Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons

Brad Petrisor, Kyle Jeray, Emil Schemitsch, Beate Hanson, Sheila Sprague, David Sanders, Mohit Bhandari, FLOW Investigators, Brad Petrisor, Kyle Jeray, Emil Schemitsch, Beate Hanson, Sheila Sprague, David Sanders, Mohit Bhandari, FLOW Investigators

Abstract

Background: Although surgeons acknowledge the importance of irrigating open fracture wounds, the choice of irrigating fluid and delivery pressure remains controversial. Our objective was to clarify current opinion with regard to the irrigation of open fracture wounds.

Methods: We used a cross-sectional survey and a sample-to-redundancy strategy to examine surgeons' preferences in the initial management of open fracture wounds. We mailed this survey to members of the Canadian Orthopaedic Association and delivered it to attendees of an international fracture course (AO, Davos, Switzerland).

Results: Of the 1,764 surgeons who received the questionnaire, 984 (55.8%) responded. In the management of open wounds, the majority of surgeons surveyed, 676 (70.5%), favoured normal saline alone. Bacitracin solution was used routinely by only 161 surgeons (16.8%). The majority of surgeons, 695 (71%) used low pressures when delivering the irrigating solution to the wound. There was, however considerable variation in what pressures constituted high versus low pressure lavage. The overwhelming majority of surgeons, 889 (94.2%), reported they would change their practice if a large randomized controlled trial showed a clear benefit of an irrigating solution - especially if it was different from the solution they used.

Conclusion: The majority of surgeons favour both normal saline and low pressure lavage for the initial management of open fracture wounds. However, opinions varied as regards the comparative efficacy of different solutions, the use of additives and high versus low pressure. Surgeons have expressed considerable support for a trial evaluating both irrigating solutions and pressures.

References

    1. Court-Brown Charles, McQueen Margaret, Tornetta Paul., III . Trauma. 1. Philadelphia, Lippincott Williams and Wilkins; 2006.
    1. Anglen JO. Wound irrigation in musculoskeletal injury. J Am Acad Orthop Surg. 2001;9:219–226.
    1. Anglen JO, Gainor BJ, Simpson WA, Christensen G. The use of detergent irrigation for musculoskeletal wounds. Int Orthop. 2003;27:40–46.
    1. Bhandari M, Guyatt GH, Swiontkowski MF, Schemitsch EH. Treatment of open fractures of the shaft of the tibia. J Bone Joint Surg Br. 2001;83:62–68. doi: 10.1302/0301-620X.83B1.10986.
    1. Bhandari M, Tornetta P, III, Sprague S, Najibi S, Petrisor B, Griffith L, Guyatt GH. Predictors of reoperation following operative management of fractures of the tibial shaft. J Orthop Trauma. 2003;17:353–361. doi: 10.1097/00005131-200305000-00006.
    1. Petrisor B, Anderson S, Court-Brown CM. Infection after reamed intramedullary nailing of the tibia: a case series review. J Orthop Trauma. 2005;19:437–441. doi: 10.1097/01.bot.0000161542.93624.8d.
    1. Valenziano CP, Chattar-Cora D, O'Neill A, Hubli EH, Cudjoe EA. Efficacy of primary wound cultures in long bone open extremity fractures: are they of any value? Arch Orthop Trauma Surg. 2002;122:259–261. doi: 10.1007/s00402-001-0363-6.
    1. Khatod M, Botte MJ, Hoyt DB, Meyer RS, Smith JM, Akeson WH. Outcomes in open tibia fractures: relationship between delay in treatment and infection. J Trauma. 2003;55:949–954.
    1. Spencer J, Smith A, Woods D. The effect of time delay on infection in open long-bone fractures: a 5-year prospective audit from a district general hospital. Annals of the Royal College of Surgeons of England. 2004;86:108–112. doi: 10.1308/003588404322827491.
    1. Tsukayam DT, Schmidt AH. Open fractures. Current Treatment Options in Infectious Disease. 2001;3:301–307.
    1. Anglen JO. Comparison of soap and antibiotic solutions for irrigation of lower-limb open fracture wounds. A prospective, randomized study. J Bone Joint Surg Am. 2005;87:1415–1422. doi: 10.2106/JBJS.D.02615.
    1. Bhandari M, Adili A, Schemitsch EH. The efficacy of low-pressure lavage with different irrigating solutions to remove adherent bacteria from bone. J Bone Joint Surg Am. 2001;83-A:412–419.
    1. Bhandari M, Thompson K, Adili A, Shaughnessy SG. High and low pressure irrigation in contaminated wounds with exposed bone. Int J Surg Investig. 2000;2:179–182.
    1. Caprise PA, Jr, Miclau T, Dahners LE, Dirschl DR. High-pressure pulsatile lavage irrigation of contaminated fractures: effects on fracture healing. J Orthop Res. 2002;20:1205–1209. doi: 10.1016/S0736-0266(02)00049-9.
    1. Griffith L, Cook DJ, Guyatt GH, Charles CA. Comparison of open and closed questionnaire formats in obtaining demographic information from Canadian general internists. Journal of Clinical Epidemiology. 1999:997–1005. doi: 10.1016/S0895-4356(99)00106-7.
    1. Armstrong D, Ashworth M. When questionnaire response rates do matter: a survey of general practitioners and their views of NHS changes. British Journal of General Practice. 2000:479–480.
    1. Templeton L, Deehan A, Taylor C, Drummond C, Strang J. Surveying general practitioners: does a low response rate matter? British Journal of General Practice. 1997;47:91–94.
    1. Skedros , et al. Knowledge and opinions of orthopaedic surgeons concerning medical evaluation and treatment of patients with osteoporotic fracture. J Bone and Joint Surgery (American) 2006;88:18–24. doi: 10.2106/JBJS.D.02949.
    1. Skedros Hunt KJ, JG , Pitts TC. Variations in corticosteroid/anesthetic injections for painful shoulder conditions: comparisons among orthopaedic surgeons, rheumatologists, and physical medicine and primary-care physicians. BMC Musculoskelet Disorders. 2007;6:63. doi: 10.1186/1471-2474-8-63.
    1. Bhandari M, Schemitsch EH, Adili A, Lachowski RJ, Shaughnessy SG. High and low pressure pulsatile lavage of contaminated tibial fractures: an in vitro study of bacterial adherence and bone damage. J Orthop Trauma. 1999;13:526–533. doi: 10.1097/00005131-199911000-00002.
    1. Lee EW, Dirschl DR, Duff G, Dahners LE, Miclau T. High-pressure pulsatile lavage irrigation of fresh intraarticular fractures: effectiveness at removing particulate matter from bone. J Orthop Trauma. 2002;16:162–165. doi: 10.1097/00005131-200203000-00004.
    1. Polzin B, Ellis T, Dirschl DR. Effects of varying pulsatile lavage pressure on cancellous bone structure and fracture healing. J Orthop Trauma. 2006;20:261–266. doi: 10.1097/00005131-200604000-00005.
    1. Bhandari M, Adili A, Lachowski RJ. High pressure pulsatile lavage of contaminated human tibiae: an in vitro study. J Orthop Trauma. 1998;12:479–484. doi: 10.1097/00005131-199809000-00009.
    1. Bhandari M, Schemitsch EH. High-pressure irrigation increases adipocyte-like cells at the expense of osteoblasts in vitro. J Bone Joint Surg Br. 2002;84:1054–1061. doi: 10.1302/0301-620X.84B7.12532.
    1. Adili A, Bhandari M, Schemitsch EH. The biomechanical effect of high-pressure irrigation on diaphyseal fracture healing in vivo. J Orthop Trauma. 2002;16:413–417. doi: 10.1097/00005131-200207000-00008.
    1. Dirschl DR, Duff GP, Dahners LE, Edin M, Rahn BA, Miclau T. High pressure pulsatile lavage irrigation of intraarticular fractures: effects on fracture healing. J Orthop Trauma. 1998;12:460–463. doi: 10.1097/00005131-199809000-00005.
    1. Conroy BP, Anglen JO, Simpson WA, Christensen G, Phaup G, Yeager R, Gainor BJ. Comparison of castile soap, benzalkonium chloride, and bacitracin as irrigation solutions for complex contaminated orthopaedic wounds. J Orthop Trauma. 1999;13:332–337. doi: 10.1097/00005131-199906000-00002.
    1. Gainor BJ, Hockman DE, Anglen JO, Christensen G, Simpson WA. Benzalkonium chloride: a potential disinfecting irrigation solution. J Orthop Trauma. 1997;11:121–125. doi: 10.1097/00005131-199702000-00010.
    1. Moussa FW, Gainor BJ, Anglen JO, Christensen G, Simpson WA. Disinfecting agents for removing adherent bacteria from orthopaedic hardware. Clin Orthop Relat Res. 1996:255–262. doi: 10.1097/00003086-199608000-00032.
    1. Tarbox BB, Conroy BP, Malicky ES, Moussa FW, Hockman DE, Anglen JO, Simpson WA, Adelstein EH, Christensen G, Gainor BJ. Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds. Clin Orthop Relat Res. 1998:255–261.
    1. Anglen J, Apostoles PS, Christensen G, Gainor B, Lane J. Removal of surface bacteria by irrigation. J Orthop Res. 1996;14:251–254. doi: 10.1002/jor.1100140213.
    1. Marberry KM, Kazmier P, Simpson WA, Christensen GD, Phaup JG, Hendricks KJ, Anglen JO, Gainor BJ. Surfactant wound irrigation for the treatment of staphylococcal clinical isolates. Clin Orthop Relat Res. 2002:73–79. doi: 10.1097/00003086-200210000-00012.
    1. Museru LM, Kumar A, Ickler P. Comparison of isotonic saline, distilled water and boiled water in irrigation of open fractures. International Orthopaedics (SICOT) 1989;13:179–180. doi: 10.1007/BF00268044.

Source: PubMed

3
Tilaa