use of cervical manipulation and mobilization for the treatment of neck pain in adults: A systematic review. Man Ther. 2010;15: 434–444. doi: 10.1016/j.math.2010.02.006
    1. Yin P, Gao N, Wu J, Litscher G, Xu S. Adverse Events of Massage Therapy in Pain-Related Conditions: A Systematic Review. Evidence-Based Complement Altern Med. 2014;2014: 1–11. doi: 10.1155/2014/480956
    1. Coulter ID, Crawford C, Vernon H, Hurwitz EL, Khorsan R, Booth MS, et al.. Manipulation and Mobilization for Treating Chronic Nonspecific Neck Pain: A Systematic Review and Meta-Analysis for an Appropriateness Panel. Pain Physician. 2019;22: E55–E70. Available:
    1. Funabashi M, Pohlman KA, Goldsworthy R, Lee A, Tibbles A, Mior S, et al.. Beliefs, perceptions and practices of chiropractors and patients about mitigation strategies for benign adverse events after spinal manipulation therapy. Chiropr Man Therap. 2020;28: 46. doi: 10.1186/s12998-020-00336-3
    1. Zhang M, Du G, Liu C, Li W, Yang J, Chen B, et al.. Efficacy and safety of Shi-style cervical manipulation therapy for treating acute and subacute neck pain: study protocol for a randomized controlled trial. Trials. 2021;22: 123. doi: 10.1186/s13063-021-05062-6
    1. Ernst E. Prospective investigations into the safety of spinal manipulation. J Pain Symptom Manage. 2001;21: 238–242. Available: doi: 10.1016/s0885-3924(00)00262-1
    1. Murphy DR, Hurwitz EL, Gregory AA. Manipulation in the Presence of Cervical Spinal Cord Compression: a Case Series. J Manipulative Physiol Ther. 2006;29: 236–244. doi: 10.1016/j.jmpt.2006.01.001
    1. Brantingham JW, Globe GA, Jensen ML, Cassa TK, Globe DR, Price JL, et al.. A feasibility study comparing two chiropractic protocols in the treatment of patellofemoral pain syndrome. J Manipulative Physiol Ther. 2009;32: 536–548. doi: 10.1016/j.jmpt.2009.08.005
    1. JM L, Forrest L. Withdrawal rates as a consequence of disclosure of risk associated with manipulation of the cervical spine: A survey. <h5>Chiropractic & Osteopathy</h5>. 2010. p. Online access only 24 p.
    1. Bronfort G, Evans R, Anderson A V, Svendsen KH, Bracha Y, Grimm RH. Spinal manipulation, medication, or home exercise with advice for acute and subacute neck pain: a randomized trial. Ann Intern Med. 2012;156: 1–10. doi: 10.7326/0003-4819-156-1-201201030-00002
    1. Rajendran D, Bright P, Bettles S, Carnes D, Mullinger B. What puts the adverse in ‘adverse events’? Patients’ perceptions of post-treatment experiences in osteopathy–A qualitative study using focus groups. Man Ther. 2012;17: 305–311. doi: 10.1016/j.math.2012.02.011
    1. Page MJ, Green S, Kramer S, Johnston R V, McBain B, Chau M, et al.. Manual therapy and exercise for adhesive capsulitis (frozen shoulder). Cochrane database Syst Rev. 2014; CD011275. doi: 10.1002/14651858.CD011275
    1. Bussières AE, Stewart G, Al-Zoubi F, Decina P, Descarreaux M, Haskett D, et al.. Spinal Manipulative Therapy and Other Conservative Treatments for Low Back Pain: A Guideline From the Canadian Chiropractic Guideline Initiative. J Manipulative Physiol Ther. 2018;41: 265–293. doi: 10.1016/j.jmpt.2017.12.004
    1. Morris S, Booth J. Shaping conservative spinal services with the Spine Tango Registry. Eur Spine J. 2018;27: 543–553. doi: 10.1007/s00586-018-5484-5
    1. Peters R, Mutsaers B, Verhagen AP, Koes BW, Pool-Goudzwaard AL. Prospective Cohort Study of Patients With Neck Pain in a Manual Therapy Setting: Design and Baseline Measures. J Manipulative Physiol Ther. 2019;42: 471–479. doi: 10.1016/j.jmpt.2019.07.001
    1. Mabry LM, Notestine JP, Moore JH, Bleakley CM, Taylor JB. Safety Events and Privilege Utilization Rates in Advanced Practice Physical Therapy Compared to Traditional Primary Care: An Observational Study. Mil Med. 2020;185: e290–e297. doi: 10.1093/milmed/usz176
    1. Hurwitz EL. Epidemiology: Spinal manipulation utilization. J Electromyogr Kinesiol. 2012; 1–7. doi: 10.1016/j.jelekin.2012.01.006
    1. Ernst E. Adverse effects of spinal manipulation: a systematic review. J R Soc Med. 2007;100: 330–338. doi: 10.1177/014107680710000716
    1. Hutting N, Kerry R, Coppieters MW, Scholten-Peeters GGM. Considerations to improve the safety of cervical spine manual therapy. Musculoskelet Sci Pract. 2018;33: 41–45. doi: 10.1016/j.msksp.2017.11.003
    1. Loke YK, Golder su P, Vandenbroucke JP. Comprehensive evaluations of the adverse effects of drugs: Importance of appropriate study selection and data sources. Ther Adv Drug Saf. 2011;2: 59–68. doi: 10.1177/2042098611401129
    1. Rasmussen J. Human error and the problem of causality in analysis of accidents. Philos Trans R Soc Lond B Biol Sci. 1990;327. doi: 10.1098/rstb.1990.0088
    1. Healy D. Science, rhetoric and the causality of adverse events. Int J Risk Saf Med. 2011;23: 149–162. doi: 10.3233/JRS-2011-0534
    1. Rodrigues PP, Ferreira-Santos D, Silva A, Polónia J, Ribeiro-Vaz I. Causality assessment of adverse drug reaction reports using an expert-defined Bayesian network. Artif Intell Med. 2018;91: 12–22. doi: 10.1016/j.artmed.2018.07.005
    1. Bellavite P. Causality assessment of adverse events following immunization: The problem of multifactorial pathology. F1000Research. 2020;9. doi: 10.12688/f1000research.22600.1
    1. Shojania K, Duncan B, McDonald K, Wachter R, Al E. Making health care safer: A critical analysis of patient safety practices. Agency Healthc Res Qual. 2001. doi: 10.1016/s1086-5802(16)30206-6
    1. Zorzela L, Mior S, Boon H, Gross A, Yager J, Carter R, et al.. Tool to assess causality of direct and indirect adverse events associated with therapeutic interventions. Curr Med Res Opin. 2018;34: 407–414. doi: 10.1080/03007995.2017.1383891
    1. Doherty MJ. Algorithms for assessing the probability of an Adverse Drug Reaction. Respir Med CME. 2009;2: 63–67. doi: 10.1016/j.rmedc.2009.01.004
    1. Pettker CM. Systematic approaches to adverse events in obstetrics, Part I: Event identification and classification. Semin Perinatol. 2017;41: 151–155. doi: 10.1053/j.semperi.2017.03.003
    1. Liberman JS, Liberman JS, Slagle JM, Slagle JM, Whitney G, Shotwell MS, et al.. Incidence and classification of nonroutine events during anesthesia care. Anesthesiology. 2020; 41–52. doi: 10.1097/ALN.0000000000003336
    1. Kaufman G. Adverse drug reactions: classification, susceptibility and reporting. Nurs Stand. 2016;30: 53–63. doi: 10.7748/ns.2016.e10214
    1. Kaafarani HMA, Mavros MN, Hwabejire J, Fagenholz P, Yeh DD, Demoya M, et al.. Derivation and validation of a novel severity classification for intraoperative adverse events. J Am Coll Surg. 2014;218: 1120–1128. doi: 10.1016/j.jamcollsurg.2013.12.060
    1. Albert M, Friesen F, Rowland P, Laberge S. Problematizing assumptions about interdisciplinary research: implications for health professions education research. Adv Heal Sci Educ. 2020;25: 755–767. doi: 10.1007/s10459-019-09911-7
    1. Larivière V, Gingras Y. Measuring interdisciplinarity. In: Cronin B, Sugimoto C, editors. Beyond bibliometrics: Harnessing multidimensional indicators of scholarly impact. Cambridge, MA: MIT Press; 2014. pp. 187–200.
    1. Rozmovits L, Mior S, Boon H. Exploring approaches to patient safety: the case of spinal manipulation therapy. BMC Complement Altern Med. 2016;16: 164. doi: 10.1186/s12906-016-1149-2
    1. Rushton A, Rivett D, Carlesso L, Flynn T, Hing W, Kerry R. International framework for examination of the cervical region for potential of Cervical Arterial Dysfunction prior to Orthopaedic Manual Therapy intervention. Man Ther. 2014;19: 222–228. doi: 10.1016/j.math.2013.11.005
    1. Stochkendahl MJ, Rezai M, Torres P, Sutton D, Tuchin P, Brown R, et al.. The chiropractic workforce: A global review. Chiropr Man Ther. 2019;27: 1–9. doi: 10.1186/s12998-019-0255-x
    1. Higgs J, Refshauge K, Ellis E. Portrait of the physiotherapy profession. J Interprof Care. 2001;15: 79–89. doi: 10.1080/13561820020022891
    1. Osteopathic International Alliance. Global review of osteopathic medicine and osteopathy 2020. 2020.
    1. Foo JS, Storr M, Maloney S. Registration factors that limit international mobility of people holding physiotherapy qualifications: A systematic review. Health Policy (New York). 2016;120: 665–673. doi: 10.1016/j.healthpol.2016.04.008
    1. Hartnett DA, Milner JD, Kleinhenz DT, Kuris EO, Daniels AH. Malpractice Litigation Involving Chiropractic Spinal Manipulation. World Neurosurg. 2021;149: e108–e115. doi: 10.1016/j.wneu.2021.02.067
    1. Cicconi M, Mangiulli T, Bolino G. Onset of complications following cervical manipulation due to malpractice in osteopathic treatment: a case report. Med Sci Law. 2014;54: 230–233. doi: 10.1177/0025802413513451
    1. Boucher P, Robidoux S. Lumbar disc herniation and cauda equina syndrome following spinal manipulative therapy: A review of six court decisions in Canada. J Forensic Leg Med. 2014;22: 159–169. doi: 10.1016/j.jflm.2013.12.026
    1. Narayan MC. Culture’s effects on pain assessment and management. Am J Nurs. 2010;110: 38–47; quiz 48–9. doi: 10.1097/01.NAJ.0000370157.33223.6d
    1. Airhihenbuwa CO. Of culture and multiverse: Renouncing “the universal truth” in health. J Heal Educ. 1999;30: 267–273. doi: 10.1080/10556699.1999.10603409
    1. Dutta MJ. Communicating About Culture and Health: Theorizing Culture-Centered and Cultural Sensitivity Approaches. Commun Theory. 2007;17: 304–328. doi: 10.1111/j.1468-2885.2007.00297.x
    1. Iwelunmor J, Newsome V, Airhihenbuwa CO. Framing the impact of culture on health: A systematic review of the PEN-3 cultural model and its application in public health research and interventions. Ethn Heal. 2014;19: 20–46. doi: 10.1080/13557858.2013.857768
    1. Singhal A. Focusing on the forest, not just the tree: cultural strategies for combating AIDS. Inst Strateg Mark Commun. 2003;1: 21–28. Available:

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