Effects of REnal Denervation for Resistant Hypertension on Exercise Diastolic Function and Regression of Atherosclerosis and the Evaluation of NEW Methods Predicting A successfuL Renal Sympathetic Denervation (RENEWAL-EXERCISE, -REGRESS, and -PREDICT Trial From RENEWAL RDN Registry)

Inclusion Criteria:

• Patients aged 20-85 years with resistant hypertension defined as systolic BP>140 mmHg (>130 mmHg for diabetes) or diastolic BP>90mmHg (>80 mmHg for diabetes) despite adequate administration of 3 or more different classes of anti-hypertensive medications including diuretics with good adherence and adequate treatment regimen.
• All agents should be prescribed at optimal dose amounts. BP was based on an average of 3 office BP readings measured according to the general guidelines. Patients are adhering to a stable drug regimen including 3 or more antihypertensive medications (with no changes for a minimum of 2 weeks prior to enrollment).
• Patients provided with the written, informed consent to participate in this study

Exclusion Criteria:

• Hemodynamically or anatomically significant renal artery abnormalities, main renal arteries < 4 mm in diameter or < 20 mm in length, or.prior renal artery intervention
• Estimated glomerular filtration rate (eGFR) of < 30mL/min/1.73m2, using the MDRD calculation
• Hemodynamically significant valvular heart disease
• History of congestive heart failure with reduce LV ejection fraction of less than 35%
• CVA in the prior 3 months
• ST-segment elevation MI within 48 hours
• Scheduled or planned surgery or cardiovascular intervention in the next 6 months.
• Patients with chronic debilitating disease with life expectancy of less than 1 year
• Patients taking hormone replace treatment and/or oral contraceptives; pregnant, nursing or planning to be pregnant
• Chronic liver cirrhosis