Cold Therapy in Migraine Patients: Open-label, Non-controlled, Pilot Study

Serap Ucler, Ozlem Coskun, Levent E Inan, Yonca Kanatli, Serap Ucler, Ozlem Coskun, Levent E Inan, Yonca Kanatli

Abstract

Some patients with headache report that they have frequently used physical therapies such as application of cold to relieve their headache. There are only a few reported studies related to cold therapies in patients with migraine. In this study, we investigated the effect of cold application on migraine patients. Twenty-eight migraine patients were included. Cold therapy was administered to them by gel cap. Patients used this cap during their two migraine attacks. Before and after the cold therapy, headache severity was recorded by using visual analogue scale (VAS). Patients used this cap for 25 min in each application. They recorded their VAS score just after the therapy and 25 min, 1 h, 2 h and 3 h later. Two patients could not use this therapy due to side effects (one due to cold intolerance and one due to vertigo) in both applications. Therefore, therapeutic efficacy was evaluated in 26 patients. Twenty-five minutes after treatment of the first attack, VAS score was decreased from 7.89 +/- 1.93 to 5.54 +/- 2.96 (P < 0.01). Twenty-five minutes after treatment of the second attack, VAS score was decreased from 7.7 +/- 1.8 to 5.4 +/- 3.55 (P < 0.01). Cold application alone may be effective in some patients suffering from migraine attacks. Its combination with conventional drugs should be investigated in future studies.

Figures

Figure 1
Figure 1
The picture of cap used in the study.
Figure 2
Figure 2
VAS scores before and after the treatment of two attacks.
Figure 3
Figure 3
VAS scores before and after the treatment in patients with and without analgesic use.

References

    1. Vijayan N. Head band for migraine headache relief. Headache. 1993;33:40–2.
    1. Edmeads J. Non-pharmacological treatments for headaches. In: Olesen J, Tfelt-Hansen P, Welch KM, editors. The Headaches. 2nd edn. Philadelphia: Lippincott Williams & Wilkins; 2000. pp. 543–4.
    1. Bronfort G, Nilsson N, Haas M, Evans R, Goldsmith CH, Assendelf WJJ, et al. Non-invasive physical treatments for chronic/recurrent headache (Review) Cochrane Database Syst Rev. 2004;3:CD001878.
    1. Tsao JC, Zeltzer LK. Complementary and alternative medicine approaches for pediatric pain: a review of the state-of-the-science. Evid Based Complement Alternat Med. 2005;2:149–59.
    1. Diamond S, Freitag FG. Cold as an adjunctive therapy for headache. Postgrad Med. 1986;79:305–9.
    1. Robbins LD. Cryotherapy for headache. Headache. 1989;29:598–600.
    1. Landy SH, Griffin B. Pressure, heat and cold help relieve headache pain. Arch Fam Med. 2000;9:792–3.
    1. Zanchin G, Maggioni F, Granella F, Rossi P, Falco L, Manzoni GC. Self-administered pain-relieving manoeuvres in primary headaches. Cephalalgia. 2001;21:718–26.
    1. Martins IP, Parreira E. Behavioral response to headache: a comparison between migraine and tension type headache. Headache. 2001;41:546–53.
    1. Bag B, Karabulut N. Pain-relieving factors in migraine and tension-type headache. Int J Clin Pract. 2005;59:760–3.
    1. Friedman MH, Peterson SJ, Behar CF, Zaidi Z. Intraoral chilling versus oral sumatriptan for acute migraine. Heart Dis. 2001;3:357–61.
    1. Lance JW. The controlled application of cold and heat by a new device (Migra-lief apparatus) in the treatment of headache. Headache. 1988;28:458–61.
    1. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988;8:1–96.
    1. Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders. Cephalalgia. (2nd edition) 2004;24:9–160.
    1. Lipton RB, Stewart WF, Sawyer J, Edmeads JG. Clinical utility of an instrument assessing migraine disability: the migraine disability assessment (MIDAS) questionnaire. Headache. 2001;41:854–61.
    1. Stewart WF, Shechter A, Lipton RB. Migraine heterogenity. Disability, pain intensity, and attack frequency and duration. Neurology. 1994;44:24–39.
    1. Rasmussen BK. Epidemiology of headache. Cephalalgia. 1995;15:45–68.
    1. Gedikoglu U, Coskun O, Inan LE, Ucler S, Tunc T, Emre U. Validity and reliability of Turkish translation of migraine disability assessment (MIDAS) questionnaire in patients with migraine. Cephalalgia. 2005;25:452–6.
    1. D'Amico D, Mosconi P, Genco S, Usai S, Prudenzano AMP, Grazzi L, et al. The migraine disability assessment (MIDAS) questionnaire: translation and reliability of the Italian version. Cephalalgia. 2001;21:947–52.
    1. Diamond S. A fresh look at migraine therapy. Postgrad Med. 2001;9:49–59.
    1. Shaikh BT, Hatcher J. Complementary and alternative medicine in Pakistan: prospects and limitations. Evid Based Complement Alternat Med. 2005;2:139–42.
    1. Capodice JL, Bemis DL, Buttyan R, Kaplan SA, Katz AE. Complementary and alternative medicine for chronic prostatitis/chronic pelvic pain syndrome. Evid Based Complement Alternat Med. 2005;2:495–501.
    1. Sauls J. The use of ice for pain associated with chest tube removal. Pain Manag Nurs. 2002;3:44–52.
    1. Loder E, Goldstein R, Biondi D. Placebo effects in oral triptan trials: the scientific and ethical rationale for continued use of placebo controls. Cephalalgia. 2005;25:124–31.

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