Bioactive Compounds of Strawberry and Blueberry and Their Potential Health Effects Based on Human Intervention Studies: A Brief Overview

Katharina Miller, Walter Feucht, Markus Schmid, Katharina Miller, Walter Feucht, Markus Schmid

Abstract

Strawberries and blueberries are two of the most commonly consumed berries. Berries, in general, are characterized by their highly nutritive compounds, including minerals, vitamins, fatty acids, and dietary fiber, as well as their high content and wide diversity of bioactive compounds, such as phenolic compounds and organic acids. These bioactive compounds have been associated with protective effects against chronic diseases, such as cardiovascular disease, cancer, Alzheimer's and other disorders. In this paper 16 human intervention studies investigating the beneficial health effects of dietary strawberry or blueberry consumption on inflammation, cardiovascular disease or cognitive function and mental health are reviewed.

Keywords: anthocyanidins; berries; cardiovascular disease; inflammation; polyphenols.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. World Health Organization . Global Atlas on Cardiovascular Disease Prevention and Control. World Health Organization; Geneva, Switzerland: 2011.
    1. Forbes-Hernandez T.Y., Gasparrini M., Afrin S., Bompadre S., Mezzetti B., Quiles J.L., Giampieri F., Battino M. The healthy effects of strawberry polyphenols: Which strategy behind antioxidant capacity? Crit. Rev. Food Sci. Nutr. 2016;56(Suppl. 1):46–59. doi: 10.1080/10408398.2015.1051919.
    1. Giampieri F., Forbes-Hernandez T.Y., Gasparrini M., Alvarez-Suarez J.M., Afrin S., Bompadre S., Quiles J.L., Mezzetti B., Battino M. Strawberry as a health promoter: An evidence based review. Food Funct. 2015;6:1386–1398. doi: 10.1039/C5FO00147A.
    1. Joseph S.V., Edirisinghe I., Burton-Freeman B.M. Berries: Anti-inflammatory effects in humans. J. Agric. Food Chem. 2014;62:3886–3903. doi: 10.1021/jf4044056.
    1. Katsiari C.G., Bogdanos D.P., Sakkas L.I. Inflammation and cardiovascular disease. WJTM. 2019;8:1–8. doi: 10.5528/wjtm.v8.i1.1.
    1. Vendrame S., Del Bo C., Ciappellano S., Riso P., Klimis-Zacas D. Berry fruit consumption and metabolic syndrome. Antioxidants. 2016;5:34. doi: 10.3390/antiox5040034.
    1. Khalid S., Barfoot K.L., May G., Lamport D.J., Reynolds S.A., Williams C.M. Effects of Acute Blueberry Flavonoids on Mood in Children and Young Adults. Nutrients. 2017;9:158. doi: 10.3390/nu9020158.
    1. Jimenez-Garcia S.N., Guevara-Gonzalez R.G., Miranda-Lopez R., Feregrino-Perez A.A., Torres-Pacheco I., Vazquez-Cruz M.A. Functional properties and quality characteristics of bioactive compounds in berries: Biochemistry, biotechnology, and genomics. Food Res. Int. 2013;54:1195–1207. doi: 10.1016/j.foodres.2012.11.004.
    1. Shi M., Loftus H., McAinch A.J., Su X.Q. Blueberry as a source of bioactive compounds for the treatment of obesity, type 2 diabetes and chronic inflammation. J. Funct. Foods. 2017;30:16–29. doi: 10.1016/j.jff.2016.12.036.
    1. Caruso G., Villari G., Melchionna G., Conti S. Effects of cultural cycles and nutrient solutions on plant growth, yield and fruit quality of alpine strawberry (Fragaria vesca L.) grown in hydroponics. Sci. Hortic. 2011;129:479–485. doi: 10.1016/j.scienta.2011.04.020.
    1. Conti S., Villari G., Faugno S., Melchionna G., Somma S., Caruso G. Effects of organic vs. conventional farming system on yield and quality of strawberry grown as an annual or biennial crop in southern Italy. Sci. Hortic. 2014;180:63–71. doi: 10.1016/j.scienta.2014.10.015.
    1. Michalska A., Łysiak G. Bioactive Compounds of Blueberries: Post-Harvest Factors Influencing the Nutritional Value of Products. Int. J. Mol. Sci. 2015;16:18642–18663. doi: 10.3390/ijms160818642.
    1. Nile S.H., Park S.W. Edible berries: Bioactive components and their effect on human health. Nutrition. 2014;30:134–144. doi: 10.1016/j.nut.2013.04.007.
    1. Rothwell J.A., Perez-Jimenez J., Neveu V., Medina-Remón A., M’Hiri N., García-Lobato P., Manach C., Knox C., Eisner R., Wishart D.S., et al. Phenol-Explorer 3.0: A major update of the Phenol-Explorer database to incorporate data on the effects of food processing on polyphenol content. Database. 2013;2013 doi: 10.1093/database/bat070.
    1. Nour V., Trandafir I., Cosmulescu S. Antioxidant compounds, nutritional quality and colour of two strawberry genotypes from Fragaria × Ananassa. Erwerbs-Obstbau. 2017;59:123–131. doi: 10.1007/s10341-016-0307-5.
    1. Souci S.W., Fachmann W., Kraut H. Food Composition and Nutrition Tables: Die Zusammensetzung der Lebensmittel, Nährwert-Tabellen = La composition des Aliments, Tableaux des Valeurs Nutritives. 8th ed. MedPharm Scientific Publishers; Stuttgart, Germany: 2016.
    1. Edirisinghe I., Banaszewski K., Cappozzo J., Sandhya K., Ellis C.L., Tadapaneni R., Kappagoda C.T., Burton-Freeman B.M. Strawberry anthocyanin and its association with postprandial inflammation and insulin. Br. J. Nutr. 2011;106:913–922. doi: 10.1017/S0007114511001176.
    1. Ellis C.L., Edirisinghe I., Kappagoda T., Burton-Freeman B. Attenuation of meal-induced inflammatory and thrombotic responses in overweight men and women after 6-week daily strawberry (Fragaria) intake. JAT. 2011;18:318–327. doi: 10.5551/jat.6114.
    1. Park E., Edirisinghe I., Wei H., Vijayakumar L.P., Banaszewski K., Cappozzo J.C., Burton-Freeman B. A dose-response evaluation of freeze-dried strawberries independent of fiber content on metabolic indices in abdominally obese individuals with insulin resistance in a randomized, single-blinded, diet-controlled crossover trial. Mol. Nutr. Food Res. 2016;60:1099–1109. doi: 10.1002/mnfr.201500845.
    1. Zunino S.J., Parelman M.A., Freytag T.L., Stephensen C.B., Kelley D.S., Mackey B.E., Woodhouse L.R., Bonnel E.L. Effects of dietary strawberry powder on blood lipids and inflammatory markers in obese human subjects. Br. J. Nutr. 2012;108:900–909. doi: 10.1017/S0007114511006027.
    1. Basu A., Betts N.M., Nguyen A., Newman E.D., Fu D., Lyons T.J. Freeze-dried strawberries lower serum cholesterol and lipid peroxidation in adults with abdominal adiposity and elevated serum lipids. J. Nutr. 2014;144:830–837. doi: 10.3945/jn.113.188169.
    1. Moazen S., Amani R., Homayouni Rad A., Shahbazian H., Ahmadi K., Taha Jalali M. Effects of freeze-dried strawberry supplementation on metabolic biomarkers of atherosclerosis in subjects with type 2 diabetes: A randomized double-blind controlled trial. Ann. Nutr. Metab. 2013;63:256–264. doi: 10.1159/000356053.
    1. Schell J., Scofield R.H., Barrett J.R., Kurien B.T., Betts N., Lyons T.J., Zhao Y.D., Basu A. Strawberries improve pain and inflammation in obese adults with radiographic evidence of knee osteoarthritis. Nutrients. 2017;9:949. doi: 10.3390/nu9090949.
    1. Bhalodkar N.C., Blum S., Rana T., Bhalodkar A., Kitchappa R., Kim K.-S., Enas E. Comparison of levels of large and small high-density lipoprotein cholesterol in Asian Indian men compared with Caucasian men in the Framingham Offspring Study. Am. J. Cardiol. 2004;94:1561–1563. doi: 10.1016/j.amjcard.2004.08.040.
    1. Cheung C.M., Brown G.B., Wolf A.C., Albers J.J. Altered particle size distribution of apoA-I-containing lipoproteins in subjects with coronary heart disease. J. Lipid Res. 1991;32:383–394.
    1. Zeljkovic A., Vekic J., Spasojevic-Kalimanovska V., Jelic-Ivanovic Z., Bogavac-Stanojevic N., Gulan B., Spasic S. LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality. Atherosclerosis. 2010;210:548–554. doi: 10.1016/j.atherosclerosis.2009.11.040.
    1. Basu A., Morris S., Nguyen A., Betts N.M., Fu D., Lyons T.J. Effects of dietary strawberry supplementation on antioxidant biomarkers in obese adults with above optimal serum lipids. J. Nutr. Metab. 2016 doi: 10.1155/2016/3910630.
    1. Feresin R.G., Johnson S.A., Pourafshar S., Campbell J.C., Jaime S.J., Navaei N., Elam M.L., Akhavan N.S., Alvarez-Alvarado S., Tenenbaum G., et al. Impact of daily strawberry consumption on blood pressure and arterial stiffness in pre- and stage 1-hypertensive postmenopausal women: A randomized controlled trial. Food Funct. 2017;8:4139–4149. doi: 10.1039/C7FO01183K.
    1. Liu S.-X., Yang H.-Y., Li S.-Y., Zhang J.-Y., Li T., Zhu B.-Q., Zhang B.-L. Polyphenolic Compositions and Chromatic Characteristics of Bog Bilberry Syrup Wines. Molecules. 2015;20:19865–19877. doi: 10.3390/molecules201119662.
    1. Stull A.J., Cash K.C., Champagne C.M., Gupta A.K., Boston R., Beyl R.A., Johnson W.D., Cefalu W.T. Blueberries improve endothelial function, but not blood pressure, in adults with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial. Nutrients. 2015;7:4107–4123. doi: 10.3390/nu7064107.
    1. Riso P., Klimis-Zacas D., Del Bo’ C., Martini D., Campolo J., Vendrame S., Møller P., Loft S., de Maria R., Porrini M. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur. J. Nutr. 2013;52:949–961. doi: 10.1007/s00394-012-0402-9.
    1. Stote K.S., Sweeney M.I., Kean T., Baer D.J., Novotny J.A., Shakerley N.L., Chandrasekaran A., Carrico P.M., Melendez J.A., Gottschall-Pass K.T. The effects of 100% wild blueberry (Vaccinium angustifolium) juice consumption on cardiometablic biomarkers: A randomized, placebo-controlled, crossover trial in adults with increased risk for type 2 diabetes. BMC Nutr. 2017;3:524. doi: 10.1186/s40795-017-0164-0.
    1. Johnson S.A., Figueroa A., Navaei N., Wong A., Kalfon R., Ormsbee L.T., Feresin R.G., Elam M.L., Hooshmand S., Payton M.E., et al. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: A randomized, double-blind, placebo-controlled clinical trial. J. Acad. Nutr. Diet. 2015;115:369–377. doi: 10.1016/j.jand.2014.11.001.
    1. Bowtell J.L., Aboo-Bakkar Z., Conway M.E., Adlam A.-L.R., Fulford J. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Appl. Physiol. Nutr. Metab. Physiol. Appl. Nutr. Et Metab. 2017;42:773–779. doi: 10.1139/apnm-2016-0550.
    1. Miller M.G., Hamilton D.A., Joseph J.A., Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur. J. Nutr. 2018;57:1169–1180. doi: 10.1007/s00394-017-1400-8.

Source: PubMed

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