Chronic rhinosinusitis and emerging treatment options

Patorn Piromchai, Pornthep Kasemsiri, Supawan Laohasiriwong, Sanguansak Thanaviratananich, Patorn Piromchai, Pornthep Kasemsiri, Supawan Laohasiriwong, Sanguansak Thanaviratananich

Abstract

This review describes the epidemiology and various treatments in chronic rhinosinusitis (CRS) with nasal polyps (CRSwNP) and CRS without nasal polyps (CRSsNP). Evidence for short-term use of systemic corticosteroids has been shown to be favorable in CRSwNP, but still limited in CRSsNP. Topical corticosteroids improve symptom scores in both CRS subgroups. The role of microbes in CRS is still controversial. Culture-directed antibiotics are recommended for CRSsNP with exacerbation. Long-term use of low dosage antibiotics is recommended for CRSsNP for their anti-inflammatory effects. Other emerging treatment options are also discussed.

Keywords: chronic; nasal polyps; rhinosinusitis; sinus; therapy.

Figures

Figure 1
Figure 1
Management scheme for chronic rhinosinusitis without nasal polyps. Abbreviation: Ig, immunoglobulin.
Figure 2
Figure 2
Management scheme for chronic rhinosinusitis with nasal polyps. Abbreviation: CT, computed tomography.

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