Mesenchymal Stem Cells in the Treatment of Burn Wounds

Inclusion Criteria:

1. Voluntary participation and signing of the informed consent form;
2. Burn patients, subjects requiring autologous skin grafting;
3. Age 18 to 65 years old, gender not restricted;
4. During this clinical study, single person, single donor skin area (lateral thigh or trunk) treatment;
5. Skin burn area < 30% of total body surface area (TBSA);
6. The donor skin area is the first time for donation, and the donor skin area is medium-thick skin (thickness approximately 0.4mm);
7. The area of the excised skin flap ≥ 90 cm2;
8. Able to cooperate with this study protocol and accept regular postoperative follow-up visits.

Exclusion Criteria:

1. Those allergic to sodium alginate (gel component);
2. Electric shock injuries, chemical burns, radiation injuries or combined with other traumas;
3. Subjects with severe systemic diseases (judged by the researchers);
4. Subjects with uncontrolled hypertension or diabetes (judged by the researchers);
5. Pregnant or lactating women;
6. Subjects whose condition may affect the study assessment or require the concurrent use of medical treatments that may affect the efficacy assessment;
7. Subjects with acute or chronic kidney diseases, renal failure or serum creatinine level = 1.5 times the upper limit of normal value;
8. Subjects with acute or chronic liver diseases, total bilirubin, alanine aminotransferase, aspartate aminotransferase = 2.0 times the upper limit of normal value;
9. Subjects with a history of malignant tumors;
10. Subjects who have participated in other clinical studies for less than 3 months;
11. Subjects with mental disorders and without self-awareness, unable to express clearly;
12. Subjects using immunosuppressants and those who have been using corticosteroids for a long time (more than 1 month) (excluding local application);
13. Subjects with infectious diseases (any one of the four items positive in the test);
14. Subjects with other severe systemic diseases;
15. Other subjects that the researchers consider not eligible for inclusion.