Association between parental history of diabetes and type 2 diabetes genetic risk scores in the PPP-Botnia and Framingham Offspring Studies
Jason L Vassy, Peter Shrader, Anna Jonsson, Caroline S Fox, Valeriya Lyssenko, Bo Isomaa, Leif Groop, James B Meigs, Paul W Franks, Jason L Vassy, Peter Shrader, Anna Jonsson, Caroline S Fox, Valeriya Lyssenko, Bo Isomaa, Leif Groop, James B Meigs, Paul W Franks
Abstract
Objective: Parental history of diabetes and specific gene variants are risk factors for type 2 diabetes, but the extent to which these factors are associated is unknown.
Methods: We examined the association between parental history of diabetes and a type 2 diabetes genetic risk score (GRS) in two cohort studies from Finland (population-based PPP-Botnia study) and the US (family-based Framingham Offspring Study).
Results: Mean (95% CI) GRS increased from 16.8 (16.8-16.9) to 16.9 (16.8-17.1) to 17.1 (16.8-17.4) among PPP-Botnia participants with 0, 1, and 2 parents with diabetes, respectively (p(trend)=0.03). The trend was similar among Framingham Offspring but was not statistically significant (p=0.07). The meta-analyzed p value for trend from the two studies was 0.005.
Conclusions: The very modest associations reported above suggest that the increased risk of diabetes in offspring of parents with diabetes is largely the result of shared environmental/lifestyle factors and/or hitherto unknown genetic factors.
Conflict of interest statement
Conflict of Interest
The authors have a competing interest to declare. J.B.M. has a consulting agreement with Interleukin Genetics, Inc. No other potential conflicts of interest relevant to this article were reported.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Source: PubMed