Effects of cerebral near-infrared spectroscopy on the outcome of patients undergoing cardiac surgery: a systematic review of randomised trials

Giuseppe Filiberto Serraino, Gavin J Murphy, Giuseppe Filiberto Serraino, Gavin J Murphy

Abstract

Objectives: Goal-directed optimisation of cerebral oxygenation using near-infrared spectroscopy (NIRS) during cardiopulmonary bypass is widely used. We tested the hypotheses that the use of NIRS cerebral oximetry results in reductions in cerebral injury (neurocognitive function, serum biomarkers), injury to other organs including the heart and brain, transfusion rates, mortality and resource use.

Design: Systematic review and meta-analysis.

Setting: Tertiary cardiac surgery centres in North America, Europe and Asia.

Participants: A search of Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Medline, Embase, and the Cumulative Index to Nursing and Allied Health Literature Plus from inception to November 2016 identified 10 randomised trials, enrolling a total of 1466 patients, all in adult cardiac surgery.

Interventions: NIRS-based algorithms designed to optimise cerebral oxygenation versus standard care (non-NIRS-based) protocols in cardiac surgery patients during cardiopulmonary bypass.

Outcome measures: Mortality, organ injury affecting the brain, heart and kidneys, red cell transfusion and resource use.

Results: Two of the 10 trials identified in the literature search were considered at low risk of bias. Random-effects meta-analysis demonstrated similar mortality (risk ratio (RR) 0.76, 95% CI 0.30 to 1.96), major morbidity including stroke (RR 1. 08, 95% CI 0.40 to 2.91), red cell transfusion and resource use in NIRS-treated patients and controls, with little or no heterogeneity. Grades of Recommendation, Assessment, Development and Evaluation of the quality of the evidence was low or very low for all of the outcomes assessed.

Conclusions: The results of this systematic review did not support the hypotheses that cerebral NIRS-based algorithms have clinical benefits in cardiac surgery.

Trial registration number: PROSPERO CRD42015027696.

Keywords: cardiopulmonary bypass; cerebral oxygenation; near Infra-red spectroscopy.

Conflict of interest statement

Competing interests: GFS declares no conflict of interest. GJM reports grants from British Heart Foundation during the conduct of the study and grants from British Heart Foundation, grants from National Institute for Health Research, grants from Zimmer Biomet, personal fees from AbbVie, and personal fees from Thrasos, outside the submitted work.

© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

Figures

Figure 1
Figure 1
Risk of bias summaries for (A) individual studies and (B) all studies.
Figure 2
Figure 2
Forest plots demonstrating summary effect estimates for (A) mortality, (B) myocardial infarction, (C) stroke and (D) stage 3 acute kidney injury or renal replacement therapy. Effect estimates derived using random-effects meta-analysis. Heterogeneity expressed as χ2and I2. NIRS, near-infrared spectroscopy.

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