The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses
Descripción general del estudio
Descripción detallada
Rationale:
There is very little evidence at the present time in the role of food structure in glucose homeostasis. There is circumstantial evidence that foods consumed intact have great effects on suppressing appetite.
To test the effect of three structurally different meals with the same nutritional content and volume on appetite regulation. Each participant will receive the following meals:
Solid meal group. Milled (intact-cell) meal group. Milled (destroyed-cell) meal group.
All of which will contain the same macro and micro nutrients from the same food sources
Tipo de estudio
Inscripción (Actual)
Fase
- No aplica
Criterios de participación
Criterio de elegibilidad
Edades elegibles para estudiar
Acepta Voluntarios Saludables
Géneros elegibles para el estudio
Descripción
Inclusion Criteria:
- Gender: male and female
- Age ≥ 18 years ≤ 65 years
- Normal weight as classified by BMI 20-29.9 kg/m2
- Healthy, not diagnosed with any chronic diseases assessed as appropriate for inclusion, based on the pre-study screening.
- Willingness and ability to understand, participate and to comply with the study requirements
- Willingness and ability to give written informed consent
Exclusion Criteria:
- Has thyroid defects
- Under hormone or steroids therapy
- Is pregnant or lactating (female)
- Had given birth within the past year (female)
- Is taking drugs that could affect appetite or plasma glucose levels.
- Is taking natural remedies that modulate appetite or plasma glucose levels.
- Has excessive alcohol intake
- Had blood donation within 12wks prior to start date
- Psychiatric illness
- Smokers
- History of any disease with unknown outcome
- Has diabetes
- Has nut allergy
Plan de estudios
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Prevención
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación cruzada
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Experimental: whole chickpea
a test meal containing 26g available carbohydrates from chickpea (full structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
|
Experimental: flour chickpea
a test meal containing 26g available carbohydrates from flour chickpea (destroyed structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
|
Experimental: intact cell chickpea
a test meal containing 26g available carbohydrates from intact cell chickpea flour (full structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Post-prandial Glucose Concentrations
Periodo de tiempo: before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.
|
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus |
before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.
|
|
Post-prandial Blood Insulin Concentrations
Periodo de tiempo: before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.
|
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus.
Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.
|
before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Post-prandial Gut Hormone Gastric Inhibitory Polypeptide (GIP)
Periodo de tiempo: before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.
|
Blood GIP concentrations were assessed for each participant after each test meal: whole chickpea hummus, and Flour chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus |
before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.
|
|
Post-prandial Gut Hormone Glucagon-like Peptide 1 (GLP-1)
Periodo de tiempo: baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.
|
Blood GLP-1 concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus.
Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.
|
baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.
|
|
Energy Intake at a Meal Given in Excess
Periodo de tiempo: post consumption of the test meal at 120 minutes
|
The difference in ad libitum food intake after 210 minutes post test meal to test the difference of energy intake following whole chickpea hummus, flour chickpea hummus, and intact cell chickpea hummus.
|
post consumption of the test meal at 120 minutes
|
Colaboradores e Investigadores
Patrocinador
Fechas de registro del estudio
Fechas importantes del estudio
Inicio del estudio (Actual)
Finalización primaria (Actual)
Finalización del estudio (Actual)
Fechas de registro del estudio
Enviado por primera vez
Primero enviado que cumplió con los criterios de control de calidad
Publicado por primera vez (Actual)
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
Última actualización enviada que cumplió con los criterios de control de calidad
Última verificación
Más información
Términos relacionados con este estudio
Otros números de identificación del estudio
- 15HH3069
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