Vertical Transmission of Gut Microbiome and Antimicrobial Resistance Genes in Infants Exposed to Antibiotics at Birth
Weizhong Li, Terhi Tapiainen, Lauren Brinkac, Hernan A Lorenzi, Kelvin Moncera, Mysore V Tejesvi, Jarmo Salo, Karen E Nelson, Weizhong Li, Terhi Tapiainen, Lauren Brinkac, Hernan A Lorenzi, Kelvin Moncera, Mysore V Tejesvi, Jarmo Salo, Karen E Nelson
Abstract
Vertical transmission of maternal microbes is a major route for establishing the gut microbiome in newborns. The impact of perinatal antibiotics on vertical transmission of microbes and antimicrobial resistance is not well understood. Using a metagenomic approach, we analyzed the fecal samples from mothers and vaginally delivered infants from a control group (10 pairs) and a treatment group (10 pairs) receiving perinatal antibiotics. Antibiotic-usage had a significant impact on the main source of inoculum in the gut microbiome of newborns. The control group had significantly more species transmitted from mothers to infants (P = .03) than the antibiotic-treated group. Approximately 72% of the gut microbial population of infants at 3-7 days after birth in the control group was transmitted from their mothers, versus only 25% in the antibiotic-treated group. In conclusion, perinatal antibiotics markedly disturbed vertical transmission and changed the source of gut colonization towards horizontal transfer from the environment to the infants.
Keywords: AMR; antibiotics; antimicrobial resistance genes; gut microbiome; infant microbiome; microbiome; microbiome transmission.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
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References
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