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Multi-Ingredient Supplementation in Professional Football Players (TCP-Soccer)

30 июня 2026 г. обновлено: Krzysztof Mizera, Vizja University in Warsaw

Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players

This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.

Обзор исследования

Статус

Завершенный

Условия

Вмешательство/лечение

Подробное описание

The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.

Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.

Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.

The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.

Тип исследования

Интервенционный

Регистрация (Действительный)

97

Фаза

  • Непригодный

Контакты и местонахождение

В этом разделе приведены контактные данные лиц, проводящих исследование, и информация о том, где проводится это исследование.

Места учебы

  • Венгрия
      • Budapest, Венгрия
        • Professional Football Training Center
  • Испания
      • Alicante, Испания
        • Professional Football Training Center
  • Польша
      • Lodz, Польша
        • Professional Football Training Center
      • Warsaw, Польша
        • Professional Football Training Center
      • Wroclaw, Польша
        • Professional Football Training Center

Критерии участия

Исследователи ищут людей, которые соответствуют определенному описанию, называемому критериям приемлемости. Некоторыми примерами этих критериев являются общее состояние здоровья человека или предшествующее лечение.

Критерии приемлемости

Возраст, подходящий для обучения

  • Взрослый

Принимает здоровых добровольцев

Да

Описание

Inclusion Criteria:

-

Inclusion Criteria:

  • Professional male football players aged 18-35 years
  • Regular participation in team training and competitive matches
  • Clinically healthy status confirmed prior to participation
  • Written informed consent provided

Exclusion Criteria:

  • Current musculoskeletal injury or illness
  • Chronic metabolic, cardiovascular, or neurological disease
  • Regular medication use
  • Current use of dietary supplements or ergogenic aids
  • Smoking or excessive alcohol consumption
  • Known hypersensitivity to any study supplement ingredient

Exclusion Criteria:

-

Учебный план

В этом разделе представлена ​​подробная информация о плане исследования, в том числе о том, как планируется исследование и что оно измеряет.

Как устроено исследование?

Детали дизайна

  • Основная цель: Другой
  • Распределение: Рандомизированный
  • Интервенционная модель: Параллельное назначение
  • Маскировка: Тройной

Оружие и интервенции

Группа участников / Армия
Вмешательство/лечение
Плацебо Компаратор: P
Participants will receive visually identical placebo capsules for 14 days.
Другой: Placebo
Placebo capsules administered daily during the 14-day intervention period
Экспериментальный: TC
Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days.
Диетическая добавка: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Диетическая добавка: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Экспериментальный: TCP-300
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days.
Диетическая добавка: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Диетическая добавка: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Диетическая добавка: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.
Экспериментальный: TCP-600
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days.
Диетическая добавка: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Диетическая добавка: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Диетическая добавка: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.

Что измеряет исследование?

Первичные показатели результатов

Мера результата
Мера Описание
Временное ограничение
30 m sprint time
Временное ограничение: Baseline and after 14 days of supplementation

Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis.

Unit of Measure: seconds
Baseline and after 14 days of supplementation

Вторичные показатели результатов

Мера результата
Мера Описание
Временное ограничение
Visual reaction time
Временное ограничение: Baseline and after 14 days of supplementation
Mean response time to a visual stimulus, measured using a validated visual reaction time test.
Baseline and after 14 days of supplementation
Auditory reaction time
Временное ограничение: Baseline and after 14 days of supplementation
Mean response time to an auditory stimulus, measured using a computerized auditory reaction time test.
Baseline and after 14 days of supplementation
Total distance covered
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

Total distance covered during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters
After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

Distance covered per minute during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters per minute
After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

Description:

Distance covered at running speeds above 19.8 km/h during the standardized football-specific training session, measured using a 10-Hz GPS tracking system.

Unit of Measure: meters
After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

Total number of sprint efforts performed during the standardized football-specific training session. Sprinting will be defined as running speed above 25.0 km/h and measured using a 10-Hz GPS tracking system.

Unit of Measure: number of sprints
After 14 days of supplementation, during the standardized football-specific training session
Player Load
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

External training load during the standardized football-specific training session, measured using triaxial accelerometry integrated with the GPS tracking system.

Unit of Measure: arbitrary units
After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Временное ограничение: Daily during the 14-day supplementation period
Resting heart rate variability assessed in the morning using the root mean square of successive differences between normal heartbeats. HRV will be measured using a heart rate sensor or wearable device under standardized resting conditions. Unit of Measure: milliseconds
Daily during the 14-day supplementation period
Sleep duration
Временное ограничение: Daily during the 14-day supplementation period
Total sleep duration assessed using wearable sleep monitoring. Unit of Measure: hours
Daily during the 14-day supplementation period
Sleep efficiency
Временное ограничение: Daily during the 14-day supplementation period

Percentage of time in bed spent asleep, assessed using wearable sleep monitoring.

Unit of Measure: percent
Daily during the 14-day supplementation period
Subjective fatigue
Временное ограничение: Daily during the 14-day supplementation period
Subjective fatigue assessed using the fatigue item of the Hooper Index questionnaire on a 1-7 scale, where higher values indicate greater fatigue. Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Muscle soreness
Временное ограничение: Daily during the 14-day supplementation period

Perceived lower-limb muscle soreness assessed using a 0-10 delayed onset muscle soreness scale, where higher values indicate greater soreness.

Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Stroop task reaction time
Временное ограничение: Baseline and after 14 days of supplementation
Mean response time during a modified computerized Stroop task assessing cognitive fatigue, inhibitory control, sustained attention, and information processing speed. Unit of Measure: seconds
Baseline and after 14 days of supplementation
Stroop task accuracy
Временное ограничение: Baseline and after 14 days of supplementation
Percentage of correct responses during a modified computerized Stroop task. Unit of Measure: percent
Baseline and after 14 days of supplementation
Stroop task error rate
Временное ограничение: Baseline and after 14 days of supplementation
Number of incorrect responses during a modified computerized Stroop task. Unit of Measure: number of errors
Baseline and after 14 days of supplementation
Perceived mental fatigue
Временное ограничение: Baseline and after 14 days of supplementation
Subjective perceived mental fatigue assessed using a 0-10 visual analogue scale, where higher values indicate greater perceived mental fatigue. Unit of Measure: score on a 0-10 scale
Baseline and after 14 days of supplementation
Change in sprint count between first and second half
Временное ограничение: After 14 days of supplementation, during the standardized football-specific training session

Percentage decline in the number of sprints between the first and second half of the standardized football-specific training session. Sprint change will be calculated as: [(second half value - first half value) / first half value] × 100.

Unit of Measure: percent
After 14 days of supplementation, during the standardized football-specific training session

Соавторы и исследователи

Здесь вы найдете людей и организации, участвующие в этом исследовании.

Спонсор

Vizja University in Warsaw

Следователи

  • Главный следователь: Krzysztof Maciej MIZERA, PhD, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

Даты записи исследования

Эти даты отслеживают ход отправки отчетов об исследованиях и сводных результатов на сайт ClinicalTrials.gov. Записи исследований и сообщаемые результаты проверяются Национальной медицинской библиотекой (NLM), чтобы убедиться, что они соответствуют определенным стандартам контроля качества, прежде чем публиковать их на общедоступном веб-сайте.

Изучение основных дат

Начало исследования (Действительный)

14 июня 2026 г.

Первичное завершение (Действительный)

30 июня 2026 г.

Завершение исследования (Действительный)

30 июня 2026 г.

Даты регистрации исследования

Первый отправленный

13 мая 2026 г.

Впервые представлено, что соответствует критериям контроля качества

17 мая 2026 г.

Первый опубликованный (Действительный)

22 мая 2026 г.

Обновления учебных записей

Последнее опубликованное обновление (Действительный)

2 июля 2026 г.

Последнее отправленное обновление, отвечающее критериям контроля качества

30 июня 2026 г.

Последняя проверка

1 июня 2026 г.

Дополнительная информация

Термины, связанные с этим исследованием

Ключевые слова

Дополнительные соответствующие термины MeSH

Другие идентификационные номера исследования

  • MIZERA-FOOTBALL-2026

Планирование данных отдельных участников (IPD)

Планируете делиться данными об отдельных участниках (IPD)?

НЕ РЕШЕНО

Описание плана IPD

Data sharing plans have not yet been finalized.

Информация о лекарствах и устройствах, исследовательские документы

Изучает лекарственный продукт, регулируемый FDA США.

Нет

Изучает продукт устройства, регулируемый Управлением по санитарному надзору за качеством пищевых продуктов и медикаментов США.

Нет

Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .

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