Vitamin D Uptake in Patients Treated with a High-Dosed Purified Omega-3 Compound in a Randomized Clinical Trial Following an Acute Myocardial Infarction

Patrycja A Naesgaard, Heidi Grundt, Arne F Nordøy, Harry Staines, Dennis W T Nilsen, Patrycja A Naesgaard, Heidi Grundt, Arne F Nordøy, Harry Staines, Dennis W T Nilsen

Abstract

Background: Fish is the natural dietary source of vitamin D. Reports on the influence of purified omega-3 fatty acids on its uptake are scarce.

Objectives: We investigated the impact of a purified high-dose omega-3 compound compared to corn oil on 25-hydroxyvitamin D [25(OH)D] levels following an acute myocardial infarction.

Methods: 228 patients were randomized 1:1 to receive a daily dose of either 4 g omega-3 (OMACOR®) or an equal dose of corn oil, administered double-blindly for 12 months. Total omega-3 and omega-6 measurements were available in 40 randomly picked patients.

Results: There was no significant intergroup difference in 25(OH)D changes at 12 months follow-up (p = 0.12), but there was a minor statistical significant intragroup increase in 25(OH)D in both intervention arms (p < 0.001 for n-3 polyunsaturated fatty acids and p = 0.013 for corn oil, respectively). A positive correlation was noted between 25(OH)D and omega-3 prior to inclusion; r = 0.418, p = 0.007, attenuated at 12 months by purified omega-3 intervention; r = 0.021, p = 0.93. No positive correlation was observed between omega-6 and 25(OH)D.

Conclusion: Long-term treatment with a high dose of purified omega-3 as compared to corn oil did not improve serum concentrations of vitamin D.

Clinical trial registration: ClinicalTrials.gov, Identifier: NCT01422317.

Keywords: 25-hydroxyvitamin D; acute myocardial infarction; omega-3; omega-6; vitamin D.

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Flow chart.

References

    1. DeLuca HF. Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr (2004) 80:1689S–96S.
    1. Grossmann RE, Tangpricha V. Evaluation of vehicle substances on vitamin D bioavailability: a systematic review. Mol Nutr Food Res (2010) 54:1055–61.10.1002/mnfr.200900578
    1. Naesgaard PA, León De La Fuente RA, Nilsen ST, Woie L, Aarsland T, Brede C, et al. Serum 25(OH)D is a 2-year predictor of all-cause mortality, cardiac death and sudden cardiac death in chest pain patients from Northern Argentina. PLoS One (2012) 7:e43228.10.1371/journal.pone.0043228
    1. Judd SE, Tangpricha V. Vitamin D deficiency and risk for cardiovascular disease. Am J Med Sci (2009) 338:40–4.10.1097/MAJ.0b013e3181aaee91
    1. Aarsetoey H, Grundt H, Nygaard O, Nilsen DW. The role of long-chained marine N-3 polyunsaturated fatty acids in cardiovascular disease. Cardiol Res Pract (2012) 2012:303456.10.1155/2012/303456
    1. Nilsen DWT, Albrektsen G, Landmark K, Moen S, Aarsland T, Woie L. Effects of a highdose concentrate of n-3 fatty acids or corn oil introduced early after an acute myocardial infarction on serum triacylglycerol and HDL cholesterol. Am J Clin Nutr (2001) 74:50–6.
    1. Grundt H, Nilsen DWT, Mansoor MA, Nordøy A. Increased lipid peroxidation during long-term intervention with high doses of n-3 fatty acids (PUFAs) following an acute myocardial infarction. Eur J Clin Nutr (2003) 57:793–800.10.1038/sj.ejcn.1601730
    1. Holvik K, Madar AA, Meyer HE, Lofthus CM, Stene LC. A randomised comparison of increase in serum 25-hydroxyvitamin D concentration after 4 weeks of daily oral intake of 10 microg cholecalciferol from multivitamin tablets or fish oil capsules in healthy young adults. Br J Nutr (2007) 98:620–5.10.1017/S000711450773074X
    1. Grundt H, Nilsen DW, Mansoor MA, Hetland Ø, Nordøy A. Reduction in homocysteine by n-3 polyunsaturated fatty acids after 1 year in a randomised double-blind study following an acute myocardial infarction: no effect on endothelial adhesion properties. Pathophysiol Haemost Thromb (2003) 33:88–95.10.1159/000073852
    1. Agborsangaya C, Toriola AT, Grankvist K, Surcel HM, Holl K, Parkkila S, et al. The effects of storage time and sampling season on the stability of serum 25-hydroxyvitamin D and androstenedione. Nutr Cancer (2010) 62:51–7.10.1080/01635580903191460
    1. Nordøy A, Bønaa KH, Nilsen H, Berge RK, Hansen JB, Ingebretsen OC. Effects of Simvastatin and omega-3 fatty acids on plasma lipoproteins and lipid peroxidation in patients with combined hyperlipidaemia. J Intern Med (1998) 243:163–70.10.1046/j.1365-2796.1998.00297.x
    1. Dawson-Hughes B, Harris SS, Lichtenstein AH, Dolnikowski G, Palermo NJ, Rasmussen H. Dietary fat increases vitamin D-3 absorption. J Acad Nutr Diet (2015) 115:225–30.10.1016/j.jand.2014.09.014
    1. Itariu BK, Zeyda M, Leitner L, Marculescu R, Stulnig TM. Treatment with n-3 polyunsaturated fatty acids overcomes the inverse association of vitamin D deficiency with inflammation in severely obese patients: a randomized controlled trial. PLoS One (2013) 8:e54634.10.1371/journal.pone.0054634
    1. Tangpricha V, Koutkia P, Rieke SM, Chen TC, Perez AA, Holick MF. Fortification of orange juice with vitamin D: a novel approach for enhancing vitamin D nutritional health. Am J Clin Nutr (2003) 77:1478–83.
    1. Olsen KS, Aksnes L, Frøyland L, Lund E, Rylander C. Vitamin D status and PUFA ratios in a national representative cross-section of healthy, middle-aged Norwegian women – the Norwegian Women and Cancer Post-Genome Cohort. Scand J Public Health (2014) 42:814–20.10.1177/1403494814550519
    1. Burr ML, Fehily AM, Gilbert JF, Rogers S, Holliday RM, Sweetnam PM, et al. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: diet and reinfarction trial (DART). Lancet (1989) 2:757–61.10.1016/S0140-6736(89)90828-3
    1. Kromhout D, Giltay EJ, Geleijnse JM, Alpha Omega Trial Group n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med (2010) 363:2015–26.10.1056/NEJMoa1003603
    1. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, et al. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center-based (JPHC) study cohort I. Circulation (2006) 113:195–202.10.1161/CIRCULATIONAHA.105.581355
    1. The ORIGIN Trial Investigators. n-3 fatty acids and cardiovascular outcomes in patients with dysglycemia. N Engl J Med (2012) 367:1760–1.10.1056/NEJMc1210552
    1. Marchioli R. Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-prevenzione trial. Lancet (1999) 354:447–55.10.1016/S0140-6736(99)07072-5
    1. Gissi-HF Investigators. Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet (2008) 372:1223–30.10.1016/S0140-6736(08)61239-8
    1. ASCEND. A Study of Cardiovascular Events in Diabetes 2011. Available from: . Accessed July 1, 2011
    1. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet (2007) 369:1090–8.10.1016/S0140-6736(07)60527-3
    1. Kwak SM, Myung SK, Lee YJ, Seo HG, Korean Meta-analysis Study Group . Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a meta-analysis of randomized, double-blind, placebo-controlled trials. Arch Intern Med (2012) 172:686–94.10.1001/archinternmed.2012.262
    1. Chowdhury R, Warnakula S, Kunutsor S, Crowe F, Ward HA, Johnson L, et al. Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med (2014) 160:398–406.10.7326/M13-1788

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