Noninvasive Fractional Flow Reserve Derived From Coronary CT Angiography: Clinical Data and Scientific Principles
James K Min, Charles A Taylor, Stephan Achenbach, Bon Kwon Koo, Jonathon Leipsic, Bjarne L Nørgaard, Nico J Pijls, Bernard De Bruyne, James K Min, Charles A Taylor, Stephan Achenbach, Bon Kwon Koo, Jonathon Leipsic, Bjarne L Nørgaard, Nico J Pijls, Bernard De Bruyne
Abstract
Fractional flow reserve derived from coronary computed tomography angiography enables noninvasive assessment of the hemodynamic significance of coronary artery lesions and coupling of the anatomic severity of a coronary stenosis with its physiological effects. Since its initial demonstration of feasibility of use in humans in 2011, a significant body of clinical evidence has developed to evaluate the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve compared with an invasive fractional flow reserve reference standard. The purpose of this paper was to describe the scientific principles and to review the clinical data of this technology recently approved by the U.S. Food and Drug Administration.
Keywords: FFR(CT); coronary CTA; coronary artery disease; fractional flow reserve; ischemia.
Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Source: PubMed