Bisphenol A exposure is associated with low-grade urinary albumin excretion in children of the United States

Leonardo Trasande, Teresa M Attina, Howard Trachtman, Leonardo Trasande, Teresa M Attina, Howard Trachtman

Abstract

Urinary bisphenol A (BPA), a widely used biomarker of exposure to BPA, has been associated with cardiometabolic derangements in laboratory studies and with low-grade albuminuria in Chinese adults. Despite the known unique vulnerability of children to environmental chemicals, no studies have examined associations of urinary BPA with albuminuria in children. As exposure to BPA is widespread in the United States population, we examined data from 710 children in the 2009-10 National Health and Nutrition Examination Survey with urinary BPA measurements and first morning urine samples with creatinine values. Controlled for a broad array of sociodemographic and environmental risk factors as well as insulin resistance and elevated cholesterol, children with the highest compared with the lowest quartile of urinary BPA had a significant 0.91 mg/g higher albumin-to-creatinine ratio, adjusted for the urinary BPA concentration. When the multivariable model was reprised substituting continuous measures of BPA, a significant 0.28 mg/g albumin-to-creatinine ratio increase was identified for each log unit increase in urinary BPA. Thus, an association of BPA exposure with low-grade albuminuria is consistent with previous results found in Chinese adults and documents this in children in the United States. Our findings broaden the array of adverse effects of BPA to include endothelial dysfunction as evidenced by the low-grade albuminuria and support proactive efforts to prevent harmful exposures.

Conflict of interest statement

DISCLOSURE STATEMENT

There are no competing financial or other interests to disclose.

Figures

Figure 1
Figure 1
This diagram outlines the number of patients in the NHANES survey during 2009–10 with measuremens of urinary BPA. This subgroup is divided into three groups based on the albumin:creatinine ratio -- low level albuminura, microalbuminuria, and macroalbuminuria.

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