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Multi-Ingredient Supplementation in Professional Football Players (TCP-Soccer)

30 de junho de 2026 atualizado por: Krzysztof Mizera, Vizja University in Warsaw

Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players

This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.

Visão geral do estudo

Status

Concluído

Condições

Intervenção / Tratamento

Descrição detalhada

The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.

Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.

Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.

The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.

Tipo de estudo

Intervencional

Inscrição (Real)

97

Estágio

  • Não aplicável

Contactos e Locais

Esta seção fornece os detalhes de contato para aqueles que conduzem o estudo e informações sobre onde este estudo está sendo realizado.

Locais de estudo

  • Espanha
      • Alicante, Espanha
        • Professional Football Training Center
  • Hungria
      • Budapest, Hungria
        • Professional Football Training Center
  • Polônia
      • Lodz, Polônia
        • Professional Football Training Center
      • Warsaw, Polônia
        • Professional Football Training Center
      • Wroclaw, Polônia
        • Professional Football Training Center

Critérios de participação

Os pesquisadores procuram pessoas que se encaixem em uma determinada descrição, chamada de critérios de elegibilidade. Alguns exemplos desses critérios são a condição geral de saúde de uma pessoa ou tratamentos anteriores.

Critérios de elegibilidade

Idades elegíveis para estudo

  • Adulto

Aceita Voluntários Saudáveis

Sim

Descrição

Inclusion Criteria:

-

Inclusion Criteria:

  • Professional male football players aged 18-35 years
  • Regular participation in team training and competitive matches
  • Clinically healthy status confirmed prior to participation
  • Written informed consent provided

Exclusion Criteria:

  • Current musculoskeletal injury or illness
  • Chronic metabolic, cardiovascular, or neurological disease
  • Regular medication use
  • Current use of dietary supplements or ergogenic aids
  • Smoking or excessive alcohol consumption
  • Known hypersensitivity to any study supplement ingredient

Exclusion Criteria:

-

Plano de estudo

Esta seção fornece detalhes do plano de estudo, incluindo como o estudo é projetado e o que o estudo está medindo.

Como o estudo é projetado?

Detalhes do projeto

  • Finalidade Principal: Outro
  • Alocação: Randomizado
  • Modelo Intervencional: Atribuição Paralela
  • Mascaramento: Triplo

Armas e Intervenções

Grupo de Participantes / Braço
Intervenção / Tratamento
Comparador de Placebo: P
Participants will receive visually identical placebo capsules for 14 days.
Outro: Placebo
Placebo capsules administered daily during the 14-day intervention period
Experimental: TC
Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days.
Suplemento dietético: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Suplemento dietético: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Experimental: TCP-300
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days.
Suplemento dietético: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Suplemento dietético: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Suplemento dietético: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.
Experimental: TCP-600
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days.
Suplemento dietético: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Suplemento dietético: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Suplemento dietético: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.

O que o estudo está medindo?

Medidas de resultados primários

Medida de resultado
Descrição da medida
Prazo
30 m sprint time
Prazo: Baseline and after 14 days of supplementation

Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis.

Unit of Measure: seconds
Baseline and after 14 days of supplementation

Medidas de resultados secundários

Medida de resultado
Descrição da medida
Prazo
Visual reaction time
Prazo: Baseline and after 14 days of supplementation
Mean response time to a visual stimulus, measured using a validated visual reaction time test.
Baseline and after 14 days of supplementation
Auditory reaction time
Prazo: Baseline and after 14 days of supplementation
Mean response time to an auditory stimulus, measured using a computerized auditory reaction time test.
Baseline and after 14 days of supplementation
Total distance covered
Prazo: After 14 days of supplementation, during the standardized football-specific training session

Total distance covered during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters
After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Prazo: After 14 days of supplementation, during the standardized football-specific training session

Distance covered per minute during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters per minute
After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Prazo: After 14 days of supplementation, during the standardized football-specific training session

Description:

Distance covered at running speeds above 19.8 km/h during the standardized football-specific training session, measured using a 10-Hz GPS tracking system.

Unit of Measure: meters
After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Prazo: After 14 days of supplementation, during the standardized football-specific training session

Total number of sprint efforts performed during the standardized football-specific training session. Sprinting will be defined as running speed above 25.0 km/h and measured using a 10-Hz GPS tracking system.

Unit of Measure: number of sprints
After 14 days of supplementation, during the standardized football-specific training session
Player Load
Prazo: After 14 days of supplementation, during the standardized football-specific training session

External training load during the standardized football-specific training session, measured using triaxial accelerometry integrated with the GPS tracking system.

Unit of Measure: arbitrary units
After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Prazo: Daily during the 14-day supplementation period
Resting heart rate variability assessed in the morning using the root mean square of successive differences between normal heartbeats. HRV will be measured using a heart rate sensor or wearable device under standardized resting conditions. Unit of Measure: milliseconds
Daily during the 14-day supplementation period
Sleep duration
Prazo: Daily during the 14-day supplementation period
Total sleep duration assessed using wearable sleep monitoring. Unit of Measure: hours
Daily during the 14-day supplementation period
Sleep efficiency
Prazo: Daily during the 14-day supplementation period

Percentage of time in bed spent asleep, assessed using wearable sleep monitoring.

Unit of Measure: percent
Daily during the 14-day supplementation period
Subjective fatigue
Prazo: Daily during the 14-day supplementation period
Subjective fatigue assessed using the fatigue item of the Hooper Index questionnaire on a 1-7 scale, where higher values indicate greater fatigue. Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Muscle soreness
Prazo: Daily during the 14-day supplementation period

Perceived lower-limb muscle soreness assessed using a 0-10 delayed onset muscle soreness scale, where higher values indicate greater soreness.

Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Stroop task reaction time
Prazo: Baseline and after 14 days of supplementation
Mean response time during a modified computerized Stroop task assessing cognitive fatigue, inhibitory control, sustained attention, and information processing speed. Unit of Measure: seconds
Baseline and after 14 days of supplementation
Stroop task accuracy
Prazo: Baseline and after 14 days of supplementation
Percentage of correct responses during a modified computerized Stroop task. Unit of Measure: percent
Baseline and after 14 days of supplementation
Stroop task error rate
Prazo: Baseline and after 14 days of supplementation
Number of incorrect responses during a modified computerized Stroop task. Unit of Measure: number of errors
Baseline and after 14 days of supplementation
Perceived mental fatigue
Prazo: Baseline and after 14 days of supplementation
Subjective perceived mental fatigue assessed using a 0-10 visual analogue scale, where higher values indicate greater perceived mental fatigue. Unit of Measure: score on a 0-10 scale
Baseline and after 14 days of supplementation
Change in sprint count between first and second half
Prazo: After 14 days of supplementation, during the standardized football-specific training session

Percentage decline in the number of sprints between the first and second half of the standardized football-specific training session. Sprint change will be calculated as: [(second half value - first half value) / first half value] × 100.

Unit of Measure: percent
After 14 days of supplementation, during the standardized football-specific training session

Colaboradores e Investigadores

É aqui que você encontrará pessoas e organizações envolvidas com este estudo.

Patrocinador

Vizja University in Warsaw

Investigadores

  • Investigador principal: Krzysztof Maciej MIZERA, PhD, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

Datas de registro do estudo

Essas datas acompanham o progresso do registro do estudo e os envios de resumo dos resultados para ClinicalTrials.gov. Os registros do estudo e os resultados relatados são revisados ​​pela National Library of Medicine (NLM) para garantir que atendam aos padrões específicos de controle de qualidade antes de serem publicados no site público.

Datas Principais do Estudo

Início do estudo (Real)

14 de junho de 2026

Conclusão Primária (Real)

30 de junho de 2026

Conclusão do estudo (Real)

30 de junho de 2026

Datas de inscrição no estudo

Enviado pela primeira vez

13 de maio de 2026

Enviado pela primeira vez que atendeu aos critérios de CQ

17 de maio de 2026

Primeira postagem (Real)

22 de maio de 2026

Atualizações de registro de estudo

Última Atualização Postada (Real)

2 de julho de 2026

Última atualização enviada que atendeu aos critérios de controle de qualidade

30 de junho de 2026

Última verificação

1 de junho de 2026

Mais Informações

Termos relacionados a este estudo

Palavras-chave

Termos MeSH relevantes adicionais

Outros números de identificação do estudo

  • MIZERA-FOOTBALL-2026

Plano para dados de participantes individuais (IPD)

Planeja compartilhar dados de participantes individuais (IPD)?

INDECISO

Descrição do plano IPD

Data sharing plans have not yet been finalized.

Informações sobre medicamentos e dispositivos, documentos de estudo

Estuda um medicamento regulamentado pela FDA dos EUA

Não

Estuda um produto de dispositivo regulamentado pela FDA dos EUA

Não

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