Epidemiology and Burden of Food Allergy

Christopher M Warren, Jialing Jiang, Ruchi S Gupta, Christopher M Warren, Jialing Jiang, Ruchi S Gupta

Abstract

Purpose of review: In recent decades, food allergy has become an increasing concern for families, clinicians, and policymakers. This review aims to summarize what is currently known about the epidemiology and population-level burden of IgE-mediated food allergy, including its effects on quality of life.

Recent findings: Prevalence surveys, healthcare utilization data, and findings from longitudinal cohort studies across the globe indicate that food allergy imposes a growing societal burden. Worryingly, recent data indicate that food allergies may be more prevalent among adult populations than previously acknowledged, with many reported cases of adult-onset allergies. While it remains unclear how much of the current population-level burden of disease results from true, IgE-mediated allergy, as much epidemiological data does not incorporate clinical confirmation of disease prevalence-it is clear that affected individuals suffer impairments in their quality of life and incur substantial economic costs-beyond the physical health burden imposed by anaphylaxis.

Keywords: Burden of disease; Food allergy epidemiology.

Figures

Figure 1.
Figure 1.
Population-based estimates of current pediatric food allergy prevalence in countries around the world

References

    1. Gupta RS, Warren CM, Smith BM, Jiang J, Blumenstock JA, Davis MM, et al. Prevalence and Severity of Food Allergies Among US AdultsPrevalence and Severity of Food Allergies Among US AdultsPrevalence and Severity of Food Allergies Among US Adults. JAMA Network Open. 2019;2(1):e185630–e.
    1. Gupta RS, Warren CM, Smith BM, Blumenstock JA, Jiang J, Davis MM, et al. The Public Health Impact of Parent-Reported Childhood Food Allergies in the United States. Pediatrics. 2018;142(6).
    1. Prevention CfDCa. 2017. National Health Interview Survey (NHIS) Data: Centers for Disease Control and Prevention; 2017 [Available from: .
    1. Hanifin JM, Reed ML. A population-based survey of eczema prevalence in the United States. Dermatitis : contact, atopic, occupational, drug. 2007;18(2):82–91.
    1. Gupta RS, Springston EE, Warrier MR, Smith B, Kumar R, Pongracic J, et al. The Prevalence, Severity, and Distribution of Childhood Food Allergy in the United States. Pediatrics. 2011;128(1):e9–e17.
    1. McGowan EC, Keet CA. Prevalence of self-reported food allergy in the National Health and Nutrition Examination Survey (NHANES) 2007-2010. The Journal of allergy and clinical immunology. 2013;132(5):1216–9.e5.
    1. Verrill L, Bruns R, Luccioli S. Prevalence of self-reported food allergy in U.S. adults: 2001, 2006, and 2010. Allergy Asthma Proc. 2015;36(6):458–67.
    1. Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. The Journal of allergy and clinical immunology. 2010;125(6):1322–6.
    1. Woods RK, Stoney RM, Raven J, Walters EH, Abramson M, Thien FC. Reported adverse food reactions overestimate true food allergy in the community. European journal of clinical nutrition. 2002;56(1):31–6.
    1. Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Lowe AJ, Matheson MC, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. The Journal of allergy and clinical immunology. 2011;127(3):668-76.e1-2.
    1. Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. The Journal of allergy and clinical immunology. 2017;140(1):145–53.e8.
    1. Schoemaker AA, Sprikkelman AB, Grimshaw KE, Roberts G, Grabenhenrich L, Rosenfeld L, et al. Incidence and natural history of challenge-proven cow’s milk allergy in European children--EuroPrevall birth cohort. Allergy. 2015;70(8):963–72.
    1. Xepapadaki P, Fiocchi A, Grabenhenrich L, Roberts G, Grimshaw KE, Fiandor A, et al. Incidence and natural history of hen’s egg allergy in the first 2 years of life-the EuroPrevall birth cohort study. Allergy. 2016;71(3):350–7.
    1. Kelleher MM, Dunn-Galvin A, Gray C, Murray DM, Kiely M, Kenny L, et al. Skin barrier impairment at birth predicts food allergy at 2 years of age. The Journal of allergy and clinical immunology. 2016;137(4):1111–6.e8.
    1. Soller L, Ben-Shoshan M, Harrington DW, Fragapane J, Joseph L, St-Pierre Y, et al. Overall Prevalence Of Self-reported Food Allergy In Canada. Journal of Allergy and Clinical Immunology. 2012;129(2):AB234.
    1. Ontiveros N, Valdez-Meza EE, Vergara-Jimenez MJ, Canizalez-Roman A, Borzutzky A, Cabrera-Chavez F. Parent-reported prevalence of food allergy in Mexican schoolchildren: A population-based study. Allergologia et immunopathologia. 2016;44(6):563–70.
    1. Gonzales-González VA, Díaz AM, Fernández K, Rivera MF. Prevalence of food allergens sensitization and food allergies in a group of allergic Honduran children. Allergy Asthma Clin Immunol. 2018;14:23-.
    1. Bachiloglu R, Ivanovic-Zuvic D, Alvarez J, Linn K, Thone N, de los Angeles Paul M, et al. Prevalence of parent-reported immediate hypersensitivity food allergy in Chilean school-aged children. Allergologia et immunopathologia. 2014;42(6):527–32.
    1. Goncalves LC, Guimaraes TC, Silva RM, Cheik MF, de Ramos Napolis AC, Barbosa ESG, et al. Prevalence of food allergy in infants and pre-schoolers in Brazil. Allergologia et immunopathologia. 2016;44(6):497–503.
    1. Al-Hammadi S, Al-Maskari F, Bernsen R. Prevalence of food allergy among children in Al-Ain city, United Arab Emirates. International archives of allergy and immunology. 2010;151(4):336–42.
    1. Ali F A Survey of Self-Reported Food Allergy and Food-Related Anaphylaxis among Young Adult Students at Kuwait University, Kuwait. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2017;26(3):229–34.
    1. Irani C, Maalouly G. Prevalence of Self-Reported Food Allergy in Lebanon: A Middle-Eastern Taste. Int Sch Res Notices. 2015;2015:639796-.
    1. Graif Y, German L, Livne I, Shohat T. Association of food allergy with asthma severity and atopic diseases in Jewish and Arab adolescents. Acta paediatrica (Oslo, Norway : 1992). 2012;101(10):1083–8.
    1. Orhan F, Karakas T, Cakir M, Aksoy A, Baki A, Gedik Y. Prevalence of immunoglobulin E-mediated food allergy in 6-9-year-old urban schoolchildren in the eastern Black Sea region of Turkey. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2009;39(7):1027–35.
    1. Caffarelli C, Coscia A, Ridolo E, Povesi Dascola C, Gelmett C, Raggi V, et al. Parents’ estimate of food allergy prevalence and management in Italian school-aged children. Pediatrics international : official journal of the Japan Pediatric Society. 2011;53(4):505–10.
    1. Steinke M, Fiocchi A, Kirchlechner V, Ballmer-Weber B, Brockow K, Hischenhuber C, et al. Perceived food allergy in children in 10 European nations. A randomised telephone survey. International archives of allergy and immunology. 2007;143(4):290–5.
    1. Perkin MR, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. The New England journal of medicine. 2016;374(18):1733–43.
    1. Protudjer JLP, Vetander M, Kull I, Hedlin G, van Hage M, Wickman M, et al. Food-Related Symptoms and Food Allergy in Swedish Children from Early Life to Adolescence. PLoS One. 2016;11(11):e0166347–e.
    1. Kvenshagen B, Halvorsen R, Jacobsen M. Is there an increased frequency of food allergy in children delivered by caesarean section compared to those delivered vaginally? Acta paediatrica (Oslo, Norway : 1992). 2009;98(2):324–7.
    1. Rance F, Grandmottet X, Grandjean H. Prevalence and main characteristics of schoolchildren diagnosed with food allergies in France. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2005;35(2):167–72.
    1. Saleh-Langenberg J, Bootsma GM, van Ginkel CD, Kollen BJ, Flokstra-de Blok BM, Dubois AE. The prevalence of food allergy and epinephrine auto-injectors in Dutch food-allergic adolescents. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2016;27(7):755–9.
    1. Gaspar-Marques J, Carreiro-Martins P, Papoila AL, Caires I, Pedro C, Araujo-Martins J, et al. Food allergy and anaphylaxis in infants and preschool-age children. Clinical pediatrics. 2014;53(7):652–7.
    1. Baricic TV, Catipovic M, Cetinic EL, Krmek V, Horvat I. Parental Perception, Prevalence and Primary Care Physicians’ Knowledge on Childhood Food Allergy in Croatia. Children (Basel, Switzerland). 2015;2(3):305–16.
    1. Papathoma E, Triga M, Fouzas S, Dimitriou G. Cesarean section delivery and development of food allergy and atopic dermatitis in early childhood. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2016;27(4):419–24.
    1. Thrastardottir AR, Thordardottir FR, Torfadottir J. [Protocols Related to Food Allergies and Intolerances in Preschools in Reykjavik, Iceland]. Laeknabladid. 2018;104(1):11–7.
    1. Roehr CC, Edenharter G, Reimann S, Ehlers I, Worm M, Zuberbier T, et al. Food allergy and non-allergic food hypersensitivity in children and adolescents. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2004;34(10):1534–41.
    1. Krause TG, Koch A, Poulsen LK, Kristensen B, Olsen OR, Melbye M. Atopic sensitization among children in an Arctic environment. Clinical & Experimental Allergy. 2002;32(3):367–72.
    1. Pyrhönen K, Hiltunen L, Kaila M, Näyhä S, Läärä E. Heredity of food allergies in an unselected child population: An epidemiological survey from Finland. Pediatric Allergy and Immunology. 2011;22(1pt2):e124–e32.
    1. Obeng BB, Amoah AS, Larbi IA, Yazdanbakhsh M, van Ree R, Boakye DA, et al. Food allergy in Ghanaian schoolchildren: data on sensitization and reported food allergy. International archives of allergy and immunology. 2011;155(1):63–73.
    1. Basera W, Botha M, Gray CL, Lunjani N, Watkins AS, Venter C, et al. The South African Food Sensitisation and Food Allergy population-based study of IgE-mediated food allergy: validity, safety, and acceptability. Ann Allergy Asthma Immunol. 2015;115(2):113–9.
    1. Kung S-J, Steenhoff AP, Gray C. Food Allergy in Africa: Myth or Reality? Clinical Reviews in Allergy & Immunology. 2014;46(3):241–9.
    1. Hu Y, Chen J, Li H. Comparison of food allergy prevalence among Chinese infants in Chongqing, 2009 versus 1999. Pediatrics International. 2010;52(5):820–4.
    1. Lee AJ, Shek LP-C. Food allergy in Singapore: opening a new chapter. Singapore Med J. 2014;55(5):244–7.
    1. Kim J, Chang E, Han Y, Ahn K, Lee SI. The incidence and risk factors of immediate type food allergy during the first year of life in Korean infants: a birth cohort study. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2011;22(7):715–9.
    1. Noda R Prevalence of food allergy in nursery school (nationwide survey). Jpn J Food Allergy. 2010:5–9.
    1. Ho MH, Lee SL, Wong WH, Ip P, Lau YL. Prevalence of self-reported food allergy in Hong Kong children and teens--a population survey. Asian Pacific journal of allergy and immunology. 2012;30(4):275–84.
    1. Wu TC, Tsai TC, Huang CF, Chang FY, Lin CC, Huang IF, et al. Prevalence of food allergy in Taiwan: a questionnaire-based survey. Internal medicine journal. 2012;42(12):1310–5.
    1. Lao-araya M, Trakultivakorn M. Prevalence of food allergy among preschool children in northern Thailand. Pediatrics international : official journal of the Japan Pediatric Society. 2012;54(2):238–43.
    1. Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby A-L, et al. The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up. Journal of Allergy and Clinical Immunology. 2017;140(1):145–53.e8.
    1. Ho MHK, Wong WHS, Heine RG, Hosking CS, Hill DJ, Allen KJ. Early clinical predictors of remission of peanut allergy in children. Journal of Allergy and Clinical Immunology. 2008;121(3):731–6.
    1. Boyano-Martínez T, García-Ara C, Díaz-Pena JM, Martín-Esteban M. Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. Journal of Allergy and Clinical Immunology. 2002;110(2):304–9.
    1. Venkataraman D, Erlewyn-Lajeunesse M, Kurukulaaratchy RJ, Potter S, Roberts G, Matthews S, et al. Prevalence and longitudinal trends of food allergy during childhood and adolescence: Results of the Isle of Wight Birth Cohort study. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2018;48(4):394–402.
    1. Taylor-Black S, Wang J. The prevalence and characteristics of food allergy in urban minority children. Ann Allergy Asthma Immunol. 2012;109(6):431–7.
    1. Sicherer SH, Muñoz-Furlong A, Sampson HA. Prevalence of seafood allergy in the United States determined by a random telephone survey. Journal of Allergy and Clinical Immunology. 2004;114(1):159–65.
    1. Luccioli S, Ross M, Labiner-Wolfe J, Fein SB. Maternally reported food allergies and other food-related health problems in infants: characteristics and associated factors. Pediatrics. 2008;122 Suppl 2:S105–12.
    1. Branum AM, Lukacs SL. Food allergy among children in the United States. Pediatrics. 2009;124(6):1549–55.
    1. Mahdavinia M, Fox SR, Smith BM, James C, Palmisano EL, Mohammed A, et al. Racial Differences in Food Allergy Phenotype and Health Care Utilization among US Children. The journal of allergy and clinical immunology In practice. 2017;5(2):352–7.e1.
    1. Sicherer SH, Wood RA, Stablein D, Lindblad R, Burks AW, Liu AH, et al. Maternal consumption of peanut during pregnancy is associated with peanut sensitization in atopic infants. The Journal of allergy and clinical immunology. 2010;126(6):1191–7.
    1. Liu AH, Jaramillo R, Sicherer SH, Wood RA, Bock SA, Burks AW, et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 2005-2006. The Journal of allergy and clinical immunology. 2010;126(4):798–806.e13.
    1. Joseph CL, Zoratti EM, Ownby DR, Havstad S, Nicholas C, Nageotte C, et al. Exploring racial differences in IgE-mediated food allergy in the WHEALS birth cohort. Ann Allergy Asthma Immunol. 2016;116(3):219–24.e1.
    1. Keet CA, Wood RA, Matsui EC. Limitations of reliance on specific IgE for epidemiologic surveillance of food allergy. The Journal of allergy and clinical immunology. 2012;130(5):1207–9.e10.
    1. McGowan EC, Peng RD, Salo PM, Zeldin DC, Keet CA. Changes in Food-Specific IgE Over Time in the National Health and Nutrition Examination Survey (NHANES). The journal of allergy and clinical immunology In practice. 2016;4(4):713–20.
    1. Turner PJ, Jerschow E, Umasunthar T, Lin R, Campbell DE, Boyle RJ. Fatal Anaphylaxis: Mortality Rate and Risk Factors. The journal of allergy and clinical immunology In practice. 2017;5(5):1169–78.
    1. Umasunthar T, Leonardi-Bee J, Hodes M, Turner PJ, Gore C, Habibi P, et al. Incidence of fatal food anaphylaxis in people with food allergy: a systematic review and meta-analysis. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2013;43(12):1333–41.
    1. Turner PJ, Gowland MH, Sharma V, Ierodiakonou D, Harper N, Garcez T, et al. Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992-2012. The Journal of allergy and clinical immunology. 2015;135(4):956–63.e1.
    1. Kivisto JE, Protudjer JL, Karjalainen J, Wickman M, Bergstrom A, Mattila VM. Hospitalizations due to allergic reactions in Finnish and Swedish children during 1999-2011. Allergy. 2016;71(5):677–83.
    1. Poulos LM, Waters AM, Correll PK, Loblay RH, Marks GB. Trends in hospitalizations for anaphylaxis, angioedema, and urticaria in Australia, 1993-1994 to 2004-2005. The Journal of allergy and clinical immunology. 2007;120(4):878–84.
    1. Mullins RJ, Dear KB, Tang ML. Time trends in Australian hospital anaphylaxis admissions in 1998-1999 to 2011-2012. The Journal of allergy and clinical immunology. 2015;136(2):367–75.
    1. Dyer AA, Lau CH, Smith TL, Smith BM, Gupta RS. Pediatric emergency department visits and hospitalizations due to food-induced anaphylaxis in Illinois. Ann Allergy Asthma Immunol. 2015;115(1):56–62.
    1. Bohlke K, Davis RL, DeStefano F, Marcy SM, Braun MM, Thompson RS. Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization. Journal of Allergy and Clinical Immunology. 2004;113(3):536–42.
    1. Lieberman J, Sublett J, Ali Y, Haselkorn T, Damle V, Chidambaram A, et al. INCREASED INCIDENCE AND PREVALENCE OF PEANUT ALLERGY IN CHILDREN AND ADOLESCENTS IN THE UNITED STATES. Annals of Allergy, Asthma & Immunology. 2018;121(5, Supplement):S13.
    1. FAIR Health I Food Allergy in the United States: Recent Trends and Costs 2017.
    1. Motosue MS, Bellolio MF, Van Houten HK, Shah ND, Campbell RL. National trends in emergency department visits and hospitalizations for food-induced anaphylaxis in US children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2018;29(5):538–44.
    1. Gupta RS, Springston EE, Smith B, Warrier MR, Pongracic J, Holl JL. Geographic variability of childhood food allergy in the United States. Clinical pediatrics. 2012;51(9):856–61.
    1. Botha M, Basera W, Facey-Thomas HE, Gaunt B, Gray CL, Ramjith J, et al. Rural and urban food allergy prevalence from the South African Food Allergy (SAFFA) study. The Journal of allergy and clinical immunology. 2019;143(2):662–8.e2.
    1. Tang ML, Mullins RJ. Food allergy: is prevalence increasing? Internal medicine journal. 2017;47(3):256–61.
    1. Mahesh PA, Wong GW, Ogorodova L, Potts J, Leung TF, Fedorova O, et al. Prevalence of food sensitization and probable food allergy among adults in India: the EuroPrevall INCO study. Allergy. 2016;71(7):1010–9.
    1. Tham EH, Loo EXL, Zhu Y, Shek LPC. Effects of Migration on Allergic Diseases. International archives of allergy and immunology. 2019;178(2):128–40.
    1. Koplin JJ, Peters RL, Ponsonby AL, Gurrin LC, Hill D, Tang ML, et al. Increased risk of peanut allergy in infants of Asian-born parents compared to those of Australian-born parents. Allergy. 2014;69(12):1639–47.
    1. Panjari M, Koplin JJ, Dharmage SC, Peters RL, Gurrin LC, Sawyer SM, et al. Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2016;46(4):602–9.
    1. National Research Council (US) Panel on Race E, and Health in Later Life. 7. Immigrant Health: Selectivity and Acculturation. . Anderson NBBR, Cohen B, editor. Washington (DC): National Academies Press; 2004.
    1. Allen KJ, Koplin JJ. What can urban/rural differences in food allergy prevalence tell us about the drivers of food allergy? Journal of Allergy and Clinical Immunology. 2019;143(2):554–6.
    1. Allen CW, Bidarkar MS, vanNunen SA, Campbell DE. Factors impacting parental burden in food-allergic children. Journal of Paediatrics and Child Health. 2015;51(7):696–8.
    1. Wassenberg J, Cochard M-M, DunnGalvin A, Ballabeni P, Flokstra-de Blok BMJ, Newman CJ, et al. Parent perceived quality of life is age-dependent in children with food allergy. Pediatric Allergy and Immunology. 2012;23(5):412–9.
    1. Howe L, Franxman T, Teich E, Greenhawt M. What affects quality of life among caregivers of food-allergic children? Annals of Allergy, Asthma & Immunology. 2014;113(1):69–74.e2.
    1. Ward CE, Greenhawt MJ. Treatment of allergic reactions and quality of life among caregivers of food-allergic children. Annals of Allergy, Asthma & Immunology. 2015;114(4):312–8.e2.
    1. Warren CM, Gupta RS, Sohn M-W, Oh EH, Lai N, Garfield CF, et al. Differences in empowerment and quality of life among parents of children with food allergy. Annals of Allergy, Asthma & Immunology. 2015;114(2):117–25.e3.
    1. Chow C, Pincus DB, Comer JS. Pediatric Food Allergies and Psychosocial Functioning: Examining the Potential Moderating Roles of Maternal Distress and Overprotection. Journal of Pediatric Psychology. 2015;40(10):1065–74.
    1. Warren CM, Otto AK, Walkner MM, Gupta RS. Quality of Life Among Food Allergic Patients and Their Caregivers. Current allergy and asthma reports. 2016;16(5):38.
    1. Gupta R, Holdford D, Bilaver L, Dyer A, Holl JL, Meltzer D. The economic impact of childhood food allergy in the United States. JAMA pediatrics. 2013;167(11):1026–31.
    1. Bilaver LA, Kester KM, Smith BM, Gupta RS. Socioeconomic Disparities in the Economic Impact of Childhood Food Allergy. Pediatrics. 2016;137(5).
    1. Bilaver LA, Chadha AS, Doshi P, O’Dwyer L, Gupta RS. Economic burden of food allergy: A systematic review. Ann Allergy Asthma Immunol. 2019;122(4):373–80.e1.

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