EUS-guided Radiofrequency Ablation (EUS-RFA) of Solid Pancreatic Neoplasm Using an 18-gauge Needle Electrode: Feasibility, Safety, and Technical Success
Stefano Francesco Crinò, Mirko D'Onofrio, Laura Bernardoni, Luca Frulloni, Michele Iannelli, Giuseppe Malleo, Salvatore Paiella, Alberto Larghi, Armando Gabbrielli, Stefano Francesco Crinò, Mirko D'Onofrio, Laura Bernardoni, Luca Frulloni, Michele Iannelli, Giuseppe Malleo, Salvatore Paiella, Alberto Larghi, Armando Gabbrielli
Abstract
Background and aims: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a promising technique for the treatment of pancreatic neoplasm. We evaluated the feasibility, safety, and technical success of pancreatic EUS-RFA performed in a single center.
Methods: 9 consecutive patients (8 with pancreatic adenocarcinoma and 1 with renal cancer metastasis) were referred for EUS-RFA between November 2016 and July 2017. EUS-RFA was performed using 18-gauge internally cooled electrode with a 5 or 10 mm exposed tip. Feasibility, technical success or early and late adverse events were assessed.
Results: One patient was excluded because of a large necrotic portion. EUS-RFA was feasible in all the other 8 (100%) cases. An ablated area inside the tumor was achieved in all treated patients. No early or late major adverse event was observed after a mean follow-up of 6 months. Three patients experienced mild post-procedural abdominal pain.
Conclusions: EUS-RFA seems a feasible, safe, and effective procedure for pancreatic neoplasms. Its role in the treatment and management of pancreatic masses must be further investigated.
Source: PubMed