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Multi-Ingredient Supplementation in Professional Football Players (TCP-Soccer)

30 giugno 2026 aggiornato da: Krzysztof Mizera, Vizja University in Warsaw

Dose-Dependent Effects of Multi-Ingredient Supplementation on Physical Performance, Recovery, and Cognitive Function in Professional Football Players

This randomized double-blind placebo-controlled trial will investigate the effects of multi-ingredient supplementation containing taurine, caffeine, and phosphatidylserine on physical performance, cognitive function, cognitive fatigue responses, recovery, sleep quality, and autonomic nervous system activity in elite male soccer players. Participants will complete a 14-day supplementation protocol and undergo football-specific performance, reaction-time, cognitive-fatigue, recovery, and sleep-related assessments before and after the intervention. The study aims to determine whether phosphatidylserine dose influences physical, cognitive, fatigue-related, and recovery-related outcomes when combined with taurine and caffeine.

Panoramica dello studio

Stato

Completato

Condizioni

Intervento / Trattamento

Descrizione dettagliata

The planned study will be a randomized, double-blind, placebo-controlled trial designed as a continuation and extension of previous research on multi-ingredient supplementation in professional football players. The primary aim will be to investigate the dose-dependent effects of phosphatidylserine combined with taurine and caffeine under standardized football-specific training conditions and acute cognitive-fatigue conditions.

Approximately 80 professional male football players competing at national level will be randomly assigned to four groups: placebo, taurine + caffeine, taurine + caffeine + phosphatidylserine 300 mg, and taurine + caffeine + phosphatidylserine 600 mg. Importantly, caffeine and taurine doses will remain identical across all active supplementation groups in order to enable a more precise evaluation of the independent effects of phosphatidylserine.

Participants will complete a 14-day supplementation protocol and undergo baseline and post-intervention assessments including 30 m sprint performance, reaction time, cognitive-fatigue responses, football-specific GPS monitoring, fatigue-related performance decline, recovery-related variables, sleep monitoring, and autonomic nervous system activity assessment.

The study is expected to provide novel insights into the role of phosphatidylserine in football-specific performance, cognitive fatigue resistance, recovery, and neurophysiological responses in elite football players.

Tipo di studio

Interventistico

Iscrizione (Effettivo)

97

Fase

  • Non applicabile

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

  • Polonia
      • Lodz, Polonia
        • Professional Football Training Center
      • Warsaw, Polonia
        • Professional Football Training Center
      • Wroclaw, Polonia
        • Professional Football Training Center
  • Spagna
      • Alicante, Spagna
        • Professional Football Training Center
  • Ungheria
      • Budapest, Ungheria
        • Professional Football Training Center

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

  • Adulto

Accetta volontari sani

Sì

Descrizione

Inclusion Criteria:

-

Inclusion Criteria:

  • Professional male football players aged 18-35 years
  • Regular participation in team training and competitive matches
  • Clinically healthy status confirmed prior to participation
  • Written informed consent provided

Exclusion Criteria:

  • Current musculoskeletal injury or illness
  • Chronic metabolic, cardiovascular, or neurological disease
  • Regular medication use
  • Current use of dietary supplements or ergogenic aids
  • Smoking or excessive alcohol consumption
  • Known hypersensitivity to any study supplement ingredient

Exclusion Criteria:

-

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Altro
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Triplicare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Comparatore placebo: P
Participants will receive visually identical placebo capsules for 14 days.
Altro: Placebo
Placebo capsules administered daily during the 14-day intervention period
Sperimentale: TC
Participants will receive taurine (1500 mg/day) and caffeine (200 mg/day) supplementation for 14 days.
Integratore alimentare: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Integratore alimentare: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Sperimentale: TCP-300
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (300 mg/day) supplementation for 14 days.
Integratore alimentare: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Integratore alimentare: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Integratore alimentare: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.
Sperimentale: TCP-600
Participants will receive taurine (1500 mg/day), caffeine (200 mg/day), and phosphatidylserine (600 mg/day) supplementation for 14 days.
Integratore alimentare: taurine
Taurine supplementation administered daily during the 14-day intervention period.
Integratore alimentare: Caffeine
Caffeine supplementation administered daily during the 14-day intervention period.
Integratore alimentare: Phosphatidylserine
Phosphatidylserine supplementation administered daily during the 14-day intervention period.

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
30 m sprint time
Lasso di tempo: Baseline and after 14 days of supplementation

Time required to complete a 30 m sprint, measured using electronic timing gates. The best result from three maximal sprint trials will be used for analysis.

Unit of Measure: seconds
Baseline and after 14 days of supplementation

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Visual reaction time
Lasso di tempo: Baseline and after 14 days of supplementation
Mean response time to a visual stimulus, measured using a validated visual reaction time test.
Baseline and after 14 days of supplementation
Auditory reaction time
Lasso di tempo: Baseline and after 14 days of supplementation
Mean response time to an auditory stimulus, measured using a computerized auditory reaction time test.
Baseline and after 14 days of supplementation
Total distance covered
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

Total distance covered during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters
After 14 days of supplementation, during the standardized football-specific training session
Relative distance
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

Distance covered per minute during the standardized football-specific training session, measured using a 10-Hz GPS tracking system. Unit of Measure:

meters per minute
After 14 days of supplementation, during the standardized football-specific training session
High-speed running distance
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

Description:

Distance covered at running speeds above 19.8 km/h during the standardized football-specific training session, measured using a 10-Hz GPS tracking system.

Unit of Measure: meters
After 14 days of supplementation, during the standardized football-specific training session
Number of sprints
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

Total number of sprint efforts performed during the standardized football-specific training session. Sprinting will be defined as running speed above 25.0 km/h and measured using a 10-Hz GPS tracking system.

Unit of Measure: number of sprints
After 14 days of supplementation, during the standardized football-specific training session
Player Load
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

External training load during the standardized football-specific training session, measured using triaxial accelerometry integrated with the GPS tracking system.

Unit of Measure: arbitrary units
After 14 days of supplementation, during the standardized football-specific training session
Heart rate variability RMSSD
Lasso di tempo: Daily during the 14-day supplementation period
Resting heart rate variability assessed in the morning using the root mean square of successive differences between normal heartbeats. HRV will be measured using a heart rate sensor or wearable device under standardized resting conditions. Unit of Measure: milliseconds
Daily during the 14-day supplementation period
Sleep duration
Lasso di tempo: Daily during the 14-day supplementation period
Total sleep duration assessed using wearable sleep monitoring. Unit of Measure: hours
Daily during the 14-day supplementation period
Sleep efficiency
Lasso di tempo: Daily during the 14-day supplementation period

Percentage of time in bed spent asleep, assessed using wearable sleep monitoring.

Unit of Measure: percent
Daily during the 14-day supplementation period
Subjective fatigue
Lasso di tempo: Daily during the 14-day supplementation period
Subjective fatigue assessed using the fatigue item of the Hooper Index questionnaire on a 1-7 scale, where higher values indicate greater fatigue. Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Muscle soreness
Lasso di tempo: Daily during the 14-day supplementation period

Perceived lower-limb muscle soreness assessed using a 0-10 delayed onset muscle soreness scale, where higher values indicate greater soreness.

Unit of Measure: score on a scale
Daily during the 14-day supplementation period
Stroop task reaction time
Lasso di tempo: Baseline and after 14 days of supplementation
Mean response time during a modified computerized Stroop task assessing cognitive fatigue, inhibitory control, sustained attention, and information processing speed. Unit of Measure: seconds
Baseline and after 14 days of supplementation
Stroop task accuracy
Lasso di tempo: Baseline and after 14 days of supplementation
Percentage of correct responses during a modified computerized Stroop task. Unit of Measure: percent
Baseline and after 14 days of supplementation
Stroop task error rate
Lasso di tempo: Baseline and after 14 days of supplementation
Number of incorrect responses during a modified computerized Stroop task. Unit of Measure: number of errors
Baseline and after 14 days of supplementation
Perceived mental fatigue
Lasso di tempo: Baseline and after 14 days of supplementation
Subjective perceived mental fatigue assessed using a 0-10 visual analogue scale, where higher values indicate greater perceived mental fatigue. Unit of Measure: score on a 0-10 scale
Baseline and after 14 days of supplementation
Change in sprint count between first and second half
Lasso di tempo: After 14 days of supplementation, during the standardized football-specific training session

Percentage decline in the number of sprints between the first and second half of the standardized football-specific training session. Sprint change will be calculated as: [(second half value - first half value) / first half value] × 100.

Unit of Measure: percent
After 14 days of supplementation, during the standardized football-specific training session

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Vizja University in Warsaw

Investigatori

  • Investigatore principale: Krzysztof Maciej MIZERA, PhD, 1. Vizja University in Warsaw, Faculty of Medical Sciences and Health Sciences, 01-143 Warsaw, Poland

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

14 giugno 2026

Completamento primario (Effettivo)

30 giugno 2026

Completamento dello studio (Effettivo)

30 giugno 2026

Date di iscrizione allo studio

Primo inviato

13 maggio 2026

Primo inviato che soddisfa i criteri di controllo qualità

17 maggio 2026

Primo Inserito (Effettivo)

22 maggio 2026

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

2 luglio 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

30 giugno 2026

Ultimo verificato

1 giugno 2026

Maggiori informazioni

Termini relativi a questo studio

Parole chiave

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • MIZERA-FOOTBALL-2026

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

INDECISO

Descrizione del piano IPD

Data sharing plans have not yet been finalized.

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

No

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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