Abatacept and sodium thiosulfate for treatment of recalcitrant juvenile dermatomyositis complicated by ulceration and calcinosis

Abstract

We report the successful use of abatacept and sodium thiosulfate in a patient with severe recalcitrant juvenile dermatomyositis complicated by ulcerative skin disease and progressive calcinosis. This combination therapy resulted in significant reductions in muscle and skin inflammation, decreased corticosteroid dependence, and halted the progression of calcinosis.

Conflict of interest statement

The authors declare no conflicts of interest.

Copyright © 2012 Mosby, Inc. All rights reserved.

Figures

Figure

Ischemic cutaneous ulcerations and calcinosis noted at A, 30 months after diagnosis at the start of, and B, 6 months post treatment with topical and IV sodium thiosulfate and abatacept. There was progressive softening of calcinotic areas and healing of associated ulcerations.