BRAF-Directed Therapy in Metastatic Colorectal Cancer
Krittiya Korphaisarn, Scott Kopetz, Krittiya Korphaisarn, Scott Kopetz
Abstract
Activating BRAF (V-raf murine sarcoma viral oncogene homolog B) mutations occur in approximately 5% to 10% of patients with metastatic colorectal cancer, mostly V600E mutation, and it is associated with distinct clinical and pathological features. To date, there are no approved treatments to target this mutation. BRAF inhibitor monotherapy has limited efficacy, in contrast to metastatic melanoma. Combination strategies that block not only BRAF mutated kinase but other alternative pathways are ongoing and have demonstrated improved activity. This review aims to provide data about new strategies to target to BRAF gene mutation in metastatic colorectal cancer.
Conflict of interest statement
Conflict of interest: The authors have declared that no conflict of interest exists
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Source: PubMed