Stanford University Microbiome Bank (SUMB)

Inclusion Criteria:

• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for the duration of the study
• Any person aged 18-80 years of age, inclusive at the time of signing the consent
• In good general health as evidenced by medical history
• Ability to travel to donation facility on a weekly basis
• Residence within 5 miles of Stanford Campus
• For females of reproductive potential: use of highly effective contraception for at least 1 month prior to screening and agreement to use such a method during study participation
• Capable of providing signed informed consent.

Exclusion Criteria:

• Inflammatory bowel disease
• Enteric infections
• Previous infection with Clostridium difficile
• History of gastrointestinal surgery: Participants with gastrointestinal surgeries below the pylorus will be excluded from this protocol, including participants with a history of colectomy, segmental colonic resection, and small bowel resections.
• Documented severe gastroparesis
• Active intestinal obstruction
• Dysphagia (oropharyngeal, esophageal, functional or neuromuscular)
• History or current malignancy diagnosis
• History of recurrent aspiration episodes
• Any conditions associated with a high risk of bleeding, including but not limited to coagulopathy/bleeding disorder, severe liver disease, active or recent GI bleeding, or recent abdominal or other GI surgery
• Active diagnosis of major depressive disorder
• Active diagnosis of major anxiety disorder
• Severe immunodeficiency, inherited or acquired (e.g., Human immunodeficiency virus, active chemotherapy or immunosuppressive medications [including steroids, biologic therapy, or bone marrow suppressive agents], or radiation therapy)
• BMI of less than 18 or BMI greater than 30
• Record of eating disorders
• Active use of GLP-1 inhibitors
• Diagnosis of Human immunodeficiency virus infection; Hepatitis A, B, C & E; Epstein Bar Virus; parasitic infections; Syphilis
• Pregnancy & lactation
• Active drug, or alcohol use disorder
• Tobacco, marijuana and e-cigarette use
• Any other significant medical condition that could confound or interfere with evaluation of safety or tolerability or prevent compliance with the study protocol at the discretion of the Investigator

Prior/concomitant therapy

• Active antibiotic use
• Active treatment with high levels of immunosuppressive therapies (active chemotherapy or immunosuppressive medications [including steroids, biologic therapy, or bone marrow suppressive agent], or radiation therapy)
• Simultaneous participation in another interventional clinical trial

Other exclusion criteria

-Inability to comply with research requirements