Artificial Pancreas Project at Cambridge 2013

Abstract

The development and clinical testing of closed-loop systems (the artificial pancreas) is underpinned by advances in continuous glucose monitoring and benefits from concerted academic and industry collaborative efforts. This review describes the progress of the Artificial Pancreas Project at the University of Cambridge from 2006 to 2014. Initial studies under controlled laboratory conditions, designed to collect representative safety and performance data, were followed by short to medium free-living unsupervised outpatient studies demonstrating the safety and efficacy of closed-loop insulin delivery using a model predictive control algorithm. Accompanying investigations included assessment of the psychosocial impact and key factors affecting glucose control such as insulin kinetics and glucose absorption. Translation to other disease conditions such as critical illness and Type 2 diabetes took place. It is concluded that innovation of iteratively enhanced closed-loop systems will provide tangible means to improve outcomes and quality of life in people with Type 1 diabetes and their families in the next decade.

Conflict of interest statement

Competing interests

RH reports having received speaker honoraria from Minimed Medtronic, Lifescan, Eli Lilly, BBraun, and Novo Nordisk, serving on advisory panel for Animas, Minimed Medtronic, Merck, and Eli Lilly, receiving license fees from BBraun, Medtronic, and Becton Dickinson, having served as a consultant BBraun, Sanofi-Aventis, and Profil, and patent applications.

© 2015 The Author. Diabetic Medicine © 2015 Diabetes UK.