Role of Fat Tissue in Vitamin D Metabolism

The Role of Adipose Tissue in Vitamin D Metabolism


Patrocinador principal: Tufts University

Colaborador: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Fuente Tufts University
Resumen breve

Vitamin D is a fat soluble vitamin that has important effects on calcium (including absorption of calcium from the diet) and bone metabolism. Vitamin D is known to be stored in fat tissue, and it is also present in the circulation. The purpose of this study is to investigate the relationship between levels of vitamin D in fat tissue and in blood.

Descripción detallada

Although vitamin D is known to be stored in fat tissue, researchers are not sure about the role that fat tissue plays in vitamin D metabolism. This study will help develop the methodology necessary to further investigate the role of fat tissue in vitamin D metabolism and will assess the relationship between levels of vitamin D in fat tissue and in blood. 50 subjects who are referred for gastric bypass surgery will be enrolled in this study. Subjects will complete questionnaires about their medical history, travel history and food intake. Prior to or during surgery, subjects will be asked to provide a blood sample for selected chemistries related to vitamin D metabolism. During gastric bypass surgery, the surgeon will collect small pieces of fat tissue from the fat under the skin and within the abdomen by surgical biopsy. These samples will be used to refine the methodology for determining the levels of vitamin D in blood and fat tissue and for comparing levels of vitamin D in various tissues.

Estado general Completed
Fecha de inicio April 2002
Fecha de Terminación September 2007
Fecha de finalización primaria September 2007
Tipo de estudio Observational
Inscripción 41

Método de muestreo: Non-Probability Sample


Inclusion Criteria:

- Obese patients referred for gastric bypass surgery

Exclusion Criteria:

- Patients must not be taking bile acid-sequestering medications or anti-seizure medications

Género: All

Edad mínima: 18 Years

Edad máxima: 65 Years

Voluntarios Saludables: No

Oficial general
Apellido Papel Afiliación
Miriam Blum, MD Principal Investigator Jean Mayer USDA Human Nutrition Center on Aging at Tufts University
Instalaciones: Tufts-New England Medical Center
Ubicacion Paises

United States

Fecha de verificación

May 2013

Fiesta responsable

Nombre Titulo: Miriam Blum, MD

Organización: HNRC at Tufts

Palabras clave
Tiene acceso ampliado No
Información de diseño del estudio

Modelo de observación: Case-Only

Perspectiva de tiempo: Cross-Sectional