Site of Alcohol First-Pass Metabolism Among Women

Neda Seyedsadjadi, M Belen Acevedo, Raul Alfaro, Vijay A Ramchandani, Martin H Plawecki, Blair Rowitz, Marta Yanina Pepino, Neda Seyedsadjadi, M Belen Acevedo, Raul Alfaro, Vijay A Ramchandani, Martin H Plawecki, Blair Rowitz, Marta Yanina Pepino

Abstract

This cross-sectional study compares alcohol pharmacokinetics in patients who underwent sleeve gastrectomy with control participants who did not undergo surgery.

Conflict of interest statement

Conflict of Interest Disclosures: Dr Plawecki reported receiving grants from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) during the conduct of the study. Dr Rowitz reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study. Dr Pepino reported grants from NIAAA/NIH during the conduct of the study. No other disclosures were reported.

Figures

Figure.. Blood Alcohol Concentrations (BACs) for Sleeve…
Figure.. Blood Alcohol Concentrations (BACs) for Sleeve Gastrectomy (SG) Group and Nonoperated Control Group
A, SG group included 12 women, and control group included 9 women. B and D, Area under the curve (AUC) for concentration-time curves for both groups. Whiskers indicate SEM. C, SG and control group participants were matched on time-to-peak BAC. Analysis was conducted among 7 women from each group. E and F, Individual BAC curves. aValue significantly different from control group at P < .05.

References

    1. Caballeria J, Frezza M, Hernández-Muñoz R, et al. . Gastric origin of the first-pass metabolism of ethanol in humans: effect of gastrectomy. Gastroenterology. 1989;97(5):1205-1209. doi:10.1016/0016-5085(89)91691-0
    1. Acevedo MB, Teran-Garcia M, Bucholz KK, et al. . Alcohol sensitivity in women after undergoing bariatric surgery: a cross-sectional study. Surg Obes Relat Dis. 2020;16(4):536-544. doi:10.1016/j.soard.2020.01.014
    1. Mellinger JL, Shedden K, Winder GS, et al. . Bariatric surgery and the risk of alcohol-related cirrhosis and alcohol misuse. Liver Int. 2021;41(5):1012-1019. doi:10.1111/liv.14805
    1. King WC, Chen JY, Mitchell JE, et al. . Prevalence of alcohol use disorders before and after bariatric surgery. JAMA. 2012;307(23):2516-2525. doi:10.1001/jama.2012.6147
    1. Levitt MD, Levitt DG. Appropriate use and misuse of blood concentration measurements to quantitate first-pass metabolism. J Lab Clin Med. 2000;136(4):275-280. doi:10.1067/mlc.2000.109100
    1. Ramchandani VA, O’Connor S. Studying alcohol elimination using the alcohol clamp method. Alcohol Res Health. 2006;29(4):286-290.

Source: PubMed

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

3
Abonner