CKD in Hispanics: Baseline characteristics from the CRIC (Chronic Renal Insufficiency Cohort) and Hispanic-CRIC Studies
Michael J Fischer, Alan S Go, Claudia M Lora, Lynn Ackerson, Janet Cohan, John W Kusek, Alejandro Mercado, Akinlolu Ojo, Ana C Ricardo, Leigh K Rosen, Kaixiang Tao, Dawei Xie, Harold I Feldman, James P Lash, CRIC and H-CRIC Study Groups, Harold I Feldman, J Richard Landis, Dina H Appleby, Shawn Ballard, Denise Cifelli, Robert M Curley, Jennifer Dickson, Marie Durborow, Stephen Durborow, Melanie Glenn, Asaf Hanish, Christopher Helker, Elizabeth S Helker, Amanda Hyre Anderson, Marshall Joffe, Scott Kasner, Stephen E Kimmel, Shiriki Kumanyika, Lisa Nessel, Emile R Mohler 3rd, Steven R Messe, Nancy Robinson, Leigh Rosen, J Sanford Schwartz, Sandra Smith, Joan Stahl, Kelvin Tao, Valerie L Teal, Xin Wang, Dawei Xie, Peter Yang, Xiaoming Zhang, Raymond R Townsend, Manjunath Balaram, Thomas P Cappola, Debbie Cohen, Magdalena Cuevas, Mark J Duckworth, Daniel L Dries, Virginia Ford, Colin M Gorman, Juan Grunwald, Holly M Hannah, Peter A Kanetsky, Krishna Kellem, Lucy Kibe, Mary B Leonard, Maureen Maguire, Stephanie McDowell, John Murphy, Muredach Reilly, Sylvia E Rosas, Wanda M Seamon, Angie Sheridan, Karen Teff, Lawrence J Appel, Cheryl Anderson, Jeanne Charleston, Nyya Etheredge, Bernard Jaar, Kelly Mantegna, Carla Martin, Edgar Miller, Patience Ngoh, Julia Scialla, Steve Sozio, Sharon Turban, Hemalatha Venkatesh, Jeffrey Fink, Wanda Fink, Afshin Parsa, Beth Scism, Stephen Seliger, Matthew Weir, Mahboob Rahman, Valori Corrigan, Renee Dancie, Genya Kisin, Radhika Kanthety, Louise Strauss, Jackson T Wright Jr, Jeffrey Schelling, Patricia Kao, Ed Horowitz, Jacqui Bjaloncik, Theresa Fallon, John R Sedor, Mary Ann Shella, Jacqueline Theurer, J Daryl Thornton, Martin J Schreiber, Martha Coleman, Richard Fatica, Sandra Halliburton, Carol Horner, Teresa Markle, Mohammed A Rafey, Annette Russo, Stephanie Slattery, Rita Spirko, Kay Stelmach, Velma Stephens, Lara Danziger-Isakov, Akinlolu Ojo, Baskaran Sundaram, Jeff Briesmiester, Denise Cornish- Zirker, Crystal Gadegbeku, Nancy Hill, Kenneth Jamerson, Matthias Kretzler, Bruce Robinson, Rajiv Saran, Bonnie Welliver, Jillian Wilson, Eric Young, Susan P Steigerwalt, Keith Bellovich, Jennifer DeLuca, Sherry Gasko, Gail Makos, Chantal Parmelee, Shahan Smith, Kathleen Walls, John M Flack, James Sondheimer, Mary Maysura, Stephen Migdal, M Jena Mohanty, Yanni Zhuang, James P Lash, Jose Arruda, Carolyn Brecklin, Eunice Carmona, Janet Cohan, Michael Fischer, Anne Frydrych, Amada Lopez, Claudia Lora, Monica Martinez, Adriana Matos, Alejandro Mercado, Brenda Moreno, Patricia Meslar, Ana Ricardo, Thomas Stamos, Eve Van Cauter, Jiang He, Brent Alper, Vecihi Batuman, Lydia A Bazzano, Bernadette Borja, Adriana Burridge, Jing Chen, Catherine Cooke, Patrice Delafontaine, Karen B DeSalvo, Vivian A Fonseca, Lee Hamm, Michelle R Hurly, Julie Legarde, Eva Lustigova, Paul Muntner, Maria Patrocollo-Emerson, Shea Shelton, Claire Starcke, Paul Whelton, Alan S Go, Lynn M Ackerson, Pete Dorin, Daniel Fernandez, Nancy G Jensvold, Joan C Lo, Juan D Ordonez, Rachel Perloff, Thida Tan, Daphne Thompson, Gina M Valladares, Annette Wiggins, Diana B Wong, Jingrong Yang, Chi-yuan Hsu, Glenn M Chertow, Nisha Bansal, Manju Kurella, Michael G Shlipak, Kristine Yaffe, John W Kusek, Andrew S Narva, Kathy Faber-Langendoen, Bryce A Kiberd, Elisa T Lee, Julia Lewis, William McClellan, Timothy Meyer, David Nathan, John B Stokes, Herman Taylor, Peter W Wilson, Vallabh Shah, Dominic Raj, Myles Wolf, Paul M Ridker, Daniel J Rader, Anna DiFlorio, Ted Mifflin, Linda Morrell, Megan L Wolfe, Phillip Hall, Henry Rolin, Sue Saunders, Mathew Budoff, Chris Dailing, Elsayed Z Soliman, Zhu- Ming Zhang, Martin St John Sutton, Martin G Keane, Michael J Fischer, Alan S Go, Claudia M Lora, Lynn Ackerson, Janet Cohan, John W Kusek, Alejandro Mercado, Akinlolu Ojo, Ana C Ricardo, Leigh K Rosen, Kaixiang Tao, Dawei Xie, Harold I Feldman, James P Lash, CRIC and H-CRIC Study Groups, Harold I Feldman, J Richard Landis, Dina H Appleby, Shawn Ballard, Denise Cifelli, Robert M Curley, Jennifer Dickson, Marie Durborow, Stephen Durborow, Melanie Glenn, Asaf Hanish, Christopher Helker, Elizabeth S Helker, Amanda Hyre Anderson, Marshall Joffe, Scott Kasner, Stephen E Kimmel, Shiriki Kumanyika, Lisa Nessel, Emile R Mohler 3rd, Steven R Messe, Nancy Robinson, Leigh Rosen, J Sanford Schwartz, Sandra Smith, Joan Stahl, Kelvin Tao, Valerie L Teal, Xin Wang, Dawei Xie, Peter Yang, Xiaoming Zhang, Raymond R Townsend, Manjunath Balaram, Thomas P Cappola, Debbie Cohen, Magdalena Cuevas, Mark J Duckworth, Daniel L Dries, Virginia Ford, Colin M Gorman, Juan Grunwald, Holly M Hannah, Peter A Kanetsky, Krishna Kellem, Lucy Kibe, Mary B Leonard, Maureen Maguire, Stephanie McDowell, John Murphy, Muredach Reilly, Sylvia E Rosas, Wanda M Seamon, Angie Sheridan, Karen Teff, Lawrence J Appel, Cheryl Anderson, Jeanne Charleston, Nyya Etheredge, Bernard Jaar, Kelly Mantegna, Carla Martin, Edgar Miller, Patience Ngoh, Julia Scialla, Steve Sozio, Sharon Turban, Hemalatha Venkatesh, Jeffrey Fink, Wanda Fink, Afshin Parsa, Beth Scism, Stephen Seliger, Matthew Weir, Mahboob Rahman, Valori Corrigan, Renee Dancie, Genya Kisin, Radhika Kanthety, Louise Strauss, Jackson T Wright Jr, Jeffrey Schelling, Patricia Kao, Ed Horowitz, Jacqui Bjaloncik, Theresa Fallon, John R Sedor, Mary Ann Shella, Jacqueline Theurer, J Daryl Thornton, Martin J Schreiber, Martha Coleman, Richard Fatica, Sandra Halliburton, Carol Horner, Teresa Markle, Mohammed A Rafey, Annette Russo, Stephanie Slattery, Rita Spirko, Kay Stelmach, Velma Stephens, Lara Danziger-Isakov, Akinlolu Ojo, Baskaran Sundaram, Jeff Briesmiester, Denise Cornish- Zirker, Crystal Gadegbeku, Nancy Hill, Kenneth Jamerson, Matthias Kretzler, Bruce Robinson, Rajiv Saran, Bonnie Welliver, Jillian Wilson, Eric Young, Susan P Steigerwalt, Keith Bellovich, Jennifer DeLuca, Sherry Gasko, Gail Makos, Chantal Parmelee, Shahan Smith, Kathleen Walls, John M Flack, James Sondheimer, Mary Maysura, Stephen Migdal, M Jena Mohanty, Yanni Zhuang, James P Lash, Jose Arruda, Carolyn Brecklin, Eunice Carmona, Janet Cohan, Michael Fischer, Anne Frydrych, Amada Lopez, Claudia Lora, Monica Martinez, Adriana Matos, Alejandro Mercado, Brenda Moreno, Patricia Meslar, Ana Ricardo, Thomas Stamos, Eve Van Cauter, Jiang He, Brent Alper, Vecihi Batuman, Lydia A Bazzano, Bernadette Borja, Adriana Burridge, Jing Chen, Catherine Cooke, Patrice Delafontaine, Karen B DeSalvo, Vivian A Fonseca, Lee Hamm, Michelle R Hurly, Julie Legarde, Eva Lustigova, Paul Muntner, Maria Patrocollo-Emerson, Shea Shelton, Claire Starcke, Paul Whelton, Alan S Go, Lynn M Ackerson, Pete Dorin, Daniel Fernandez, Nancy G Jensvold, Joan C Lo, Juan D Ordonez, Rachel Perloff, Thida Tan, Daphne Thompson, Gina M Valladares, Annette Wiggins, Diana B Wong, Jingrong Yang, Chi-yuan Hsu, Glenn M Chertow, Nisha Bansal, Manju Kurella, Michael G Shlipak, Kristine Yaffe, John W Kusek, Andrew S Narva, Kathy Faber-Langendoen, Bryce A Kiberd, Elisa T Lee, Julia Lewis, William McClellan, Timothy Meyer, David Nathan, John B Stokes, Herman Taylor, Peter W Wilson, Vallabh Shah, Dominic Raj, Myles Wolf, Paul M Ridker, Daniel J Rader, Anna DiFlorio, Ted Mifflin, Linda Morrell, Megan L Wolfe, Phillip Hall, Henry Rolin, Sue Saunders, Mathew Budoff, Chris Dailing, Elsayed Z Soliman, Zhu- Ming Zhang, Martin St John Sutton, Martin G Keane
Abstract
Background: Little is known regarding chronic kidney disease (CKD) in Hispanics. We compared baseline characteristics of Hispanic participants in the Chronic Renal Insufficiency Cohort (CRIC) and Hispanic-CRIC (H-CRIC) Studies with non-Hispanic CRIC participants.
Study design: Cross-sectional analysis.
Setting & participants: Participants were aged 21-74 years with CKD using age-based estimated glomerular filtration rate (eGFR) at enrollment into the CRIC/H-CRIC Studies. H-CRIC included Hispanics recruited at the University of Illinois in 2005-2008, whereas CRIC included Hispanics and non-Hispanics recruited at 7 clinical centers in 2003-2007.
Factor: Race/ethnicity.
Outcomes: Blood pressure, angiotensin-converting enzyme (ACE)-inhibitor/angiotensin receptor blocker (ARB) use, and CKD-associated complications.
Measurements: Demographic characteristics, laboratory data, blood pressure, and medications were assessed using standard techniques and protocols.
Results: Of H-CRIC/CRIC participants, 497 were Hispanic, 1,650 were non-Hispanic black, and 1,638 were non-Hispanic white. Low income and educational attainment were nearly twice as prevalent in Hispanics compared with non-Hispanics (P < 0.01). Hispanics had self-reported diabetes (67%) more frequently than non-Hispanic blacks (51%) and whites (40%; P < 0.01). Blood pressure >130/80 mm Hg was more common in Hispanics (62%) than blacks (57%) and whites (35%; P < 0.05), and abnormalities in hematologic, metabolic, and bone metabolism parameters were more prevalent in Hispanics (P < 0.05), even after stratifying by entry eGFR. Hispanics had the lowest use of ACE inhibitors/ARBs among the high-risk subgroups, including participants with diabetes, proteinuria, and blood pressure >130/80 mm Hg. Mean eGFR was lower in Hispanics (39.6 mL/min/1.73 m(2)) than in blacks (43.7 mL/min/1.73 m(2)) and whites (46.2 mL/min/1.73 m(2)), whereas median proteinuria was higher in Hispanics (protein excretion, 0.72 g/d) than in blacks (0.24 g/d) and whites (0.12 g/d; P < 0.01).
Limitations: Generalizability; observed associations limited by residual bias and confounding.
Conclusions: Hispanics with CKD in the CRIC/H-CRIC Studies are disproportionately burdened with lower socioeconomic status, more frequent diabetes mellitus, less ACE-inhibitor/ARB use, worse blood pressure control, and more severe CKD and associated complications than their non-Hispanic counterparts.
Published by Elsevier Inc.
Source: PubMed