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Multi-Ingredient Supplementation in Professional Football Players (TCP-Soccer)

30. Juni 2026 aktualisiert von: Krzysztof Mizera, Vizja University in Warsaw

Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players

This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.

Studienübersicht

Status

Abgeschlossen

Bedingungen

Intervention / Behandlung

Detaillierte Beschreibung

The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.

Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.

Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.

The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.

Studientyp

Interventionell

Einschreibung (Tatsächlich)

97

Phase

  • Unzutreffend

Kontakte und Standorte

Dieser Abschnitt enthält die Kontaktdaten derjenigen, die die Studie durchführen, und Informationen darüber, wo diese Studie durchgeführt wird.

Studienorte

  • Polen
      • Lodz, Polen
        • Professional Football Training Center
      • Warsaw, Polen
        • Professional Football Training Center
      • Wroclaw, Polen
        • Professional Football Training Center
  • Spanien
      • Alicante, Spanien
        • Professional Football Training Center
  • Ungarn
      • Budapest, Ungarn
        • Professional Football Training Center

Teilnahmekriterien

Forscher suchen nach Personen, die einer bestimmten Beschreibung entsprechen, die als Auswahlkriterien bezeichnet werden. Einige Beispiele für diese Kriterien sind der allgemeine Gesundheitszustand einer Person oder frühere Behandlungen.

Zulassungskriterien

Studienberechtigtes Alter

  • Erwachsene

Akzeptiert gesunde Freiwillige

Ja

Beschreibung

Inclusion Criteria:

-

Inclusion Criteria:

  • Professional male football players aged 18-35 years
  • Regular participation in team training and competitive matches
  • Clinically healthy status confirmed prior to participation
  • Written informed consent provided

Exclusion Criteria:

  • Current musculoskeletal injury or illness
  • Chronic metabolic, cardiovascular, or neurological disease
  • Regular medication use
  • Current use of dietary supplements or ergogenic aids
  • Smoking or excessive alcohol consumption
  • Known hypersensitivity to any study supplement ingredient

Exclusion Criteria:

-

Studienplan

Dieser Abschnitt enthält Einzelheiten zum Studienplan, einschließlich des Studiendesigns und der Messung der Studieninhalte.

Wie ist die Studie aufgebaut?

Designdetails

  • Hauptzweck: Sonstiges
  • Zuteilung: Zufällig
  • Interventionsmodell: Parallele Zuordnung
  • Maskierung: Verdreifachen

Waffen und Interventionen

Teilnehmergruppe / Arm
Intervention / Behandlung
Placebo-Komparator: P
Participants will receive visually identical placebo capsules for 14 days.
Sonstiges: Placebo
Placebo capsules administered daily during the 14-day intervention period
Experimental: TC
Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days.
Nahrungsergänzungsmittel: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Nahrungsergänzungsmittel: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Experimental: TCP-300
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days.
Nahrungsergänzungsmittel: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Nahrungsergänzungsmittel: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Nahrungsergänzungsmittel: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.
Experimental: TCP-600
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days.
Nahrungsergänzungsmittel: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Nahrungsergänzungsmittel: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Nahrungsergänzungsmittel: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.

Was misst die Studie?

Primäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
30 m sprint time
Zeitfenster: Baseline and after 14 days of supplementation

Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis.

Unit of Measure: seconds
Baseline and after 14 days of supplementation

Sekundäre Ergebnismessungen

Ergebnis Maßnahme
Maßnahmenbeschreibung
Zeitfenster
Visual reaction time
Zeitfenster: Baseline and after 14 days of supplementation
Mean response time to a visual stimulus, measured using a validated visual reaction time test.
Baseline and after 14 days of supplementation
Auditory reaction time
Zeitfenster: Baseline and after 14 days of supplementation
Mean response time to an auditory stimulus, measured using a computerized auditory reaction time test.
Baseline and after 14 days of supplementation
Total distance covered
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

Total distance covered during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters
After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

Distance covered per minute during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters per minute
After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

Description:

Distance covered at running speeds above 19.8 km/h during the standardized football-specific training session, measured using a 10-Hz GPS tracking system.

Unit of Measure: meters
After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

Total number of sprint efforts performed during the standardized football-specific training session. Sprinting will be defined as running speed above 25.0 km/h and measured using a 10-Hz GPS tracking system.

Unit of Measure: number of sprints
After 14 days of supplementation, during the standardized football-specific training session
Player Load
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

External training load during the standardized football-specific training session, measured using triaxial accelerometry integrated with the GPS tracking system.

Unit of Measure: arbitrary units
After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Zeitfenster: Daily during the 14-day supplementation period
Resting heart rate variability assessed in the morning using the root mean square of successive differences between normal heartbeats. HRV will be measured using a heart rate sensor or wearable device under standardized resting conditions. Unit of Measure: milliseconds
Daily during the 14-day supplementation period
Sleep duration
Zeitfenster: Daily during the 14-day supplementation period
Total sleep duration assessed using wearable sleep monitoring. Unit of Measure: hours
Daily during the 14-day supplementation period
Sleep efficiency
Zeitfenster: Daily during the 14-day supplementation period

Percentage of time in bed spent asleep, assessed using wearable sleep monitoring.

Unit of Measure: percent
Daily during the 14-day supplementation period
Subjective fatigue
Zeitfenster: Daily during the 14-day supplementation period
Subjective fatigue assessed using the fatigue item of the Hooper Index questionnaire on a 1-7 scale, where higher values indicate greater fatigue. Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Muscle soreness
Zeitfenster: Daily during the 14-day supplementation period

Perceived lower-limb muscle soreness assessed using a 0-10 delayed onset muscle soreness scale, where higher values indicate greater soreness.

Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Stroop task reaction time
Zeitfenster: Baseline and after 14 days of supplementation
Mean response time during a modified computerized Stroop task assessing cognitive fatigue, inhibitory control, sustained attention, and information processing speed. Unit of Measure: seconds
Baseline and after 14 days of supplementation
Stroop task accuracy
Zeitfenster: Baseline and after 14 days of supplementation
Percentage of correct responses during a modified computerized Stroop task. Unit of Measure: percent
Baseline and after 14 days of supplementation
Stroop task error rate
Zeitfenster: Baseline and after 14 days of supplementation
Number of incorrect responses during a modified computerized Stroop task. Unit of Measure: number of errors
Baseline and after 14 days of supplementation
Perceived mental fatigue
Zeitfenster: Baseline and after 14 days of supplementation
Subjective perceived mental fatigue assessed using a 0-10 visual analogue scale, where higher values indicate greater perceived mental fatigue. Unit of Measure: score on a 0-10 scale
Baseline and after 14 days of supplementation
Change in sprint count between first and second half
Zeitfenster: After 14 days of supplementation, during the standardized football-specific training session

Percentage decline in the number of sprints between the first and second half of the standardized football-specific training session. Sprint change will be calculated as: [(second half value - first half value) / first half value] × 100.

Unit of Measure: percent
After 14 days of supplementation, during the standardized football-specific training session

Mitarbeiter und Ermittler

Hier finden Sie Personen und Organisationen, die an dieser Studie beteiligt sind.

Sponsor

Vizja University in Warsaw

Ermittler

  • Hauptermittler: Krzysztof Maciej MIZERA, PhD, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

Studienaufzeichnungsdaten

Diese Daten verfolgen den Fortschritt der Übermittlung von Studienaufzeichnungen und zusammenfassenden Ergebnissen an ClinicalTrials.gov. Studienaufzeichnungen und gemeldete Ergebnisse werden von der National Library of Medicine (NLM) überprüft, um sicherzustellen, dass sie bestimmten Qualitätskontrollstandards entsprechen, bevor sie auf der öffentlichen Website veröffentlicht werden.

Haupttermine studieren

Studienbeginn (Tatsächlich)

14. Juni 2026

Primärer Abschluss (Tatsächlich)

30. Juni 2026

Studienabschluss (Tatsächlich)

30. Juni 2026

Studienanmeldedaten

Zuerst eingereicht

13. Mai 2026

Zuerst eingereicht, das die QC-Kriterien erfüllt hat

17. Mai 2026

Zuerst gepostet (Tatsächlich)

22. Mai 2026

Studienaufzeichnungsaktualisierungen

Letztes Update gepostet (Tatsächlich)

2. Juli 2026

Letztes eingereichtes Update, das die QC-Kriterien erfüllt

30. Juni 2026

Zuletzt verifiziert

1. Juni 2026

Mehr Informationen

Begriffe im Zusammenhang mit dieser Studie

Schlüsselwörter

Zusätzliche relevante MeSH-Bedingungen

Andere Studien-ID-Nummern

  • MIZERA-FOOTBALL-2026

Plan für individuelle Teilnehmerdaten (IPD)

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UNENTSCHIEDEN

Beschreibung des IPD-Plans

Data sharing plans have not yet been finalized.

Arzneimittel- und Geräteinformationen, Studienunterlagen

Studiert ein von der US-amerikanischen FDA reguliertes Arzneimittelprodukt

Nein

Studiert ein von der US-amerikanischen FDA reguliertes Geräteprodukt

Nein

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