Mortality in severe meningococcal disease

K Thorburn, P Baines, A Thomson, C A Hart, K Thorburn, P Baines, A Thomson, C A Hart

Abstract

Aim: To evaluate mortality of critically ill children admitted with meningococcal disease.

Methods: Prospective study of all children admitted to a regional paediatric intensive care unit (PICU) between January 1995 and March 1998 with meningococcal disease. Outcome measures were actual overall mortality, predicted mortality (by PRISM), and standardised mortality ratio.

Results: A total of 123 children were admitted with meningococcal disease. There was an overall PICU mortality of 11 children (8.9%). The total mortality predicted by PRISM was 24.9. The standardised mortality ratio (SMR) was 0.44. Results were compared with those from four previously published meningococcal PICU studies (USA, Australia, UK, Netherlands) in which PRISM scores were calculated. The overall PICU mortality and SMR were lower than those in the previously published studies.

Conclusion: Compared with older studies and calibrating for disease severity, this study found a decrease in the mortality of critically ill children with meningococcal disease.

References

    1. Crit Care Med. 1993 May;21(5):706-11
    1. BMJ. 1997 Sep 27;315(7111):774-9
    1. Eur J Pediatr. 2000 Apr;159(4):232-6
    1. Eur J Pediatr. 2000 Apr;159(4):277-82
    1. Clin Infect Dis. 1999 Apr;28(4):770-7
    1. Lancet. 2000 Sep 16;356(9234):961-7
    1. J Pediatr. 1966 Mar;68(3):457-67
    1. Radiology. 1982 Apr;143(1):29-36
    1. Lancet. 1987 Jul 4;2(8549):38
    1. Crit Care Med. 1988 Nov;16(11):1110-6
    1. Pediatr Infect Dis J. 1989 Jan;8(1):8-11
    1. N Engl J Med. 1992 Apr 23;326(17):1161-2
    1. Crit Care Med. 1993 Mar;21(3):447-52
    1. Intensive Care Med. 2000 Jan;26(1):6-7
    1. Crit Care Med. 1994 Sep;22(9):1385-91
    1. Crit Care Med. 1994 Sep;22(9):1477-84
    1. Crit Care Med. 1995 Feb;23(2):221-2
    1. Crit Care Med. 1995 Feb;23(2):238-45
    1. Scand J Infect Dis. 1971;3(1):17-25
    1. Intensive Care Med. 1996 Mar;22(3):259-63
    1. Crit Care Med. 1996 May;24(5):743-52
    1. J Infect Dis. 1996 Oct;174(4):878-80
    1. Scand J Infect Dis. 1996;28(1):47-51
    1. Intensive Care Med. 1996 Dec;22(12):1433-41
    1. Intensive Care Med. 1997 Feb;23(2):201-7

Source: PubMed

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