Dysmenorrhea and related disorders

Mariagiulia Bernardi, Lucia Lazzeri, Federica Perelli, Fernando M Reis, Felice Petraglia, Mariagiulia Bernardi, Lucia Lazzeri, Federica Perelli, Fernando M Reis, Felice Petraglia

Abstract

Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. The secondary forms of dysmenorrhea are associated with endometriosis and adenomyosis and may represent the key symptom. The diagnosis is suspected on the basis of the clinical history and the physical examination and can be confirmed by ultrasound, which is very useful to exclude some secondary causes of dysmenorrhea, such as endometriosis and adenomyosis. The treatment options include non-steroidal anti-inflammatory drugs alone or combined with oral contraceptives or progestins.

Keywords: Dysmenorrhea; adenomyosis; endometriosis; menstrual disorders.

Conflict of interest statement

Competing interests: The authors declare that they have no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

Figures

Figure 1.. Flowchart for the management of…
Figure 1.. Flowchart for the management of patients with dysmenorrhea.
Flowchart for the management of patients with dysmenorrhea.

References

    1. Hanoch Kumar K, Elavarasi P: Definition of pain and classification of pain disorders. Journal of Advanced Clinical & Research Insight. 2016;3:87–90. 10.15713/ins.jcri.112
    1. ACOG Committee on Practice Bulletins--Gynecology: ACOG Practice Bulletin No. 51. Chronic pelvic pain. Obstet Gynecol. 2004;103(3):589–605.
    1. Patel V, Tanksale V, Sahasrabhojanee M, et al. : The burden and determinants of dysmenorrhoea: a population-based survey of 2262 women in Goa, India. BJOG. 2006;113(4):453–63. 10.1111/j.1471-0528.2006.00874.x
    1. Harlow SD, Campbell OM: Epidemiology of menstrual disorders in developing countries: a systematic review. BJOG. 2004;111(1):6–16. 10.1111/j.1471-0528.2004.00012.x
    1. Weissman AM, Hartz AJ, Hansen MD, et al. : The natural history of primary dysmenorrhoea: a longitudinal study. BJOG. 2004;111(4):345–52. 10.1111/j.1471-0528.2004.00090.x
    1. Wong LP, Khoo EM: Dysmenorrhea in a multiethnic population of adolescent Asian girls. Int J Gynaecol Obstet. 2010;108(2):139–42. 10.1016/j.ijgo.2009.09.018
    1. De Sanctis V, Soliman A, Bernasconi S, et al. : Primary Dysmenorrhea in Adolescents: Prevalence, Impact and Recent Knowledge. Pediatr Endocrinol Rev. 2015;13(2):512–20.
    1. Thomas SL, Ellertson C: Nuisance or natural and healthy: should monthly menstruation be optional for women? Lancet. 2000;355(9207):922–4. 10.1016/S0140-6736(99)11159-0
    1. Eryilmaz G, Ozdemir F, Pasinlioglu T: Dysmenorrhea prevalence among adolescents in eastern Turkey: its effects on school performance and relationships with family and friends. J Pediatr Adolesc Gynecol. 2010;23(5):267–72. 10.1016/j.jpag.2010.02.009
    1. Latthe P, Latthe M, Say L, et al. : WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity. BMC Public Health. 2006;6:177. 10.1186/1471-2458-6-177
    1. Parker MA, Sneddon AE, Arbon P: The menstrual disorder of teenagers (MDOT) study: determining typical menstrual patterns and menstrual disturbance in a large population-based study of Australian teenagers. BJOG. 2010;117(2):185–92. 10.1111/j.1471-0528.2009.02407.x
    1. Lindh I, Ellström AA, Milsom I: The effect of combined oral contraceptives and age on dysmenorrhoea: an epidemiological study. Hum Reprod. 2012;27(3):676–82. 10.1093/humrep/der417
    1. Wong CL, Farquhar C, Roberts H, et al. : Oral contraceptive pill for primary dysmenorrhoea. Cochrane Database Syst Rev. 2009; (4):CD002120. 10.1002/14651858.CD002120.pub3
    1. Subasinghe AK, Happo L, Jayasinghe YL, et al. : Prevalence and severity of dysmenorrhoea, and management options reported by young Australian women. Aust Fam Physician. 2016;45(11):829–34.
    1. Zannoni L, Giorgi M, Spagnolo E, et al. : Dysmenorrhea, absenteeism from school, and symptoms suspicious for endometriosis in adolescents. J Pediatr Adolesc Gynecol. 2014;27(5):258–65. 10.1016/j.jpag.2013.11.008
    1. Ortiz MI, Rangel-Flores E, Carrillo-Alarcón LC, et al. : Prevalence and impact of primary dysmenorrhea among Mexican high school students. Int J Gynaecol Obstet. 2009;107(3):240–3. 10.1016/j.ijgo.2009.07.031
    1. Chantler I, Mitchell D, Fuller A: Actigraphy quantifies reduced voluntary physical activity in women with primary dysmenorrhea. J Pain. 2009;10(1):38–46. 10.1016/j.jpain.2008.07.002
    1. Banikarim C, Chacko MR, Kelder SH: Prevalence and impact of dysmenorrhea on Hispanic female adolescents. Arch Pediatr Adolesc Med. 2000;154(12):1226–9. 10.1001/archpedi.154.12.1226
    1. Hailemeskel S, Demissie A, Assefa N: Primary dysmenorrhea magnitude, associated risk factors, and its effect on academic performance: evidence from female university students in Ethiopia. Int J Womens Health. 2016;8:489–96. 10.2147/IJWH.S112768
    2. F1000 Recommendation

    1. Unsal A, Ayranci U, Tozun M, et al. : Prevalence of dysmenorrhea and its effect on quality of life among a group of female university students. Ups J Med Sci. 2010;115(2):138–45. 10.3109/03009730903457218
    1. Baker FC, Driver HS, Rogers GG, et al. : High nocturnal body temperatures and disturbed sleep in women with primary dysmenorrhea. Am J Physiol. 1999;277(6 Pt 1):E1013–21.
    1. Dorn LD, Negriff S, Huang B, et al. : Menstrual symptoms in adolescent girls: association with smoking, depressive symptoms, and anxiety. J Adolesc Health. 2009;44(3):237–43. 10.1016/j.jadohealth.2008.07.018
    1. Proctor M, Farquhar C: Diagnosis and management of dysmenorrhoea. BMJ. 2006;332(7550):1134–8. 10.1136/bmj.332.7550.1134
    1. Iacovides S, Avidon I, Baker FC: What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015;21(6):762–78. 10.1093/humupd/dmv039
    1. Dawood MY: Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol. 2006;108(2):428–41. 10.1097/01.AOG.0000230214.26638.0c
    1. Lefebvre G, Pinsonneault O, Antao V, et al. : Primary dysmenorrhea consensus guideline. J Obstet Gynaecol Can. 2005;27(12):1117–46. 10.1016/S1701-2163(16)30395-4
    1. Brawn J, Morotti M, Zondervan KT, et al. : Central changes associated with chronic pelvic pain and endometriosis. Hum Reprod Update. 2014;20(5):737–47. 10.1093/humupd/dmu025
    1. Bulun SE: Endometriosis. N Engl J Med. 2009;360(3):268–79. 10.1056/NEJMra0804690
    1. Morotti M, Vincent K, Brawn J, et al. : Peripheral changes in endometriosis-associated pain. Hum Reprod Update. 2014;20(5):717–36. 10.1093/humupd/dmu021
    1. Arruda MS, Petta CA, Abrão MS, et al. : Time elapsed from onset of symptoms to diagnosis of endometriosis in a cohort study of Brazilian women. Hum Reprod. 2003;18(4):756–9. 10.1093/humrep/deg136
    1. Chapron C, Borghese B, Streuli I, et al. : Markers of adult endometriosis detectable in adolescence. J Pediatr Adolesc Gynecol. 2011;24(5 Suppl):S7–12. 10.1016/j.jpag.2011.07.006
    1. Treloar SA, Bell TA, Nagle CM, et al. : Early menstrual characteristics associated with subsequent diagnosis of endometriosis. Am J Obstet Gynecol. 2010;202(6):534.e1–6. 10.1016/j.ajog.2009.10.857
    1. Chapron C, Lafay-Pillet MC, Monceau E, et al. : Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis. Fertil Steril. 2011;95(3):877–81. 10.1016/j.fertnstert.2010.10.027
    1. Crosignani P, Olive D, Bergqvist A, et al. : Advances in the management of endometriosis: an update for clinicians. Hum Reprod Update. 2006;12(2):179–89. 10.1093/humupd/dmi049
    1. Janssen EB, Rijkers AC, Hoppenbrouwers K, et al. : Prevalence of endometriosis diagnosed by laparoscopy in adolescents with dysmenorrhea or chronic pelvic pain: a systematic review. Hum Reprod Update. 2013;19(5):570–82. 10.1093/humupd/dmt016
    2. F1000 Recommendation

    1. Munro MG, Critchley HO, Broder MS, et al. : FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet. 2011;113(1):3–13. 10.1016/j.ijgo.2010.11.011
    1. van den Bosch T, Dueholm M, Leone FP, et al. : Terms, definitions and measurements to describe sonographic features of myometrium and uterine masses: a consensus opinion from the Morphological Uterus Sonographic Assessment (MUSA) group. Ultrasound Obstet Gynecol. 2015;46(3):284–98. 10.1002/uog.14806
    1. Naftalin J, Hoo W, Nunes N, et al. : Association between ultrasound features of adenomyosis and severity of menstrual pain. Ultrasound Obstet Gynecol. 2016;47(6):779–83. 10.1002/uog.15798
    2. F1000 Recommendation

    1. Pinzauti S, Lazzeri L, Tosti C, et al. : Transvaginal sonographic features of diffuse adenomyosis in 18–30-year-old nulligravid women without endometriosis: association with symptoms. Ultrasound Obstet Gynecol. 2015;46(6):730–6. 10.1002/uog.14834
    1. Eryilmaz G, Ozdemir F, Pasinlioglu T: Dysmenorrhea prevalence among adolescents in eastern Turkey: its effects on school performance and relationships with family and friends. J Pediatr Adolesc Gynecol. 2010;23(5):267–72. 10.1016/j.jpag.2010.02.009
    1. Zahradnik HP, Hanjalic-Beck A, Groth K: Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review. Contraception. 2010;81(3):185–96. 10.1016/j.contraception.2009.09.014
    1. Harel Z: Dysmenorrhea in adolescents and young adults: an update on pharmacological treatments and management strategies. Expert Opin Pharmacother. 2012;13(15):2157–70. 10.1517/14656566.2012.725045
    1. Marjoribanks J, Ayeleke RO, Farquhar C, et al. : Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2015; (7):CD001751. 10.1002/14651858.CD001751.pub3
    2. F1000 Recommendation

    1. American College of Obstetricians and Gynecologists: ACOG Committee Opinion. Number 310, April 2005. Endometriosis in adolescents. Obstet Gynecol. 2005;105(4):921–7.
    1. ESHRE Capri Workshop Group: Noncontraceptive health benefits of combined oral contraception. Hum Reprod Update. 2005;11(5):513–25. 10.1093/humupd/dmi019
    1. Dunselman GA, Vermeulen N, Becker C, et al. : ESHRE guideline: management of women with endometriosis. Hum Reprod. 2014;29(3):400–12. 10.1093/humrep/det457
    2. F1000 Recommendation

    1. Brill K, Norpoth T, Schnitker J, et al. : Clinical experience with a modern low-dose oral contraceptive in almost 100,000 users. Contraception. 1991;43(2):101–10. 10.1016/0010-7824(91)90037-G
    1. Harada T, Momoeda M, Taketani Y, et al. : Low-dose oral contraceptive pill for dysmenorrhea associated with endometriosis: a placebo-controlled, double-blind, randomized trial. Fertil Steril. 2008;90(5):1583–8. 10.1016/j.fertnstert.2007.08.051
    2. F1000 Recommendation

    1. Harada T, Momoeda M, Terakawa N, et al. : Evaluation of a low-dose oral contraceptive pill for primary dysmenorrhea: a placebo-controlled, double-blind, randomized trial. Fertil Steril. 2011;95(6):1928–31. 10.1016/j.fertnstert.2011.02.045
    1. Harada T, Momoeda M: Evaluation of an ultra-low-dose oral contraceptive for dysmenorrhea: a placebo-controlled, double-blind, randomized trial. Fertil Steril. 2016;106(7):1807–14. 10.1016/j.fertnstert.2016.08.051
    1. Priya K, Rajaram S, Goel N: Comparison of combined hormonal vaginal ring and low dose combined oral hormonal pill for the treatment of idiopathic chronic pelvic pain: a randomised trial. Eur J Obstet Gynecol Reprod Biol. 2016;207:141–6. 10.1016/j.ejogrb.2016.10.026
    1. Vercellini P, Buggio L, Berlanda N, et al. : Estrogen-progestins and progestins for the management of endometriosis. Fertil Steril. 2016;106(7):1552–1571.e2. 10.1016/j.fertnstert.2016.10.022
    1. Ryan SA: The Treatment of Dysmenorrhea. Pediatr Clin North Am. 2017;64(2):331–42. 10.1016/j.pcl.2016.11.004

Source: PubMed

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