A new era in the management of pulmonary arterial hypertension related to scleroderma: endothelin receptor antagonism
E Hachulla, J G Coghlan, E Hachulla, J G Coghlan
Abstract
Evidence suggests that endothelin may have a fundamental role in scleroderma pathogenesis, including pulmonary arterial hypertension (PAH)--a leading cause of death in patients with scleroderma. Development of a new class of drug, endothelin receptor antagonists, heralds an improved outlook for patients with scleroderma and related diseases. Heightened vigilance towards early detection of PAH in scleroderma and a multidisciplinary approach to diagnosis and treatment may improve clinical outcomes for these patients.
Figures
References
- Nature. 1988 Mar 31;332(6163):411-5
- Prog Cardiovasc Dis. 1988 Nov-Dec;31(3):205-38
- N Engl J Med. 1992 Jul 9;327(2):76-81
- Q J Med. 1992 Feb;82(298):139-48
- J Rheumatol. 1992 Oct;19(10):1566-71
- N Engl J Med. 1993 Jun 17;328(24):1732-9
- J Rheumatol. 1994 Jul;21(7):1268-76
- Intern Med. 1994 Oct;33(10):579-82
- J Rheumatol. 1995 Nov;22(11):2100-2
- J Appl Physiol (1985). 1995 Dec;79(6):2122-31
- Br J Rheumatol. 1996 Oct;35(10):989-93
- Br J Rheumatol. 1996 Nov;35(11):1122-6
- Chest. 1996 Dec;110(6):1515-9
- Br J Rheumatol. 1997 Feb;36(2):239-43
- Int J Cardiol. 1997 Jun 27;60(1):31-9
- J Dermatol Sci. 1997 Nov;16(1):38-44
- Semin Cutan Med Surg. 1998 Mar;17(1):48-54
- Eur Respir J. 1998 Aug;12(2):265-70
- Lancet. 1998 Aug 29;352(9129):719-25
- Thorax. 1999 Mar;54(3):273-7
- Ann Intern Med. 2000 Mar 21;132(6):425-34
- Am J Respir Crit Care Med. 2000 Feb;161(2 Pt 1):487-92
- Ann Rheum Dis. 2000 May;59(5):359-67
- Baillieres Best Pract Res Clin Rheumatol. 2000 Mar;14(1):17-35
- J Rheumatol. 2001 Jul;28(7):1573-6
- Heart. 2001 Sep;86 Suppl 1:I1-13
- Lancet. 2001 Oct 6;358(9288):1119-23
- Rev Med Interne. 2001 Sep;22(9):819-29
- Expert Opin Investig Drugs. 2001 Jul;10(7):1291-308
- Rev Med Interne. 2002 Jan;23(1):41-54
- Am J Respir Crit Care Med. 2002 Mar 15;165(6):800-4
- N Engl J Med. 2002 Mar 21;346(12):896-903
- Eur Respir J. 2002 Mar;19(3):571-6
- J Am Coll Cardiol. 2002 May 1;39(9):1496-502
- J Cardiovasc Pharmacol Ther. 2002 Jan;7(1):9-19
- Expert Opin Investig Drugs. 2002 Jul;11(7):991-1002
- N Engl J Med. 2002 Aug 1;347(5):322-9
- Ann Med Interne (Paris). 2002 Jun;153(4):250-9
- Arch Intern Med. 2002 Sep 23;162(17):1925-33
- Rheumatology (Oxford). 2003 Jan;42(1):71-5
- Ann Rheum Dis. 2003 Feb;62(2):97-9
- Arthritis Rheum. 2003 Feb;48(2):516-22
- Chest. 2003 Feb;123(2):344-50
- Am J Respir Crit Care Med. 2003 Feb 15;167(4):580-6
- J Am Coll Cardiol. 2003 Apr 16;41(8):1380-6
- Arthritis Rheum. 2003 Aug;48(8):2246-55
- Ann Rheum Dis. 2003 Nov;62(11):1088-93
- Am J Respir Crit Care Med. 2004 Feb 15;169(4):441-7
- Ann Intern Med. 1971 May;74(5):714-21
- Arthritis Rheum. 1980 May;23(5):581-90
Source: PubMed