Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohort

Inmaculada Aguilera, Mònica Guxens, Raquel Garcia-Esteban, Teresa Corbella, Mark J Nieuwenhuijsen, Carles M Foradada, Jordi Sunyer, Inmaculada Aguilera, Mònica Guxens, Raquel Garcia-Esteban, Teresa Corbella, Mark J Nieuwenhuijsen, Carles M Foradada, Jordi Sunyer

Abstract

Background: There is growing evidence that traffic-related air pollution reduces birth weight. Improving exposure assessment is a key issue to advance in this research area.

Objective: We investigated the effect of prenatal exposure to traffic-related air pollution via geographic information system (GIS) models on birth weight in 570 newborns from the INMA (Environment and Childhood) Sabadell cohort.

Methods: We estimated pregnancy and trimester-specific exposures to nitrogen dioxide and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] by using temporally adjusted land-use regression (LUR) models. We built models for NO(2) and BTEX using four and three 1-week measurement campaigns, respectively, at 57 locations. We assessed the relationship between prenatal air pollution exposure and birth weight with linear regression models. We performed sensitivity analyses considering time spent at home and time spent in nonresidential outdoor environments during pregnancy.

Results: In the overall cohort, neither NO(2) nor BTEX exposure was significantly associated with birth weight in any of the exposure periods. When considering only women who spent < 2 hr/day in nonresidential outdoor environments, the estimated reductions in birth weight associated with an interquartile range increase in BTEX exposure levels were 77 g [95% confidence interval (CI), 7-146 g] and 102 g (95% CI, 28-176 g) for exposures during the whole pregnancy and the second trimester, respectively. The effects of NO(2) exposure were less clear in this subset.

Conclusions: The association of BTEX with reduced birth weight underscores the negative role of vehicle exhaust pollutants in reproductive health. Time-activity patterns during pregnancy complement GIS-based models in exposure assessment.

Keywords: INMA study; air pollution; aromatic hydrocarbons; birth weight; cohort study; exposure assessment; geographic information system; nitrogen dioxide; pregnancy.

References

    1. Agency for Toxic Substances and Disease Registry. Interaction Profile for Benzene, Toluene, Ethylbenzene, and Xylenes (BTEX) Atlanta, GA: Agency for Toxic Substances and Disease Registry; 2004. [[accessed 10 September 2008]]. Available: .
    1. Aguilera I, Sunyer J, Fernández-Patier R, Hoek G, Aguirre-Alfaro A, Meliefste K, et al. Estimation of outdoor NOx, NO2, and BTEX exposure in a cohort of pregnant women using land use regression modeling. Environ Sci Technol. 2008;42:815–821.
    1. Alexopoulos EC, Chatzis C, Linos A. An analysis of factors that influence personal exposure to toluene and xylene in residents of Athens, Greece. BMC Public Health. 2006;6:50. doi: 10.1186/1471-2458-6-50. [Online 28 February 2006]
    1. Bell ML, Ebisu K, Belanger K. Ambient air pollution and low birth weight in Connecticut and Massachusetts. Environ Health Perspect. 2007;115:1118–1124.
    1. Blair EM, Liu Y, de Klerk NH, Lawrence DM. Optimal fetal growth for the Caucasian singleton and assessment of appropriateness of fetal growth: an analysis of a total population perinatal database. BMC Pediatr. 2005;5:13. doi: 10.1186/1471-2431-5-13. [Online 24 May 2005]
    1. Brauer M, Lencar C, Tamburic L, Koehoorn M, Demers P, Karr C. A cohort study of traffic-related air pollution impacts on birth outcomes. Environ Health Perspect. 2008;116:680–686.
    1. European Commission. Council Directive 1999/30/EC of 22 April 1999 Relating to Limit Values for Sulphur Dioxide, Nitrogen Dioxide and Oxides of Nitrogen, Particulate Matter and Lead in Ambient Air. [[accessed 15 September 2008]];1999 Available: .
    1. Fell DB, Dodds L, King WD. Residential mobility during pregnancy. Paediatr Perinat Epidemiol. 2004;18:408–414.
    1. Forastiere F, Stafoggia M, Tasco C, Picciotto S, Agabiti N, Cesaroni G, et al. Socioeconomic status, particulate air pollution, and daily mortality: differential exposure or differential susceptibility. Am J Ind Med. 2007;50:208–216.
    1. Gilliland F, Avol E, Kinney P, Jerrett M, Dvonch T, Lurmann F, et al. Air pollution exposure assessment for epidemiologic studies of pregnant women and children: lessons learned from the Centers for Children’s Environmental Health and Disease Prevention Research. Environ Health Perspect. 2005;113:1447–1454.
    1. Glinianaia SV, Rankin J, Bell R, Pless-Mulloli T, Howel D. Particulate air pollution and fetal health: a systematic review of the epidemiologic evidence. Epidemiology. 2004;15:36–45.
    1. Gouveia N, Bremner SA, Novaes HM. Association between ambient air pollution and birth weight in São Paulo, Brazil. J Epidemiol Community Health. 2004;58:11–17.
    1. Ha EH, Hong YC, Lee BE, Woo BH, Schwartz J, Christiani DC. Is air pollution a risk factor for low birth weight in Seoul? Epidemiology. 2001;12:643–648.
    1. Hansen C, Neller A, Williams G, Simpson R. Low levels of ambient air pollution during pregnancy and fetal growth among term neonates in Brisbane, Australia. Environ Res. 2007;103:383–389.
    1. Hazenkamp-von Arx ME, Götschi T, Ackermann-Liebrich U, Bono R, Burney P, Cyrys J, et al. PM2.5 and NO2 assessment in 21 European study centres of ECRHS II: annual means and seasonal differences. Atmos Environ. 2004;38:1943–1953.
    1. Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA. Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet. 2002;360:1203–1209.
    1. Jedrychowski W, Bendkowska I, Flak E, Penar A, Jacek R, Kaim I, et al. Estimated risk for altered fetal growth resulting from exposure to fine particles during pregnancy: an epidemiologic prospective cohort study in Poland. Environ Health Perspect. 2004;112:1398–1402.
    1. Kannan S, Misra DP, Dvonch JT, Krishnakumar A. Exposures to airborne particulate matter and adverse perinatal outcomes: a biologically plausible mechanistic framework for exploring potential effect modification by nutrition. Environ Health Perspect. 2006;114:1636–1642.
    1. Lacasaña M, Esplugues A, Ballester F. Exposure to ambient air pollution and prenatal and early childhood health effects. Eur J Epidemiol. 2005;20:183–199.
    1. Lebret E, Briggs D, Van Reeuwijk H, Fischer P, Smallbone K, Harssema H, et al. Small area variations in ambient NO2 concentrations in four European areas. Atmos Environ. 2000;34:177–185.
    1. Lee BE, Ha EH, Park HS, Kim YJ, Hong YC, Kim H, et al. Exposure to air pollution during different gestational phases contributes to risks of low birth weight. Hum Reprod. 2003;18:638–643.
    1. Liu S, Krewski D, Shi Y, Chen Y, Burnett RT. Association between gaseous ambient air pollutants and adverse pregnancy outcomes in Vancouver, Canada. Environ Health Perspect. 2003;111:1773–1778.
    1. Liu S, Krewski D, Shi Y, Chen Y, Burnett RT. Association between maternal exposure to ambient air pollutants during pregnancy and fetal growth restriction. J Expo Sci Environ Epidemiol. 2007;17:426–432.
    1. Mannes T, Jalaludin B, Morgan G, Lincoln D, Sheppeard V, Corbett S. Impact of ambient air pollution on birth weight in Sydney, Australia. Occup Environ Med. 2005;62:524–530.
    1. Muñoz F. Lock living: urban sprawl in Mediterranean cities. Cities. 2003;20:381–385.
    1. Murray LJ, O’Reilly DP, Betts N, Patterson CC, Davey SG, Evans AE. Season and outdoor ambient temperature: effects on birth weight. Obstet Gynecol. 2000;96:689–695.
    1. Nethery E, Brauer M, Janssen P. Time-activity patterns of pregnant women and changes during the course of pregnancy. J Expo Sci Environ Epidemiol. 2009;19:317–324.
    1. Nethery E, Leckie SE, Teschke K, Brauer M. From measures to models: an evaluation of air pollution exposure assessment for epidemiologic studies of pregnant women. Occup Environ Med. 2008;65:579–586.
    1. O’Neill MS, Jerrett M, Kawachi I, Levy JI, Cohen AJ, Gouveia N, et al. Health, wealth, and air pollution: advancing theory and methods. Environ Health Perspect. 2003;111:1861–1870.
    1. Ribas-Fitó N, Ramón R, Ballester F, Grimalt J, Marco A, Olea N, et al. Child health and the environment: the INMA Spanish Study. Paediatr Perinat Epidemiol. 2006;20:403–410.
    1. Ritz B, Wilhelm M. Ambient air pollution and adverse birth outcomes: methodologic issues in an emerging field. Basic Clin Pharmacol Toxicol. 2008;102:182–190.
    1. Rivas-Lara I. Variabilitat temporal i geogràfica i caracterització química de la contaminació atmosfèrica particulada a Sabadell [in Catalan] [MSc thesis] Barcelona, Spain: Autonomous University of Barcelona; 2008. [[accessed 15 December 2008]]. Available: .
    1. Salam MT, Millstein J, Li YF, Lurmann FW, Margolis HG, Gilliland FD. Birth outcomes and prenatal exposure to ozone, carbon monoxide, and particulate matter: results from the Children’s Health Study. Environ Health Perspect. 2005;113:1638–1644.
    1. Sinclair KD, Lea RG, Rees WD, Young LE. The developmental origins of health and disease: current theories and epigenetic mechanisms. Soc Reprod Fertil. 2007;64(suppl):425–443.
    1. Slama R, Darrow L, Parker J, Woodruff TJ, Strickland M, Nieuwenhuijsen M, et al. Meeting report: atmospheric pollution and human reproduction. Environ Health Perspect. 2008a;116:791–798.
    1. Slama R, Khoshnood B, Kaminski M. How to control for gestational age in studies involving environmental effects on fetal growth [Letter] Environ Health Perspect. 2008b;116:A284.
    1. Slama R, Morgenstern V, Cyrys J, Zutavern A, Herbarth O, Wichmann HE, et al. Traffic-related atmospheric pollutants levels during pregnancy and offspring’s term birth weight: a study relying on a land-use regression exposure model. Environ Health Perspect. 2007;115:1283–1292.
    1. Šrám RJ, Binková B, Dejmek J, Bobak M. Ambient air pollution and pregnancy outcomes: a review of the literature. Environ Health Perspect. 2005;113:375–382.
    1. Tustin K, Gross J, Hayne H. Maternal exposure to first-trimester sunshine is associated with increased birth weight in human infants. Dev Psychobiol. 2004;45:221–230.
    1. Wang L, Pinkerton KE. Air pollutant effects on fetal and early postnatal development. Birth Defects Res C Embryo Today. 2007;81:144–154.
    1. Westerway SC, Davison A, Cowell S. Ultrasonic fetal measurements: new Australian standards for the new millennium. Aust N Z J Obstet Gynaecol. 2000;40:297–302.
    1. Wilhelm M, Ritz B. Local variations in CO and particulate air pollution and adverse birth outcomes in Los Angeles County, California, USA. Environ Health Perspect. 2005;113:1212–1221.

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