Comparison of artemis 2 ultrasound and Visante optical coherence tomography corneal thickness profiles

Roxana Ursea, Matthew Feng, Raksha Urs, Arindam RoyChoudhury, Ronald H Silverman, Roxana Ursea, Matthew Feng, Raksha Urs, Arindam RoyChoudhury, Ronald H Silverman

Abstract

Purpose: To compare corneal thickness profiles of cross-sections of cornea determined by arc-scanned immersion ultrasound and optical coherence tomography (OCT).

Methods: Corneas of 28 eyes from 14 participants were scanned in triplicate using the Artemis 2 high-frequency arc-scanned ultrasound system (ArcScan Inc) and the Visante OCT system (Carl Zeiss Meditec). Corneal thickness and reproducibility were compared within 3.5 mm of central cornea in the horizontal plane.

Results: Although highly correlated, Visante central and peripheral corneal thickness values were systematically thinner than Artemis 2 values. Within the central 0.5 mm, the difference was approximately 8 μm, but the difference increased with distance from the center. Reproducibility for each instrument was comparable, measuring <4 μm centrally and increasing peripherally.

Conclusions: Visante OCT measurements of corneal thickness are thinner than Artemis 2 ultrasound values centrally with an increasing difference with peripheral position. Measurement reproducibility was comparable for the two techniques.

Copyright 2013, SLACK Incorporated.

Figures

Figure 1
Figure 1
Comparative plots of mean corneal thickness±standard error as a function of horizontal position in Artemis and Visante for all eyes.
Figure 2
Figure 2
Bland-Altman plots comparing Artemis and Visante determinations of corneal thickness centrally (top), 2.5-mm nasally (middle), and 2.5-mm temporally (bottom) for left (OS) and right (OD) eyes. The solid line represents the mean difference (Visante-Artemis) and dashed lines represent the 95% confidence bounds.
Figure 3
Figure 3
Comparative plots of reproducibility for repeated measurements of corneal thickness as a function of position for Artemis 2 and Visante.
Figure 4
Figure 4
Plot of mean difference±standard deviation between comparable positions on the left and right eyes for Artemis 2 and Visante.

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