The Acute Effects of Food Structure on Post Prandial Glucose and Subsequent Metabolic Responses
Обзор исследования
Подробное описание
Rationale:
There is very little evidence at the present time in the role of food structure in glucose homeostasis. There is circumstantial evidence that foods consumed intact have great effects on suppressing appetite.
To test the effect of three structurally different meals with the same nutritional content and volume on appetite regulation. Each participant will receive the following meals:
Solid meal group. Milled (intact-cell) meal group. Milled (destroyed-cell) meal group.
All of which will contain the same macro and micro nutrients from the same food sources
Тип исследования
Регистрация (Действительный)
Фаза
- Непригодный
Критерии участия
Критерии приемлемости
Возраст, подходящий для обучения
Принимает здоровых добровольцев
Полы, имеющие право на обучение
Описание
Inclusion Criteria:
- Gender: male and female
- Age ≥ 18 years ≤ 65 years
- Normal weight as classified by BMI 20-29.9 kg/m2
- Healthy, not diagnosed with any chronic diseases assessed as appropriate for inclusion, based on the pre-study screening.
- Willingness and ability to understand, participate and to comply with the study requirements
- Willingness and ability to give written informed consent
Exclusion Criteria:
- Has thyroid defects
- Under hormone or steroids therapy
- Is pregnant or lactating (female)
- Had given birth within the past year (female)
- Is taking drugs that could affect appetite or plasma glucose levels.
- Is taking natural remedies that modulate appetite or plasma glucose levels.
- Has excessive alcohol intake
- Had blood donation within 12wks prior to start date
- Psychiatric illness
- Smokers
- History of any disease with unknown outcome
- Has diabetes
- Has nut allergy
Учебный план
Как устроено исследование?
Детали дизайна
- Основная цель: Профилактика
- Распределение: Рандомизированный
- Интервенционная модель: Назначение кроссовера
- Маскировка: Одинокий
Оружие и интервенции
Группа участников / Армия |
Вмешательство/лечение |
|---|---|
|
Экспериментальный: whole chickpea
a test meal containing 26g available carbohydrates from chickpea (full structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
|
Экспериментальный: flour chickpea
a test meal containing 26g available carbohydrates from flour chickpea (destroyed structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
|
Экспериментальный: intact cell chickpea
a test meal containing 26g available carbohydrates from intact cell chickpea flour (full structure)
|
all three meals are isocaloric but different in the chickpea structure( physical form): • Whole chickpea, flour chickpea, intact cell flour chickpea |
Что измеряет исследование?
Первичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
|
Post-prandial Glucose Concentrations
Временное ограничение: before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.
|
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus |
before the consumption of the test meal and then 15 min, 30, 60,90, 120, 180 minutes after the consumption of the test meal.
|
|
Post-prandial Blood Insulin Concentrations
Временное ограничение: before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.
|
Blood glucose concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus.
Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.
|
before the consumption of the test meal and then 15, 30, 60, 90, 120, and 180 minutes post consumption of test meal.
|
Вторичные показатели результатов
Мера результата |
Мера Описание |
Временное ограничение |
|---|---|---|
|
Post-prandial Gut Hormone Gastric Inhibitory Polypeptide (GIP)
Временное ограничение: before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.
|
Blood GIP concentrations were assessed for each participant after each test meal: whole chickpea hummus, and Flour chickpea hummus. Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal. Data were not collected for intact cell chickpea hummus |
before the consumption of the test meal at 0 min and then post test meal at 15, 30,60 ,90,120 and 180 minutes.
|
|
Post-prandial Gut Hormone Glucagon-like Peptide 1 (GLP-1)
Временное ограничение: baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.
|
Blood GLP-1 concentrations were assessed for each participant after each test meal: whole chickpea hummus, Flour chickpea hummus, and Intact cell chickpea hummus.
Blood samples were collected before the introduction of the test meal and then at 15 minutes, 30 min, 60, 90, 120, and 180 minutes after the consumption of the test meal.
|
baseline before the consumption of the test meal, and then 15,30,60,90,120,180 min after the consumption of the test meal.
|
|
Energy Intake at a Meal Given in Excess
Временное ограничение: post consumption of the test meal at 120 minutes
|
The difference in ad libitum food intake after 210 minutes post test meal to test the difference of energy intake following whole chickpea hummus, flour chickpea hummus, and intact cell chickpea hummus.
|
post consumption of the test meal at 120 minutes
|
Соавторы и исследователи
Спонсор
Даты записи исследования
Изучение основных дат
Начало исследования (Действительный)
Первичное завершение (Действительный)
Завершение исследования (Действительный)
Даты регистрации исследования
Первый отправленный
Впервые представлено, что соответствует критериям контроля качества
Первый опубликованный (Действительный)
Обновления учебных записей
Последнее опубликованное обновление (Действительный)
Последнее отправленное обновление, отвечающее критериям контроля качества
Последняя проверка
Дополнительная информация
Термины, связанные с этим исследованием
Другие идентификационные номера исследования
- 15HH3069
Эта информация была получена непосредственно с веб-сайта clinicaltrials.gov без каких-либо изменений. Если у вас есть запросы на изменение, удаление или обновление сведений об исследовании, обращайтесь по адресу register@clinicaltrials.gov. Как только изменение будет реализовано на clinicaltrials.gov, оно будет автоматически обновлено и на нашем веб-сайте. .