Curcumin: A Review of Its Effects on Human Health

Susan J Hewlings, Douglas S Kalman, Susan J Hewlings, Douglas S Kalman

Abstract

Turmeric, a spice that has long been recognized for its medicinal properties, has received interest from both the medical/scientific world and from culinary enthusiasts, as it is the major source of the polyphenol curcumin. It aids in the management of oxidative and inflammatory conditions, metabolic syndrome, arthritis, anxiety, and hyperlipidemia. It may also help in the management of exercise-induced inflammation and muscle soreness, thus enhancing recovery and performance in active people. In addition, a relatively low dose of the complex can provide health benefits for people that do not have diagnosed health conditions. Most of these benefits can be attributed to its antioxidant and anti-inflammatory effects. Ingesting curcumin by itself does not lead to the associated health benefits due to its poor bioavailability, which appears to be primarily due to poor absorption, rapid metabolism, and rapid elimination. There are several components that can increase bioavailability. For example, piperine is the major active component of black pepper and, when combined in a complex with curcumin, has been shown to increase bioavailability by 2000%. Curcumin combined with enhancing agents provides multiple health benefits. The purpose of this review is to provide a brief overview of the plethora of research regarding the health benefits of curcumin.

Keywords: anti-inflammatory; antioxidant; curcumin; polyphenol; turmeric.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Priyadarsini K.I. The chemistry of curcumin: From extraction to therapeutic agent. Molecules. 2014;19:20091–20112. doi: 10.3390/molecules191220091.
    1. Gupta S.C., Patchva S., Aggarwal B.B. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J. 2013;15:195–218. doi: 10.1208/s12248-012-9432-8.
    1. Aggarwal B.B., Kumar A., Bharti A.C. Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res. 2003;23:363–398.
    1. Lestari M.L., Indrayanto G. Curcumin. Profiles Drug Subst. Excip. Relat. Methodol. 2014;39:113–204.
    1. Mahady G.B., Pendland S.L., Yun G., Lu Z.Z. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res. 2002;22:4179–4181.
    1. Reddy R.C., Vatsala P.G., Keshamouni V.G., Padmanaban G., Rangarajan P.N. Curcumin for malaria therapy. Biochem. Biophys. Res. Commun. 2005;326:472–474. doi: 10.1016/j.bbrc.2004.11.051.
    1. Vera-Ramirez L., Perez-Lopez P., Varela-Lopez A., Ramirez-Tortosa M., Battino M., Quiles J.L. Curcumin and liver disease. Biofactors. 2013;39:88–100. doi: 10.1002/biof.1057.
    1. Wright L.E., Frye J.B., Gorti B., Timmermann B.N., Funk J.L. Bioactivity of turmeric-derived curcuminoids and related metabolites in breast cancer. Curr. Pharm. Des. 2013;19:6218–6225. doi: 10.2174/1381612811319340013.
    1. Aggarwal B.B., Harikumar K.B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int. J. Biochem. Cell Biol. 2009;41:40–59. doi: 10.1016/j.biocel.2008.06.010.
    1. Panahi Y., Hosseini M.S., Khalili N., Naimi E., Simental-Mendia L.E., Majeed M., Sahebkar A. Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial. Biomed. Pharmacother. 2016;82:578–582. doi: 10.1016/j.biopha.2016.05.037.
    1. Kuptniratsaikul V., Dajpratham P., Taechaarpornkul W., Buntragulpoontawee M., Lukkanapichonchut P., Chootip C., Saengsuwan J., Tantayakom K., Laongpech S. Efficacy and safety of Curcuma domestica extracts compared with ibuprofen in patients with knee osteoarthritis: A multicenter study. Clin. Interv. Aging. 2014;9:451–458. doi: 10.2147/CIA.S58535.
    1. Mazzolani F., Togni S. Oral administration of a curcumin-phospholipid delivery system for the treatment of central serous chorioretinopathy: A 12-month follow-up study. Clin. Ophthalmol. 2013;7:939–945. doi: 10.2147/OPTH.S45820.
    1. Allegri P., Mastromarino A., Neri P. Management of chronic anterior uveitis relapses: Efficacy of oral phospholipidic curcumin treatment. Long-term follow-up. Clin. Ophthalmol. 2010;4:1201–1206. doi: 10.2147/OPTH.S13271.
    1. Trujillo J., Chirino Y.I., Molina-Jijón E., Andérica-Romero A.C., Tapia E., Pedraza-Chaverrí J. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol. 2013;1:448–456. doi: 10.1016/j.redox.2013.09.003.
    1. Anand P., Kunnumakkara A.B., Newman R.A., Aggarwal B.B. Bioavailability of curcumin: Problems and promises. Mol. Pharm. 2007;4:807–818. doi: 10.1021/mp700113r.
    1. Han H.K. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin. Drug Metab. Toxicol. 2011;7:721–729. doi: 10.1517/17425255.2011.570332.
    1. Shoba G., Joy D., Joseph T., Majeed M., Rajendran R., Srinivas P.S. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998;64:353–356. doi: 10.1055/s-2006-957450.
    1. Basnet P., Skalko-Basnet N. Curcumin: An anti-inflammatory molecule from a curry spice on the path to cancer treatment. Molecules. 2011;16:4567–4598. doi: 10.3390/molecules16064567.
    1. Lao C.D., Ruffin M.T., Normolle D., Heath D.D., Murray S.I., Bailey J.M., Boggs M.E., Crowell J., Rock C.L., Brenner D.E. Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 2006;6:10. doi: 10.1186/1472-6882-6-10.
    1. Kunnumakkara A.B., Bordoloi D., Harsha C., Banik K., Gupta S.C., Aggarwal B.B. Curcumin mediates anticancer effects by modulating multiple cell signaling pathways. Clin. Sci. 2017;131:1781–1799. doi: 10.1042/CS20160935.
    1. Lin Y.G., Kunnumakkara A.B., Nair A., Merritt W.M., Han L.Y., Armaiz-Pena G.N., Kamat A.A., Spannuth W.A., Gershenson D.M., Lutgendorf S.K., et al. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway. Clin. Cancer Res. 2007;13:3423–3430. doi: 10.1158/1078-0432.CCR-06-3072.
    1. Marchiani A., Rozzo C., Fadda A., Delogu G., Ruzza P. Curcumin and curcumin-like molecules: From spice to drugs. Curr. Med. Chem. 2014;21:204–222. doi: 10.2174/092986732102131206115810.
    1. Sahebkar A., Serbanc M.C., Ursoniuc S., Banach M. Effect of curcuminoids on oxidative stress: A systematic review and meta-analysis of randomized controlled trials. J. Funct. Foods. 2015;18:898–909. doi: 10.1016/j.jff.2015.01.005.
    1. Banach M., Serban C., Aronow W.S., Rysz J., Dragan S., Lerma E.V., Apetrii M., Covic A. Lipid, blood pressure and kidney update 2013. Int. Urol. Nephrol. 2014;46:947–961. doi: 10.1007/s11255-014-0657-6.
    1. Menon V.P., Sudheer A.R. Antioxidant and anti-inflammatory properties of curcumin. Adv. Exp. Med. Biol. 2007;595:105–125.
    1. Panahi Y., Alishiri G.H., Parvin S., Sahebkar A. Mitigation of systemic oxidative stress by curcuminoids in osteoarthritis: Results of a randomized controlled trial. J. Diet. Suppl. 2016;13:209–220. doi: 10.3109/19390211.2015.1008611.
    1. Priyadarsini K.I., Maity D.K., Naik G.H., Kumar M.S., Unnikrishnan M.K., Satav J.G., Mohan H. Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radic. Biol. Med. 2003;35:475–484. doi: 10.1016/S0891-5849(03)00325-3.
    1. Biswas S.K. Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox? Oxid. Med. Cell. Longev. 2016;2016:5698931. doi: 10.1155/2016/5698931.
    1. Jurenka J.S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: A review of preclinical and clinical research. Altern. Med. Rev. J. Clin. Ther. 2009;14:141–153.
    1. Recio M.C., Andujar I., Rios J.L. Anti-inflammatory agents from plants: Progress and potential. Curr. Med. Chem. 2012;19:2088–2103. doi: 10.2174/092986712800229069.
    1. Hunter D.J., Schofield D., Callander E. The individual and socioeconomic impact of osteoarthritis. Lancet Nat. Rev. Rheumatol. 2014;10:437–441. doi: 10.1038/nrrheum.2014.44.
    1. Vos T., Barber R.M., Bell B., Bertozzi-Villa A., Biryukov S., Bolliger I., Charlson F., Davis A., Degenhardt L., Dicker D., et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: A systematic analysis for the Global Burden of Disease Study. Lancet. 2013;386:743–800. doi: 10.1016/S0140-6736(15)60692-4.
    1. Goldring M.B. Osteoarthritis and cartilage: The role of cytokines. Curr. Rheumatol. Rep. 2000;2:459–465. doi: 10.1007/s11926-000-0021-y.
    1. Rahimnia A.R., Panahi Y., Alishiri A., Sharafi M., Sahebkar A. Impact of supplementation with curcuminoids on systemic inflammation in patients with knee osteoarthritis: Findings from a randomized double-blind placebo-controlled trial. Drug Res. 2015;65:521–525. doi: 10.1055/s-0034-1384536.
    1. Sahebkar A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil. Steril. 2010;94:e75–e76. doi: 10.1016/j.fertnstert.2010.07.1071.
    1. Henrotin Y., Priem F., Mobasheri A. Curcumin: A new paradigm and therapeutic opportunity for the treatment of osteoarthritis: Curcumin for osteoarthritis management. SpringerPlus. 2013;2:56. doi: 10.1186/2193-1801-2-56.
    1. Belcaro G., Cesarone M.R., Dugall M., Pellegrini L., Ledda A., Grossi M.G., Togni S., Appendino G. Product-evaluation registry of Meriva®, a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med. 2010;52:55–62.
    1. Belcaro G., Hosoi M., Pellegrini L., Appendino G., Ippolito E., Ricci A., Ledda A., Dugall M., Cesarone M.R., Maione C., et al. A controlled study of a lecithinized delivery system of curcumin (meriva®) to alleviate the adverse effects of cancer treatment. Phytother. Res. 2014;28:444–450. doi: 10.1002/ptr.5014.
    1. Chandran B., Goel A. A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis. Phytother. Res. 2012;26:1719–1725. doi: 10.1002/ptr.4639.
    1. Panahi Y., Rahimnia A.R., Sharafi M., Alishiri G., Saburi A., Sahebkar A. Curcuminoid treatment for knee osteoarthritis: A randomized double-blind placebo-controlled trial. Phytother. Res. 2014;28:1625–1631. doi: 10.1002/ptr.5174.
    1. Francesco D.P., Giuliana R., Eleonora A.D.M., Giovanni A., Federico F., Stefano T. Comparative evaluation of the pain-relieving properties of a lecithinized formulation of curcumin (Meriva®), nimesulide, and acetaminophen. J. Pain Res. 2013;6:201–205. doi: 10.2147/JPR.S42184.
    1. Daily J.W., Yang M., Park S. Efficacy of turmeric extracts and curcumin for alleviating the symptoms of ioint arthritis: A Systematic review and meta-snalysis of randomized clinical trials. J. Med. Food. 2016;19:717–729. doi: 10.1089/jmf.2016.3705.
    1. Na L.X., Li Y., Pan H.Z., Zhou X.L., Sun D.J., Meng M., Li X.X., Sun C.H. Curcuminoids exert glucose-lowering effect in type 2 diabetes by decreasing serum free fatty acids: A double-blind, placebo-controlled trial. Mol. Nutr. Food Res. 2013;57:1569–1577. doi: 10.1002/mnfr.201200131.
    1. Chuengsamarn S., Rattanamongkolgul S., Luechapudiporn R., Phisalaphong C., Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35:2121–2127. doi: 10.2337/dc12-0116.
    1. Bradford P.G. Curcumin and obesity. Biofactors. 2013;39:78–87. doi: 10.1002/biof.1074.
    1. Hlavackova L., Janegova A., Ulicna O., Janega P., Cerna A., Babal P. Spice up the hypertension diet—Curcumin and piperine prevent remodeling of aorta in experimental L-NAME induced hypertension. Nutr. Metab. 2011;8:72. doi: 10.1186/1743-7075-8-72.
    1. Sahebkar A. Are curcuminoids effective C-reactive protein-lowering agents in clinical practice? Evidence from a meta-analysis. Phytother. Res. 2013;28:633–642. doi: 10.1002/ptr.5045.
    1. Ak T., Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem. Biol. Interact. 2008;174:27–37. doi: 10.1016/j.cbi.2008.05.003.
    1. Sahebkar A., Mohammadi A., Atabati A., Rahiman S., Tavallaie S., Iranshahi M., Akhlaghi S., Ferns G.A., Ghayour-Mobarhan M. Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals. Phytother. Res. 2013;27:1883–1888. doi: 10.1002/ptr.4952.
    1. Mohammadi A., Sahebkar A., Iranshahi M., Amini M., Khojasteh R., Ghayour-Mobarhan M., Ferns GA. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial. Phytother. Res. 2013;27:374–379. doi: 10.1002/ptr.4715.
    1. DiSilvestro R.A., Joseph E., Zhao S., Bomser J. Diverse effects of a low dose supplement of lipidated curcumin in healthy middle-aged people. Nutr. J. 2012;11:79. doi: 10.1186/1475-2891-11-79.
    1. Sahebkar A. Curcuminoids for the management of hypertriglyceridaemia. Nat. Rev. Cardiol. 2014;11:123. doi: 10.1038/nrcardio.2013.140-c1.
    1. Soni K.B., Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J. Physiol. Pharmacol. 1992;36:273–275.
    1. Panahi Y., Khalili N., Hosseini M.S., Abbasinazari M., Sahebkar A. Lipid-modifying effects of adjunctive therapy with curcuminoids-piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial. Complement. Ther. Med. 2014;22:851–857. doi: 10.1016/j.ctim.2014.07.006.
    1. Panahi Y., Hosseini M.S., Khalili N., Naimi E., Simental-Mendia L.E., Majeed M., Sahebkar A. Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis. Clin. Nutr. 2015;34:1101–1108. doi: 10.1016/j.clnu.2014.12.019.
    1. Ganjali S., Sahebkar A., Mahdipour E., Jamialahmadi K., Torabi S., Akhlaghi S., Ferns G., Parizadeh S.M.R., Ghayour-Mobarhan M. Investigation of the effects of curcumin on serum cytokines in obese individuals: A randomized controlled trial. Sci. World J. 2014;2014:898361. doi: 10.1155/2014/898361.
    1. Strimpakos A., Sharm R. Curcumin: Preventive and therapeutic properties in laboratory studies and clinical trials. Food Chem. Toxicol. 2008;10:511–545. doi: 10.1089/ars.2007.1769.
    1. Epstein J., Sanderson I., Macdonald T. Curcumin as a therapeutic agent: The evidence from in vitro, animal and human studies. Br. J. Nutr. 2010;103:1545–1557. doi: 10.1017/S0007114509993667.
    1. Cox K.H., Pipingas A., Scholey A.B. Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population. J. Psychopharmacol. 2015;29:642–651. doi: 10.1177/0269881114552744.
    1. Chilelli N.C., Ragazzi E., Valentini R., Cosma C., Ferraresso S., Lapolla A., Sartore G. Curcumin and Boswellia serrata modulate the glyco-oxidative status and lipo-oxidation in master sthletes. Nutrients. 2016;8:745. doi: 10.3390/nu8110745.
    1. McFarlin B.K., Venable A.S., Henning A.L., Sampson J.N., Pennel K., Vingren J.L., Hill D.W. Reduced inflammatory and muscle damage biomarkers following oral supplementation with bioavailable curcumin. BBA Clin. 2016;5:72–78. doi: 10.1016/j.bbacli.2016.02.003.
    1. Drobnic F., Riera J., Appendino G., Togni S., Franceschi F., Valle X., Pons A., Tur J. Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva®): A randomised, placebo-controlled trial. J. ISSN. 2014;11:31. doi: 10.1186/1550-2783-11-31.
    1. Delecroix B., Abaïdia A.E., Leduc C., Dawson B., Dupont G. Curcumin and piperine supplementation and recovery following exercise induced muscle damage: A randomized controlled trial. J. Sports Sci. Med. 2017;16:147–153.
    1. Esmaily H., Sahebkar A., Iranshahi M., Ganjali S., Mohammadi A., Ferns G., Ghayour-Mobarhan M. An investigation of the effects of curcumin on anxiety and depression in obese individuals: A randomized controlled trial. Chin. J. Integr. Med. 2015;21:332–338. doi: 10.1007/s11655-015-2160-z.
    1. Kocaadam B., Şanlier N. Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit. Rev. Food Sci. Nutr. 2017;57:2889–2895. doi: 10.1080/10408398.2015.1077195.
    1. Sharma R.A., Euden S.A., Platton S.L., Cooke D.N., Shafayat A., Hewitt H.R., Marczylo T.H., Morgan B., Hemingway D., Plummer S.M. Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin. Cancer Res. 2004;10:6847–6854. doi: 10.1158/1078-0432.CCR-04-0744.

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