Non invasive ventilation as an additional tool for exercise training

Nicolino Ambrosino, Paolo Cigni, Nicolino Ambrosino, Paolo Cigni

Abstract

Recently, there has been increasing interest in the use of non invasive ventilation (NIV) to increase exercise capacity. In individuals with COPD, NIV during exercise reduces dyspnoea and increases exercise tolerance. Different modalities of mechanical ventilation have been used non-invasively as a tool to increase exercise tolerance in COPD, heart failure and lung and thoracic restrictive diseases. Inspiratory support provides symptomatic benefit by unloading the ventilatory muscles, whereas Continuous Positive Airway Pressure (CPAP) counterbalances the intrinsic positive end-expiratory pressure in COPD patients. Severe stable COPD patients undergoing home nocturnal NIV and daytime exercise training showed some benefits. Furthermore, it has been reported that in chronic hypercapnic COPD under long-term ventilatory support, NIV can also be administered during walking. Despite these results, the role of NIV as a routine component of pulmonary rehabilitation is still to be defined.

Keywords: COPD; Chronic heart failure; Dyspnoea; Pulmonary rehabilitation.

References

    1. O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164:770–7. doi: 10.1164/ajrccm.164.5.2012122.
    1. Babb TG, Viggiano R, Hurley B, Staats B, Rodarte JR. Effect of mild-to-moderate airflow limitation on exercise capacity. J Appl Physiol. 1991;70:223–30.
    1. Marin JM, Carrizo SJ, Gascon M, Sanchez A, Gallego B, Celli BR. Inspiratory capacity, dynamic hyperinflation, breathlessness, and exercise performance during the 6-minute-walk test in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163:1395–9. doi: 10.1164/ajrccm.163.6.2003172.
    1. Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188:e13–64. doi: 10.1164/rccm.201309-1634ST.
    1. Vogiatzis I, Zakynthinos S. The physiological basis of rehabilitation in chronic heart and lung disease. J Appl Physiol. 2013;115:16–21. doi: 10.1152/japplphysiol.00195.2013.
    1. Ambrosino N, Strambi S. New strategies to improve exercise tolerance in chronic obstructive pulmonary disease. Eur Respir J. 2004;24:313–22. doi: 10.1183/09031936.04.00002904.
    1. Ambrosino N, Guarracino F. Unusual applications of non-invasive ventilation. Eur Respir J. 2011;38:440–9. doi: 10.1183/09031936.00192810.
    1. Hill K, Holland AE. Strategies to enhance the benefits of exercise training in the respiratory patient. Clin Chest Med. 2014;35:323–36. doi: 10.1016/j.ccm.2014.02.003.
    1. Harms CA, Babcock MA, McClaran SR, Pegelow DF, Nickele GA, Nelson WB, et al. Respiratory muscle work compromises leg blood flow during maximal exercise. J Appl Physiol. 1997;82:1573–83.
    1. Harms CA, Wetter TJ, St Croix CM, Pegelow DF, Dempsey JA. Effects of respiratory muscle work on exercise performance. J Appl Physiol. 2000;89:131–8.
    1. Babcock MA, Pegelow DF, Harms CA, Dempsey JA. Effects of respiratory muscle unloading on exercise induced diaphragm fatigue. J Appl Physiol. 2002;93:201–6. doi: 10.1152/japplphysiol.00612.2001.
    1. Borghi-Silva A, Oliveira CC, Carrascosa C, Maia J, Berton DC, Queiroga F, Jr, et al. Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD. Thorax. 2008;63:910–5. doi: 10.1136/thx.2007.090167.
    1. Franssen FME, Rochester CL. Comorbidities in patients with COPD and pulmonary rehabilitation: do they matter? Eur Respir Rev. 2014;23:131–41. doi: 10.1183/09059180.00007613.
    1. Hannink JD, van Hees HW, Dekhuijzen PN, van Helvoort HA, Heijdra YF. Non-invasive ventilation abolishes the IL-6 response to exercise in muscle-wasted COPD patients: a pilot study. Scand J Med Sci Sports. 2014;24:136–43. doi: 10.1111/j.1600-0838.2012.01484.x.
    1. Borghi-Silva A, Silva Reis M, Goncalves Mendes R, Falasco Pantoni CB, Polaquini Simoes R, Barreto Martins LE, et al. Noninvasive ventilation acutely modifies heart rate variability in chronic obstructive pulmonary disease patients. Respir Med. 2008;102:1117–23. doi: 10.1016/j.rmed.2008.03.016.
    1. Bündchen DC, Gonzáles AI, Noronha MD, Brüggemann AK, Sties SW, Carvalho TD. Noninvasive ventilation and exercise tolerance in heart failure: A systematic review and meta-analysis. Braz J Phys Ther. 2014;18:385–94. doi: 10.1590/bjpt-rbf.2014.0039.
    1. Ambrosino N, Palmiero G, Strambi S. New approaches in pulmonary rehabilitation. Clin Chest Med. 2007;28:629–38. doi: 10.1016/j.ccm.2007.06.001.
    1. O’Donnell DE, Sanii R, Younes M. Improvement in exercise endurance in patients with chronic airflow limitation using continuous positive airway pressure. Am Rev Respir Dis. 1988;138:1510–4. doi: 10.1164/ajrccm/138.6.1510.
    1. O’Donnell DE, Sanii R, Giesbrecht G, Younes M. Effect of continuous positive airway pressure on respiratory sensation in patients with chronic obstructive pulmonary disease during submaximal exercise. Am Rev Respir Dis. 1988;138:1185–91. doi: 10.1164/ajrccm/138.5.1185.
    1. Petrof BJ, Calderini E, Gottfried SB. Effect of CPAP on respiratory effort and dyspnoea during exercise in severe COPD. J Appl Physiol. 1990;69:179–88.
    1. Rossi A, Polese G, Brandi G, Conti G. Intrinsic positive end-expiratory pressure (PEEPi) Intensive Care Med. 1995;21:522–36. doi: 10.1007/BF01706208.
    1. Lougheed MD, Webb KA, O’Donnell DE. Breathlessness during induced hyperinflation in asthma: role of the inspiratory threshold load. Am J Respir Crit Care Med. 1995;152:911–20. doi: 10.1164/ajrccm.152.3.7663804.
    1. Henke KG, Regnis JA, Bye PTP. Benefits of continuous positive airway pressure during exercise in cystic fibrosis and relationship to disease severity. Am Rev Respir Dis. 1993;148:1272–6. doi: 10.1164/ajrccm/148.5.1272.
    1. Reis MS, Sampaio LM, Lacerda D, De Oliveira LV, Pereira GB, Pantoni CB, et al. Acute effects of different levels of contiuous positive airway pressure on cardiac autonomic modulation in chronic heart failure and chronic obstructive pulmonary disease. Arch Med Sci. 2010;6:719–27. doi: 10.5114/aoms.2010.17087.
    1. Reis HV, Borghi-Silva A, Catai AM, Reis MS. Impact of CPAP on physical exercise tolerance and sympathetic-vagal balance in patients with chronic heart failure. Braz J Phys Ther. 2014;18:218–27. doi: 10.1590/bjpt-rbf.2014.0037.
    1. Brochard L. Pressure support ventilation. In: Tobin MJ, editor. Principles and practice of mechanical ventilation. 2. New York: McGraw-Hill inc; 2006. pp. 221–50.
    1. Keilty SE, Ponte J, Fleming TA, Moxham J. Effect of inspiratory pressure support on exercise tolerance and breathlessness in patients with severe stable chronic obstructive pulmonary disease. Thorax. 1994;49:990–6. doi: 10.1136/thx.49.10.990.
    1. Wysocki M, Meshaka P, Richard JC, Similowsky T. Proportional-assist ventilation compared with pressure support ventilation during exercise in volunteers with external thoracic restriction. Crit Care Med. 2004;32:409–14. doi: 10.1097/01.CCM.0000108869.12426.51.
    1. Kyroussis D, Polkey MI, Keilty SE, Mills GH, Hamnegard CH, Moxham J, et al. Exhaustive exercise slows inspiratory muscle relaxation rate in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996;153:787–93. doi: 10.1164/ajrccm.153.2.8564133.
    1. Polkey MI, Kyroussis D, Mills GH, Hamnegard CH, Keilty SE, Green M, et al. Inspiratory pressure support reduces slowing of inspiratory muscle relaxation rate during exhaustive treadmill walking in severe COPD. Am J Respir Crit Care Med. 1996;154:1146–50. doi: 10.1164/ajrccm.154.4.8887619.
    1. Maltais F, Reissmann H, Gottfried SB. Pressure support reduces inspiratory effort and dyspnea during exercise in chronic airflow obstruction. Am J Respir Crit Care Med. 1995;151:1027–33.
    1. Kyroussis D, Polkey MI, Hamnegard CH, Mills GH, Green M, Moxham J. Respiratory muscle activity in patients with COPD walking to exhaustion with and without pressure support. Eur Respir J. 2000;15:649–55. doi: 10.1034/j.1399-3003.2000.15d05.x.
    1. van’t Hul A, Gosselink R, Hollander P, Postmus P, Kwakkel G. Acute effects of inspiratory pressure support during exercise in patients with COPD. Eur Respir J. 2004;23:34–40. doi: 10.1183/09031936.03.00016903.
    1. Polkey MI, Hawkins P, Kyroussis D, Ellum SG, Sherwood R, Moxham J. Inspiratory pressure support prolongs exercise induced lactataemia in severe COPD. Thorax. 2000;55:547–9. doi: 10.1136/thorax.55.7.547.
    1. Rodrigues MK, Oliveira MF, Soares A, Treptow E, Neder JA. Additive effects of non-invasive ventilation to hyperoxia on cerebral oxygenation in COPD patients with exercise-related O2 desaturation. Clin Physiol Funct Imaging. 2013;33:274–81. doi: 10.1111/cpf.12024.
    1. Lima CA, de Andrade AD, Campos SL, Brandão DC, Fregonezi G, Mourato IP, et al. Effects of noninvasive ventilation on treadmill 6-min walk distance and regional chest wall volumes in cystic fibrosis: Randomized controlled trial. Respir Med. 2014;108:1460–8. doi: 10.1016/j.rmed.2014.04.006.
    1. Vila B, Servera E, Marín J, Díaz J, Giménez M, Komaroff E, et al. Noninvasive ventilatory assistance during exercise for patients with kyphoscoliosis: a pilot study. Am J Phys Med Rehabil. 2007;86:672–7. doi: 10.1097/PHM.0b013e31806dd2c8.
    1. Borel JC, Wuyam B, Chouri-Pontarollo N, Deschaux C, Levy P, Pépin JL. During exercise non-invasive ventilation in chronic restrictive respiratory failure. Respir Med. 2008;102:711–9. doi: 10.1016/j.rmed.2007.12.017.
    1. Younes M. Proportional assist ventilation. In: Tobin MJ, editor. Principles and practice of mechanical ventilation. 2. New York: McGraw-Hill inc; 2006. pp. 335–64.
    1. Bianchi L, Foglio K, Pagani M, Vitacca M, Rossi A, Ambrosino N. Effects of proportional assist ventilation on exercise tolerance in COPD patients with chronic hypercapnia. Eur Respir J. 1998;11:422–7. doi: 10.1183/09031936.98.11020422.
    1. Dolmage TE, Goldstein RS. Proportional assist ventilation and exercise tolerance in subjects with COPD. Chest. 1997;111:948–54. doi: 10.1378/chest.111.4.948.
    1. Hernandez P, Maltais F, Gursahaney A, Leblanc P, Gottfried SB. Proportional assist ventilation may improve exercise performance in severe chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2001;21:135–42. doi: 10.1097/00008483-200105000-00003.
    1. Poggi R, Appendini L, Polese G, Colombo R, Donner CF, Rossi A. Noninvasive proportional assist ventilation and pressure support ventilation during arm elevation in patients with chronic respiratory failure. A preliminary, physiologic study. Respir Med. 2006;100:972–9. doi: 10.1016/j.rmed.2005.10.007.
    1. Carrascossa CR, Oliveira CC, Borghi-Silva A, Ferreira EM, Maya J, Queiroga F, Jr, et al. Haemodynamic effects of proportional assist ventilation during high intensity exercise in patients with chronic obstructive pulmonary disease. Respirology. 2010;15:1185–91. doi: 10.1111/j.1440-1843.2010.01846.x.
    1. Moderno EV, Yamaguti WP, Schettino GP, Kairalla RA, Martins MA, Carvalho CR, et al. Effects of proportional assisted ventilation on exercise performance in idiopathic pulmonary fibrosis patients. Respir Med. 2010;104:134–41. doi: 10.1016/j.rmed.2009.08.001.
    1. Dreher M, Kabitz HJ, Burgardt V, Walterspacher S, Windisch W. Proportional assist ventilation improves exercise capacity in patients with obesity. Respiration. 2010;80:106–11. doi: 10.1159/000245272.
    1. Mancebo J. Assist-control ventilation. In: Tobin MJ, editor. Principles and practice of mechanical ventilation. 2. New York: McGraw-Hill inc; 2006. pp. 183–200.
    1. Tsuboi T, Ohi M, Cjin K, Hirata H, Otsuka N, Kita H, et al. Ventilatory support during exercise in patients with pulmonary tuberculosis sequelae. Chest. 1997;112:1000–7. doi: 10.1378/chest.112.4.1000.
    1. Highcock MP, Smith IE, Shneerson JM. The effect of noninvasive intermittent positive-pressure ventilation during exercise in severe scoliosis. Chest. 2002;121:1555–60. doi: 10.1378/chest.121.5.1555.
    1. Make B. Pulmonary rehabilitation and lung volume reduction surgery. In: Donner CF, Ambrosino N, Goldstein RS, editors. Pulmonary Rehabilitation. London: Arnold Pub; 2005. pp. 297–303.
    1. Gay SE, Martinez FJ. Pulmonary rehabilitation and transplantation. In: Donner CF, Ambrosino N, Goldstein RS, editors. Pulmonary Rehabilitation. London: Arnold Pub; 2005. pp. 304–11.
    1. Bianchi L, Foglio K, Porta R, Baiardi R, Vitacca M, Ambrosino N. Lack of additional effect of adjunct of assisted ventilation to pulmonary rehabilitation in mild COPD patients. Respir Med. 2002;96:359–67. doi: 10.1053/rmed.2001.1287.
    1. Hawkins P, Johnson LC, Nikoletou D, Hamnegård CH, Sherwood R, Polkey MI, et al. Proportional assist ventilation as an aid to exercise training in severe chronic obstructive pulmonary disease. Thorax. 2002;57:853–9. doi: 10.1136/thorax.57.10.853.
    1. Márquez-Martín E, Ruiz FO, Ramos PC, López-Campos JL, Azcona BV, Cortés EB. Randomized trial of non-invasive ventilation combined with exercise training in patients with chronic hypercapnic failure due to chronic obstructive pulmonary disease. Respir Med. 2014;108:1741–51. doi: 10.1016/j.rmed.2014.10.005.
    1. Van t’Hul A, Gosselink R, Hollander P, Postmus P, Kwakkel G. Training with inspiratory pressure support in patients with severe COPD. Eur Respir J. 2006;27:65–72. doi: 10.1183/09031936.06.00036505.
    1. Johnson JE, Gavin DJ, Adams-Dramiga S. Effects of training with heliox and noninvasive positive pressure ventilation on exercise ability in patients with severe COPD. Chest. 2002;122:464–72. doi: 10.1378/chest.122.2.464.
    1. Costes F, Agresti A, Court-Fortune I, Roche F, Vergnon JM, Barthélémy JC. Noninvasive ventilation during exercise training improves exercise tolerance in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2003;23:307–13. doi: 10.1097/00008483-200307000-00008.
    1. Divo M, Cote C, de Torres JP, Casanova C, Marin JM, Pinto-Plata V, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186:155–61. doi: 10.1164/rccm.201201-0034OC.
    1. Ambrosino N. Assisted ventilation as an aid to exercise training: a mechanical doping? Eur Respir J. 2006;27:3–5. doi: 10.1183/09031936.06.00122805.
    1. Garrod R, Mikelsons C, Paul EA, Wedzicha JA. Randomized controlled trial of domiciliary non-invasive positive pressure ventilation and physical training in severe chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2000;162:1335–41. doi: 10.1164/ajrccm.162.4.9912029.
    1. Duiverman ML, Wempe JB, Bladder G, Jansen DF, Kerstjens HA, Zijlstra JG, et al. Nocturnal noninvasive ventilation in addition to rehabilitation in hypercapnic patients with COPD. Thorax. 2008;63:1052–7. doi: 10.1136/thx.2008.099044.
    1. Duiverman ML, Wempe JB, Bladder G, Vonk JM, Zijlstra JG, HAM Kerstjens HAM, et al. Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: A randomized controlled trial. Respir Res. 2011;12:112. doi: 10.1186/1465-9921-12-112.
    1. Dreher M, Storre JH, Windisch W. Noninvasive ventilation during walking in patients with severe COPD: a randomised cross-over trial. Eur Respir J. 2007;29:930–6. doi: 10.1183/09031936.00075806.
    1. Menadue C, Alison JA, Piper AJ, Flunt D, Ellis ER. Non-invasive ventilation during arm exercise and ground walking in patients with chronic hypercapnic respiratory failure. Respirology. 2009;14:251–9. doi: 10.1111/j.1440-1843.2008.01449.x.
    1. Menadue C, Alison JA, Piper AJ, Flunt D, Ellis ER. Bilevel ventilation during exercise in acute on chronic respiratory failure: a preliminary study. Respir Med. 2010;104:219–27. doi: 10.1016/j.rmed.2009.08.015.
    1. Dyer F, Flude L, Bazari F, Jolley C, Englebretsen C, Lai D, et al. Non-invasive ventilation (NIV) as an aid to rehabilitation in acute respiratory disease. BMC Pulm Med. 2011;11:58. doi: 10.1186/1471-2466-11-58.
    1. Borel JC, Verges S, Pepin JL, Vivodtzev I, Levy P, Wuyam B. Home exercise training with non-invasive ventilation in thoracic restrictive respiratory disorders: a randomised study. Respir Physiol Neurobiol. 2009;167:168–73. doi: 10.1016/j.resp.2009.03.014.
    1. Borghi-Silva A, Goncalves Mendes R, Toledo AC, Malosá Sampaio LM, da Silva TP, Kunikushita LN, et al. Adjuncts to physical training of patients with severe COPD: oxygen or noninvasive ventilation? Respir Care. 2010;55:885–94.
    1. Porszasz J, Cao R, Morishige R, van Eykern LA, Stenzler A, Casaburi R. Physiologic effects of an ambulatory ventilation system in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;188:334–42. doi: 10.1164/rccm.201210-1773OC.
    1. Ricci C, Terzoni S, Gaeta M, Sorgente A, Destrebecq A, Gigliotti F. Physical training and noninvasive ventilation in COPD patients: a meta-analysis. Respir Care. 2014;59:709–17. doi: 10.4187/respcare.02626.
    1. Menadue C, Piper AJ, van’t Hul AJ, Wong KK. Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;5:CD007714.

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