Nausea and vomiting of pregnancy: associations with personal history of nausea and affected relatives

Linda Laitinen, Miina Nurmi, Pauliina Ellilä, Päivi Rautava, Mari Koivisto, Päivi Polo-Kantola, Linda Laitinen, Miina Nurmi, Pauliina Ellilä, Päivi Rautava, Mari Koivisto, Päivi Polo-Kantola

Abstract

Purpose: To examine whether personal history of nausea or history of nausea and vomiting of pregnancy (NVP) in relatives are risk factors for a woman to suffer from NVP. Further, to evaluate if these factors are associated with the severity of NVP.

Methods: Cohort study of 2411 pregnant women recruited from maternity health care clinics. The severity of NVP was categorized according to Pregnancy-Unique Quantification of Emesis (PUQE) questionnaire into no/mild/moderate/severe NVP. History of nausea was assessed in connection with motion sickness, seasickness, migraine or other kinds of headache, after anesthesia, related to the use of contraceptives, and other kinds of nausea. History of NVP in relatives was categorized into first-degree (mother/sister) and second-degree relatives (more distant).

Results: In multivariable analysis including previous personal history of nausea, motion sickness (OR 3.17, 95% CI 1.81-5.56, p < 0.0001) and nausea in migraine (OR 3.18, 95% CI 1.86-5.45, p < 0.0001) were associated with severe NVP. History of nausea in other kinds of headache was associated with moderate NVP (OR 1.91, 95% CI 1.34-2.72, p = 0.001). Women with affected first-degree relatives had higher odds for moderate (OR 3.84, 95% CI 2.72-5.40) and severe (OR 3.19, 95% CI 1.92-5.28) NVP (p < 0.0001). All these results remained significant after adjusting for parity, body mass index, smoking, employment and age.

Conclusion: Women with personal history of nausea or family history of NVP have an increased susceptibility of NVP. This information is useful in pre-pregnancy counselling.

Keywords: Migraine; Nausea and vomiting of pregnancy; PUQE; Pregnancy; Relatives.

Conflict of interest statement

All authors disclose no conflicts of interest pertaining to this manuscript.

Figures

Fig.1
Fig.1
Flowchart of the study

References

    1. Lee NM, Saha S. Nausea and vomiting of pregnancy. Gastroenterol Clin North Am. 2011;40(2):309–334. doi: 10.1016/j.gtc.2011.03.009.
    1. London V, Grube S, Sherer DM, Abulafia O. Hyperemesis gravidarum: a review of recent literature. Pharmacology. 2017;100(3–4):161–171. doi: 10.1159/000477853.
    1. Wood H, McKellar LV, Lightbody M. Nausea and vomiting in pregnancy: blooming or bloomin’ awful? A review of the literature. Women and Birth. 2013;26(2):100–104. doi: 10.1016/j.wombi.2012.10.001.
    1. Balaban CD, Yates BJ. What is nausea? a historical analysis of changing views. Auton Neurosci. 2017;202:5–17. doi: 10.1016/j.autneu.2016.07.003.
    1. Goodwin TM. Nausea and vomiting of pregnancy: An obstetric syndrome. Am J Obstet Gynecol. 2002;186:S184–S189. doi: 10.1067/mob.2002.122592.
    1. Fejzo MS, Trovik J, Grooten IJ, Sridharan K, Roseboom TJ, Vikanes Å, Painter RC, Mullin PM. Nausea and vomiting of pregnancy and hyperemesis gravidarum. Nat Rev Dis Primers. 2019;125(1):62. doi: 10.1038/s41572-019-0110-3.
    1. Golding JF, Gresty MA. Pathophysiology and treatment of motion sickness. Curr Opin Neurol. 2015;28(1):83–88. doi: 10.1097/WCO.0000000000000163.
    1. Bertolini G, Straumann D. Moving in a moving world: a review on vestibular motion sickness. Front Neurol. 2016;7:14. doi: 10.3389/fneur.2016.00014.
    1. Heinrichs L. Linking olfaction with nausea and vomiting of pregnancy, recurrent abortion, hyperemesis gravidarum, and migraine headache. Am J Obstet Gynecol. 2002;186:S215. doi: 10.1067/mob.2002.123053.
    1. Buse DC, Loder EW, Gorman JA, Stewart WF, Reed ML, Fanning KM, et al. Sex differences in the prevalence, symptoms, and associated features of migraine, probable migraine and other severe headache: results of the American migraine prevalence and prevention (AMPP) study. Headache. 2013;53(8):1278–1299. doi: 10.1111/head.12150.
    1. Moreau C, Trussell J, Gilbert F, Bajos N, Bouyer J. Oral contraceptive tolerance: does the type of pill matter? Obs Gynecol. 2007;109(6):1277–1285. doi: 10.1097/01.AOG.0000260956.61835.6d.
    1. Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Eur J Pharmacol. 2014;722:55–66. doi: 10.1016/j.ejphar.2013.10.037.
    1. Zhang Y, Cantor RM, Macgibbon K, Romero R, Goodwin TM, Mullin PM, et al. Familial aggregation of hyperemesis gravidarum. Am J Obstet Gynecol. 2011;204(3):230.e1–7. doi: 10.1016/j.ajog.2010.09.018.
    1. Vikanes A, Skjaerven R, Grjibovski AM, Gunnes N, Vangen S, Magnus P. Recurrence of hyperemesis gravidarum across generations: population based cohort study. BMJ. 2010;340:c2050.
    1. Fejzo MS, Ingles SA, Wilson M, Wang W, MacGibbon K, Romero R, et al. High prevalence of severe nausea and vomiting of pregnancy and hyperemesis gravidarum among relatives of affected individuals. Eur J Obstet Gynecol Reprod Biol. 2008;141(1):13–17. doi: 10.1016/j.ejogrb.2008.07.003.
    1. Colodro-Conde L, Jern P, Johansson A, Sánchez-Romera JF, Lind PA, Painter JN, et al. Nausea and vomiting during pregnancy is highly heritable. Behav Genet. 2016;46(4):481–491. doi: 10.1007/s10519-016-9781-7.
    1. Fejzo MS, Sazonova OV, Sathirapongsasuti JF, Hallgrímsdóttir IB, Vacic V, MacGibbon KW, et al. Placenta and appetite genes GDF15 and IGFBP7 are associated with hyperemesis gravidarum. Nat Commun. 2018;9(1):1178. doi: 10.1038/s41467-018-03258-0.
    1. Koren G, Piwko C, Ahn E, Boskovic R, Maltepe C, Einarson A, et al. Validation studies of the pregnancy unique-quantification of emesis (PUQE) scores. J Obstet Gynaecol. 2005;25(3):241–244. doi: 10.1080/01443610500060651.
    1. Gissler M. Perinatal statistics: parturients, deliveries and newborns 2014–2015. Finnish National Institute for Health and Welfare. Available at: . Accessed 15 Oct 2019
    1. Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014;118(1):85–113. doi: 10.1213/ANE.0000000000000002.
    1. Martin VT, Behbehani M. Ovarian Hormones and Migraine headache: understanding Mechanisms and pathogenesis-Part 2. Headache J Head Face Pain. 2006;46(3):365–386. doi: 10.1111/j.1526-4610.2006.00370.x.
    1. Rosenberg MJ, Meyers A, Roy V. Efficacy, cycle control, and side effects of low- and lower-dose oral contraceptives: a randomized trial of 20 micrograms and 35 micrograms estrogen preparations. Contraception. 1999;60(6):321–329. doi: 10.1016/S0010-7824(99)00109-2.
    1. Goodwin TM. Hyperemesis gravidarum. Obstet Gynecol Clin North Am. 2008;35(3):401–417. doi: 10.1016/j.ogc.2008.04.002.
    1. Järnfelt-Samsioe A, Eriksson B, Waldenström J, Samsioe G. Some new aspects on emesis gravidarum: relations to clinical data, serum electrolytes, total protein and creatinine. Gynecol Obstet Invest. 1985;19(4):174–186. doi: 10.1159/000299031.
    1. Whitehead S, Andrews P, Chamberlain G. Characterisation of nausea and vomiting in early pregnancy: a survey of 1000 women. J Obstet Gynecol. 1992;12(6):364–369. doi: 10.3109/01443619209025932.
    1. Gadsby R, Barnie-Adshead A, Jagger C. Pregnancy nausea related to women’s obstetric and personal histories. Gynecol Obstet Invest. 1997;43(2):108–111. doi: 10.1159/000291833.
    1. Goodwin TM, Nwankwo OA, O’Leary LD, O’Leary D, Romero R, Korst LM. The first demonstration that a subset of women with hyperemesis gravidarum has abnormalities in the vestibuloocular reflex pathway. Am J Obstet Gynecol. 2008;199(4):417.e1–9. doi: 10.1016/j.ajog.2008.07.003.
    1. Black FO. Maternal susceptibility to nausea and vomiting of pregnancy: Is the vestibular system involved? Am J Obstet Gynecol. 2002;186:S204–S209. doi: 10.1067/mob.2002.122602.
    1. Peterlin BL, Gupta S, Ward TN, MacGregor A. Sex matters: evaluating sex and gender in migraine and headache research. Headache. 2011;51(6):839–842. doi: 10.1111/j.1526-4610.2011.01900.x.
    1. Einarson TR, Navioz Y, Maltepe C, Einarson A, Koren G. Existence and severity of nausea and vomiting in pregnancy (NVP) with different partners. J Obstet Gynaecol. 2007;27(4):360–362. doi: 10.1080/01443610701327362.
    1. Trogstad LIS, Stoltenberg C, Magnus P, Skjaerven R, Irgens LM. Recurrence risk in hyperemesis gravidarum. BJOG An Int J Obstet Gynaecol. 2005;112(12):1641–1645. doi: 10.1111/j.1471-0528.2005.00765.x.

Source: PubMed

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

3
Abonner