Evaluation of an mHealth tool to improve nutritional assessment among infants under 6 months in paediatric development clinics in rural Rwanda: Quasi-experimental study

Mathieu Nemerimana, Angelique Charlie Karambizi, Sabine Umutoniwase, Dale A Barnhart, Kathryn Beck, Vianney Kabundi Bihibindi, Kim Wilson, Alphonse Nshimyiryo, Jessica Bradford, Silas Havugarurema, Alphonsine Uwamahoro, Emmanuel Nsabyamahoro, Catherine M Kirk, Mathieu Nemerimana, Angelique Charlie Karambizi, Sabine Umutoniwase, Dale A Barnhart, Kathryn Beck, Vianney Kabundi Bihibindi, Kim Wilson, Alphonse Nshimyiryo, Jessica Bradford, Silas Havugarurema, Alphonsine Uwamahoro, Emmanuel Nsabyamahoro, Catherine M Kirk

Abstract

Infants born preterm, low birthweight or with other perinatal complications require frequent and accurate growth monitoring for optimal nutrition and growth. We implemented an mHealth tool to improve growth monitoring and nutritional status assessment of high risk infants. We conducted a pre-post quasi-experimental study with a concurrent control group among infants enrolled in paediatric development clinics in two rural Rwandan districts. During the pre-intervention period (August 2017-January 2018), all clinics used standard paper-based World Health Organization (WHO) growth charts. During the intervention period (August 2018-January 2019), Kirehe district adopted an mHealth tool for child growth monitoring and nutritional status assessment. Data on length/height; weight; length/height-for-age (L/HFA), weight-for-length/height (WFL/H) and weight-for-age (WFA) z-scores; and interval growth were tracked at each visit. We conducted a 'difference-in-difference' analysis to assess whether the mHealth tool was associated with greater improvements in completion and accuracy of nutritional assessments and nutritional status at 2 and 6 months of age. We observed 3529 visits. mHealth intervention clinics showed significantly greater improvements on completeness for corrected age (endline: 65% vs. 55%; p = 0.036), L/HFA (endline: 82% vs. 57%; p ≤ 0.001), WFA (endline: 93% vs. 67%; p ≤ 0.001) and WFL/H (endline: 90% vs. 59%; p ≤ 0.001) z-scores compared with control sites. Accuracy of growth monitoring did not improve. Prevalence of stunting, underweight and inadequate interval growth at 6-months corrected age decreased significantly more in the intervention clinics than in control clinics. Results suggest that integrating mHealth nutrition interventions is feasible and can improve child nutrition outcomes. Improved tool design may better promote accuracy.

Trial registration: ClinicalTrials.gov NCT03665012.

Keywords: child development; growth monitoring; high-risk infants; mHealth; nutrition; small and sick newborns.

Conflict of interest statement

The authors declare that they have no conflicts of interest.

© 2021 The Authors. Maternal & Child Nutrition published by John Wiley & Sons Ltd.

References

    1. Barnett, I., Sulistyo, S., Befani, B., KariSari, K., Sharmin, S., & Dewi, D. (2016). Mixed‐method impact evaluation of a mobile phone application for nutrition monitoring in Indonesia (No. IDS Evidence Report; 200). Sussex, UK: Institute of Development Studies.
    1. Beck, K., Kirk, C. M., Bradford, J., Mutaganzwa, C., Nahimana, E., & Bigirumwami, O. (2018). The pediatric development clinic: A model to improve outcomes for high‐risk children aged under‐five in rural Rwanda. Emergency Nutrition Network Field Exchange, 58, 51–53.
    1. Bonilla, C., Brauer, P., Royall, D., Keller, H., Hanning, R. M., & DiCenso, A. (2015). Use of electronic dietary assessment tools in primary care: An interdisciplinary perspective. BMC Medical Informatics and Decision Making, 15, 14. 10.1186/s12911-015-0138-6
    1. Bradford, J., Beck, K., Nshimyiryo, A., Wilson, K., Mutaganzwa, C., Havugarurema, S., Ngamije, P., Alphonsine, U., Kirk, C. M. (2020). Nutritional evaluation and growth of infants in a Rwandan neonatal follow‐up clinic. Maternal and Child Nutrition, 16(4), e13026. 10.1111/mcn.13026
    1. Chanani, S., Wacksman, J., Deshmukh, D., Pantvaidya, S., Fernandez, A., & Jayaraman, A. (2016). M‐Health for improving screening accuracy of acute malnutrition in a community‐based management of acute malnutrition program in Mumbai Informal Settlements. Food and Nutrition Bulletin, 37(4), 504–516. 10.1177/0379572116657241
    1. Cheung, Y. B. (2007). A modified least‐squares regression approach to the estimation of risk difference. American Journal of Epidemiology, 166(11), 1337–1344. 10.1093/aje/kwm223
    1. Dainty, G. J., Reith, D. M., & Taylor, B. J. (2019). Introduction and uptake of electronic growth charts in southern New Zealand. Journal of Paediatrics and Child Health, 55(4), 421–427.
    1. Danaei, G., Andrews, K. G., Sudfeld, C. R., Fink, G., McCoy, D. C., Peet, E., Sania, A., Smith Fawzi, M. C., Ezzati, M., & Fawzi, W. W. (2016). Risk factors for childhood stunting in 137 developing countries: A comparative risk assessment analysis at global, regional, and country levels. PLoS Medicine, 13(11), e1002164. 10.1371/journal.pmed.1002164
    1. Darmstadt, G. L., Shiffman, J., & Lawn, J. E. (2015). Advancing the newborn and stillbirth global agenda: Priorities for the next decade. Archives of Disease in Childhood, 100(Suppl1), S13–S18. 10.1136/archdischild-2013-305557
    1. Dimick, J. B., & Ryan, A. M. (2014). Methods for evaluating changes in health care policy: The difference‐in‐differences approach. Journal of the American Medical Association, 312(22), 2401–2402. 10.1001/jama.2014.16153
    1. Ezeofor, I. O., Garcia, A. L., Ibeziako, S. N., Mutoro, A. N., & Wright, C. M. (2017). Health staff understanding, application, and interpretation of growth charts in Nigeria. Maternal & Child Nutrition, 13, e12402.
    1. Källander, K., Tibenderana, J. K., Akpogheneta, O. J., Strachan, D. L., Hill, Z., ten Asbroek, A. H., Conteh, L., Kirkwood, B. R., & Meek, S. R. (2013). Mobile health (mHealth) approaches and lessons for increased performance and retention of community health workers in low‐and middle‐income countries: A review. Journal of Medical Internet Research, 15(1), e17. 10.2196/jmir.2130
    1. Kerac, M., Postels, D. G., Mallewa, M., Jalloh, A. A., Voskuijl, W. P., Groce, N., Gladstone, M., & Molyneux, E. (2014). The interaction of malnutrition and neurologic disability in Africa. Seminars in Pediatric Neurology, 21, 42–49. 10.1016/j.spen.2014.01.003
    1. Lawn, J. E., Blencowe, H., Oza, S., You, D., Lee, A. C., Waiswa, P., Lalli, M., Bhutta, Z., Barros, A. J., Christian, P., Mathers, C., & Lancet Every Newborn Study Group . (2014). Every newborn: Progress, priorities, and potential beyond survival. The Lancet, 384(9938), 189–205. 10.1016/S0140-6736(14)60496-7
    1. Mansournia, M. A., Nazemipour, M., Naimi, A. I., Collins, G. S., & Campbell, M. J. (2020). Reflections on modern methods: Demystifying robust standard errors for epidemiologists. International Journal of Epidemiology, dyaa260. 10.1093/ije/dyaa260
    1. Manzi, A., Magge, H., Hedt‐Gauthier, B. L., Michaelis, A. P., Cyamatare, F. R., Nyirazinyoye, L., Hirschhorn, L. R., & Ntaganira, J. (2014). Clinical mentorship to improve pediatric quality of care at the health centers in rural Rwanda: A qualitative study of perceptions and acceptability of health care workers. BMC Health Services Research, 14(275). 10.1186/1472-6963-14-275
    1. Mechael, P., Batavia, H., Kaonga, N., Searle, S., Kwan, A., Goldberger, A., & Ossman, J. (2010). Barriers and gaps affecting mHealth in low and middle income countries: Policy white paper (pp. 1–79). Columbia University Earth Institute, Center for Global Health and Economic development (CGHED) with mHealth Alliance.
    1. Mutoro, A. N., & Wright, C. M. (2013). Diagnosing childhood undernutrition and accuracy of plotting growth charts in Kenya. Journal of Tropical Pediatrics, 59(5), 419–422. 10.1093/tropej/fmt045
    1. National Institute of Statistics of Rwanda (NISR) [Rwanda] , Ministry of Finance and Economic Planning (MINECOFIN) [Rwanda] . (2012). Rwanda fourth population and housing census. Thematic Report: Population Size, Structure and Distribution. Kigali, Rwanda. Retrieved from
    1. Ngabireyimana, E., Mutaganzwa, C., Kirk, C. M., Miller, A. C., Wilson, K., Dushimimana, E., Bigirumwami, O., Mukakabano, E. S., Nkikabahizi, F., & Magge, H. (2017). A retrospective review of the pediatric development clinic implementation: A model to improve medical, nutritional and developmental outcomes of at‐risk under‐five children in rural Rwanda. Maternal Health, Neonatology and Perinatology, 3(1), 13.
    1. Pop‐Eleches, C., Thirumurthy, H., Habyarimana, J. P., Zivin, J. G., Goldstein, M. P., de Walque, D., MacKeen, L., Haberer, J., Kimaiyo, S., Sidle, J., Ngare, D., & Bangsberg, D. R. (2011). Mobile phone technologies improve adherence to antiretroviral treatment in a resource‐limited setting: A randomized controlled trial of text message reminders. Aids, 25(6), 825–834. 10.1097/QAD.0b013e32834380c1
    1. Rogers, W. (1993). Regression standard errors in clustered samples. Stata Technical Bulletin, 13, 19–23.
    1. Valérie, M., Member of the Collaborative Statement Advisory Group , & Nutrition and Gastroenterology Committee . (2010). Promoting optimal monitoring of child growth in Canada: Using the new World Health Organization growth charts. Paediatrics & Child Health, 15(2), 77–79.
    1. Villar, J., Giuliani, F., Barros, F., Roggero, P., Zarco, I. A. C., Rego, M. A. S., Ochieng, R., Gianni, M. L., Rao, S., Lambert, A., Ryumina, I., & Kennedy, S. (2018). Monitoring the postnatal growth of preterm infants: A paradigm change. Pediatrics, 141(2), e20172467. 10.1542/peds.2017-2467
    1. Villar, J., Ismail, L. C., Victora, C. G., Ohuma, E. O., Bertino, E., Altman, D. G., Lambert, A., Papageorghiou, A. T., Carvalho, M., Jaffer, Y. A., Gravett, M. G., Purwar, M., Frederick, I. O., Noble, A. J., Pang, R., Barros, F. C., Chumlea, C., Bhutta, Z. A., & Kennedy, S. H. (2014). International standards for newborn weight, length, and head circumference by gestational age and sex: The newborn cross‐sectional study of the INTERGROWTH‐21st project. The Lancet, 384(9946), 857–868. 10.1016/S0140-6736(14)60932-6
    1. World Health Organization . (2006). WHO child growth standards: Length/height‐for‐age, weight‐for‐age, weight‐for‐length, weight‐for‐height and body mass index‐for‐age: Methods and development.
    1. Zapata, B. C., Fernández‐Alemán, J. L., Idri, A., & Toval, A. (2015). Empirical studies on usability of mHealth apps: A systematic literature review. Journal of Medical Systems, 39(2), 1. 10.1007/s10916-014-0182-2

Source: PubMed

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