Wnt/β-catenin signaling and disease
Hans Clevers, Roel Nusse, Hans Clevers, Roel Nusse
Abstract
The WNT signal transduction cascade controls myriad biological phenomena throughout development and adult life of all animals. In parallel, aberrant Wnt signaling underlies a wide range of pathologies in humans. In this Review, we provide an update of the core Wnt/β-catenin signaling pathway, discuss how its various components contribute to disease, and pose outstanding questions to be addressed in the future.
Copyright © 2012 Elsevier Inc. All rights reserved.
Source: PubMed