Low dose of argatroban saline flushes anticoagulation in hemodialysis patients with high risk of bleeding
Zhang Yixiong, Ning Jianping, Li Yanchao, Dai Siyuan, Zhang Yixiong, Ning Jianping, Li Yanchao, Dai Siyuan
Abstract
Background: Anticoagulation in hemodialysis (HD) patients with high risk of bleeding is still an intractable problem.
Method: A total of 80 HD sessions with high risk of bleeding were completed with either heparin-free (HF) or low dose of argatroban saline flushes (LASF) anticoagulation. Clinical clot formation in the pipeline and dialyzer was inspected to evaluate the local anticoagulation efficiency; prothrombin time (PT), activated partial thromboplastin time (aPTT), and D-dimer were tested to investigate the influence on the whole body coagulation system; urea reduction ratio (URR) and Kt/V were used to evaluate the efficiency of dialysis.
Results: Comparing with HF, LASF showed a satisfactory efficiency in reducing the clot formation and the URR and Kt/V of it were also higher.
Conclusions: Low dose of argatroban saline flushes is a feasible and safe alternative anticoagulation protocol in HD patients with high risk of bleeding.
Source: PubMed