Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk

Carolina Valdiviezo, Vesna D Garovic, Pamela Ouyang, Carolina Valdiviezo, Vesna D Garovic, Pamela Ouyang

Abstract

More women than men die each year of cardiovascular disease, which remains the leading cause of death in the United States. Sex-specific factors, including pregnancy-related disorders, should be considered when assessing cardiovascular (CV) risk in women. Hypertensive disorders of pregnancy have been associated with CV risk later in life and may identify women in whom earlier primary prevention may reduce their risk. This article reviews the physiologic changes in blood pressure during pregnancy, current definitions of hypertensive diseases of pregnancy and preeclampsia, and postulated pathophysiologic mechanisms leading to preeclampsia that might contribute to later CV risk. Also summarized are studies providing evidence on the association between hypertensive diseases of pregnancy and future CV risk.

© 2012 Wiley Periodicals, Inc.

References

    1. Lloyd‐Jones D, Adams RJ, Brown TM, et al. Heart disease and stroke statistics—2010 update: a report from the American Heart Association. Circulation. 2010;121:e46–e215.
    1. Bellamy L, Casas JP, Hingorani AD, et al. Pre‐eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta‐analysis. BMJ. 2007;335:974–977.
    1. McDonald SD, Malinowski A, Zhou Q, et al. Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta‐analyses. Am Heart J. 2008;156:918–930.
    1. MacGillivray I, Rose GA, Rowe B. Blood pressure survey in pregnancy. Clin Sci. 1969;37:395–407.
    1. Wilson M, Morganti AA, Zervoudakis I, et al. Blood pressure, the renin‐aldosterone system and sex steroids throughout normal pregnancy. Am J Med. 1980;68:97–104.
    1. Robson SC, Hunter S, Boys RJ, et al. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol. 1989;256(4 part 2):H1060–H1065.
    1. Gant NF, Worley RJ, Everett RB, et al. Control of vascular responsiveness during human pregnancy. Kidney Int. 1980;18:253–258.
    1. Metcalfe J, Ueland K. Maternal cardiovascular adjustments to pregnancy. Prog Cardiovasc Dis. 1974;16:363–374.
    1. Weiner CP, Thompson LP. Nitric oxide and pregnancy. Semin Perinatol. 1997;21:367–380.
    1. Knock GA, Poston L. Bradykinin‐mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia. Am J Obstet Gynecol. 1996;175:1668–1674.
    1. Report of the National High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy. Am J Obstet Gynecol. 2000;183:S1–S22.
    1. ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia: number 33, January 2002. Obstet Gynecol. 2002;99:159–167.
    1. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102:181–192.
    1. Carty DM, Delles C, Dominiczak AF. Preeclampsia and future maternal health. J Hypertens. 2010;28:1349–1355.
    1. Carr DB, Newton KM, Utzschneider KM, et al. Preeclampsia and risk of developing subsequent diabetes. Hypertens Pregnancy. 2009;28:435–447.
    1. Callaway LK, Lawlor DA, O'Callaghan M, et al. Diabetes mellitus in the 21 years after a pregnancy that was complicated by hypertension: findings from a prospective cohort study. Am J Obstet Gynecol. 2007;197:492.e1–492.e7.
    1. Libby G, Murphy DJ, McEwan NF, et al. Pre‐eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study from the Walker cohort. Diabetologia. 2007;50:523–530.
    1. Girouard J, Giguère Y, Moutquin JM, et al. Previous hypertensive disease of pregnancy is associated with alterations of markers of insulin resistance. Hypertension. 2007;49:1056–1062.
    1. Potter JM, Nestel PJ. The hyperlipidemia of pregnancy in normal and complicated pregnancies. Am J Obstet Gynecol. 1979;133:165–170.
    1. Al MD, van Houwelingen AC, Kester AD, et al. Maternal essential fatty acid patterns during normal pregnancy and their relationship to the neonatal essential fatty acid status. Br J Nutr. 1995;74:55–68.
    1. Branch DW, Mitchell MD, Miller E, et al. Pre‐eclampsia and serum antibodies to oxidised low‐density lipoprotein. Lancet. 1994;343:645–646.
    1. Hubel CA, McLaughlin MK, Evans RW, et al. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol. 1996;174:975–982.
    1. Ogura K, Miyatake T, Fukui O, et al. Low‐density lipoprotein particle diameter in normal pregnancy and preeclampsia. J Atheroscler Thromb. 2002;9:42–47.
    1. Maynard SE, Moore Simas TA, Solitro MJ, et al. Circulating angiogenic factors in singleton vs multiple‐gestation pregnancies. Am J Obstet Gynecol. 2008;198:200.e1–200.e7.
    1. Sheppard SJ, Khalil RA. Risk factors and mediators of the vascular dysfunction associated with hypertension in pregnancy. Cardiovasc Hematol Disord Drug Targets. 2010;10:33–52.
    1. Venkatesha S, Toporsian M, Lam C, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia [published correction appears in Nat Med. 2006;12:862]. Nat Med. 2006;12:642–649.
    1. Levine RJ, Maynard SE, Qian C, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672–683.
    1. Agatisa PK, Ness RB, Roberts JM, et al. Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk. Am J Physiol Heart Circ Physiol. 2004;286:H1389–H1393.
    1. Lampinen KH, Rönnback M, Kaaja RJ, et al. Impaired vascular dilatation in women with a history of pre‐eclampsia. J Hypertens. 2006;24:751–756.
    1. Ramsay JE, Stewart F, Greer IA, et al. Microvascular dysfunction: a link between pre‐eclampsia and maternal coronary heart disease. BJOG. 2003;110:1029–1031.
    1. Fisher KA, Luger A, Spargo BH, et al. Hypertension in pregnancy: clinical‐pathological correlations and remote prognosis. Medicine (Baltimore). 1981;60:267–276.
    1. Lafayette RA, Druzin M, Sibley R, et al. Nature of glomerular dysfunction in pre‐eclampsia. Kidney Int. 1998;54:1240–1249.
    1. Garovic VD, Wagner SJ, Petrovic LM, et al. Glomerular expression of nephrin and synaptopodin, but not podocin, is decreased in kidney sections from women with preeclampsia. Nephrol Dial Transplant. 2007;22:1136–1143.
    1. Adams EM, Macgillivray I. Long‐term effect of preeclampsia on blood‐pressure. Lancet. 1961;2:1373–1375.
    1. Carleton H, Forsythe A, Flores R. Remote prognosis of preeclampsia in women 25 years old and younger. Am J Obstet Gynecol. 1988;159:156–160.
    1. Laivuori H, Tikkanen MJ, Ylikorkala O. Hyperinsulinemia 17 years after preeclamptic first pregnancy. J Clin Endocrinol Metab. 1996;81:2908–2911.
    1. Marin R, Gorostidi M, Portal CG, et al. Long‐term prognosis of hypertension in pregnancy. Hypertens Pregnancy. 2000;19:199–209.
    1. North RA, Simmons D, Barnfather D, et al. What happens to women with preeclampsia? Microalbuminuria and hypertension following preeclampsia. Aust N Z J Obstet Gynaecol. 1996;36:233–238.
    1. Sattar N, Ramsay J, Crawford L, et al. Classic and novel risk factor parameters in women with a history of preeclampsia. Hypertension. 2003;42:39–42.
    1. Sibai BM, el‐Nazer A, Gonzalez‐Ruiz A. Severe preeclampsia‐eclampsia in young primigravid women: subsequent pregnancy outcome and remote prognosis. Am J Obstet Gynecol. 1986;155:1011–1016.
    1. Croft P, Hannaford PC. Risk factors for acute myocardial infarction in women: evidence from the Royal College of General Practitioners' oral contraception study. BMJ. 1989;298:165–168.
    1. Funai EF, Friedlander Y, Paltiel O, et al. Long‐term mortality after preeclampsia. Epidemiology. 2005;16:206–215.
    1. Hannaford P, Ferry S, Hirsch S. Cardiovascular sequelae of toxaemia of pregnancy. Heart. 1997;77:154–158.
    1. Haukkamaa L, Salminen M, Laivuori H, et al. Risk for subsequent coronary artery disease after preeclampsia. Am J Cardiol. 2004;93:805–808.
    1. Irgens HU, Reisaeter L, Irgens LM, et al. Long term mortality of mothers and fathers after pre‐eclampsia: population based cohort study. BMJ. 2001;323:1213–1217.
    1. Jonsdottir LS, Arngrimsson R, Geirsson RT, et al. Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstet Gynecol Scand. 1995;74:772–776.
    1. Kaaja R, Kinnunen T, Luoto R. Regional differences in the prevalence of pre‐eclampsia in relation to the risk factors for coronary artery disease in women in Finland. Eur Heart J. 2005;26:44–50.
    1. Kestenbaum B, Seliger SL, Easterling TR, et al. Cardiovascular and thromboembolic events following hypertensive pregnancy. Am J Kidney Dis. 2003;42:982–989.
    1. Mann JI, Doll R, Thorogood M, et al. Risk factors for myocardial infarction in young women. Br J Prev Soc Med. 1976;30:94–100.
    1. Ray JG, Vermeulen MJ, Schull MJ, et al. Cardiovascular Health After Maternal Placental Syndromes (CHAMPS): population‐based retrospective cohort study. Lancet. 2005;366:1797–1803.
    1. Rosenberg L, Miller DR, Kaufman DW, et al. Myocardial infarction in women under 50 years of age. JAMA. 1983;250:2801–2806.
    1. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129 290 births. Lancet. 2001;357:2002–2006.
    1. Wikström AK, Haglund B, Olovsson M, et al. The risk of maternal ischaemic heart disease after gestational hypertensive disease. BJOG. 2005;112:1486–1491.
    1. Wilson BJ, Watson MS, Prescott GJ, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326:845–849.
    1. Lykke JA, Langhoff‐Roos J, Sibai BM, et al. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009;53:944–951.
    1. Magnussen EB, Vatten LJ, Smith GD, et al. Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. Obstet Gynecol. 2009;114:961–970.
    1. Garovic VD, Bailey KR, Boerwinkle E, et al. Hypertension in pregnancy as a risk factor for cardiovascular disease later in life. J Hypertens. 2010;28:826–833.
    1. Cassidy‐Bushrow AE, Bielak LF, Rule AD, et al. Hypertension during pregnancy is associated with coronary artery calcium independent of renal function. J Womens Health (Larchmt). 2009;18:1709–1716.
    1. Mongraw‐Chaffin ML, Cirillo PM, Cohn BA. Preeclampsia and cardiovascular disease death: prospective evidence from the child health and development studies cohort. Hypertension. 2010;56:166–171.
    1. Lin YS, Tang CH, Yang CY, et al. Effect of pre‐eclampsia‐eclampsia on major cardiovascular events among peripartum women in Taiwan. Am J Cardiol. 2011;107:325–330.
    1. Greenland P, LaBree L, Azen SP, et al. Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals. JAMA. 2004;291:210–215.
    1. Wolf M, Kettyle E, Sandler L, et al. Obesity and preeclampsia: the potential role of inflammation. Obstet Gynecol. 2001;98:757–762.
    1. The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cooperative Research Group. Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: preeclampsia. Am J Obstet Gynecol. 2010;202:255e1–255e7.
    1. Duckitt K, Harrington D. Risk factors for pre‐eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330:565.
    1. Paradisi G, Biaggi A, Savone R, et al. Cardiovascular risk factors in healthy women with previous gestational hypertension. J Clin Endocrinol Metab. 2006;91:1233–1238.
    1. Williams D. Pregnancy: a stress test for life. Curr Opin Obstet Gynecol. 2003;15:465–471.
    1. Romundstad PR, Magnussen EB, Smith GD, et al. Hypertension in pregnancy and later cardiovascular risk: common antecedents? Circulation. 2010;122:579–584.
    1. Hamad RR, Eriksson MJ, Silveira A, et al. Decreased flow‐mediated dilation is present 1 year after a pre‐eclamptic pregnancy. J Hypertens. 2007;25:2301–2307.
    1. Klemmensen AK, Olsen SF, Osterdal ML, et al. Validity of preeclampsia‐related diagnoses recorded in a national hospital registry and in a postpartum interview of the women. Am J Epidemiol. 2007;166:117–124.
    1. Diehl CL, Brost BC, Hogan MC, et al. Preeclampsia as a risk factor for cardiovascular disease later in life: validation of a preeclampsia questionnaire. Am J Obstet Gynecol. 2008;198:e11–e13.
    1. Roberts JM, Hubel CA. Pregnancy: a screening test for later life cardiovascular disease. Womens Health Issues. 2010;20:304–307.
    1. Mosca L, Benjamin EJ, Berra K, et al. Effectiveness‐based guidelines for the prevention of cardiovascular disease in women—2011 update: a guideline from the American Heart Association. Circulation. 2011;123:1243–1262.

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