Efficacy of Chinese eye exercises on reducing accommodative lag in school-aged children: a randomized controlled trial

Shi-Ming Li, Meng-Tian Kang, Xiao-Xia Peng, Si-Yuan Li, Yang Wang, Lei Li, Jing Yu, Li-Xin Qiu, Yun-Yun Sun, Luo-Ru Liu, He Li, Xin Sun, Michel Millodot, Ningli Wang, Shi-Ming Li, Meng-Tian Kang, Xiao-Xia Peng, Si-Yuan Li, Yang Wang, Lei Li, Jing Yu, Li-Xin Qiu, Yun-Yun Sun, Luo-Ru Liu, He Li, Xin Sun, Michel Millodot, Ningli Wang

Abstract

Purpose: To evaluate the efficacy of Chinese eye exercises on reducing accommodative lag in children by a randomized, double-blinded controlled trial.

Methods: A total of 190 children aged 10 to 14 years with emmetropia to moderate myopia were included. They were randomly allocated to three groups: standard Chinese eye exercises group (trained for eye exercises by doctors of traditional Chinese medicine); sham point eye exercises group (instructed to massage on non-acupoints); and eyes closed group (asked to close their eyes without massage). Primary outcome was change in accommodative lag immediately after intervention. Secondary outcomes included changes in corrected near and distant visual acuity, and visual discomfort score.

Results: Children in the standard Chinese eye exercises group had significantly greater alleviation of accommodative lag (-0.10 D) than those in sham point eye exercises group (-0.03 D) and eyes closed group (0.07 D) (P = 0.04). The proportion of children with alleviation of accommodative lag was significantly higher in the standard Chinese eye exercises group (54.0%) than in the sham point eye exercises group (32.8%) and the eyes closed group (34.9%) (P = 0.03). No significant differences were found in secondary outcomes.

Conclusion: Chinese eye exercises as performed daily in primary and middle schools in China have statistically but probably clinically insignificant effect in reducing accommodative lag of school-aged children in the short-term. Considering the higher amounts of near work load of Chinese children, the efficacy of eye exercises may be insufficient in preventing myopia progression in the long-term.

Trial registration: ClinicalTrials.gov NCT01756287.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. Locations of acupoints of standard…
Fig 1. Locations of acupoints of standard Chinese eye exercises and sham point eye exercises.
Fig 2. Flow of participant through trial.
Fig 2. Flow of participant through trial.
Fig 3. Distribution and mean of accommodative…
Fig 3. Distribution and mean of accommodative lag before and after intervention.

References

    1. Pan CW, Ramamurthy D, Saw SM (2012) Worldwide prevalence and risk factors for myopia. Ophthalmic Physiol Opt 32: 3–16. 10.1111/j.1475-1313.2011.00884.x
    1. Morgan IG, Ohno-Matsui K, Saw SM (2012) Myopia. Lancet 379: 1739–1748. 10.1016/S0140-6736(12)60272-4
    1. Liang YB, Friedman DS, Wong TY, Zhan SY, Sun LP, et al. (2008) Prevalence and causes of low vision and blindness in a rural chinese adult population: the Handan Eye Study. Ophthalmology 115: 1965–1972. 10.1016/j.ophtha.2008.05.030
    1. Hsu WM, Cheng CY, Liu JH, Tsai SY, Chou P (2004) Prevalence and causes of visual impairment in an elderly Chinese population in Taiwan: the Shihpai Eye Study. Ophthalmology 111: 62–69.
    1. Buch H, Vinding T, La Cour M, Appleyard M, Jensen GB, et al. (2004) Prevalence and causes of visual impairment and blindness among 9980 Scandinavian adults: the Copenhagen City Eye Study. Ophthalmology 111: 53–61.
    1. Ostberg O, Horie Y, Feng Y (1992) On the merits of ancient Chinese eye acupressure practices. Appl Ergon 23: 343–348.
    1. Zhao J, Pan X, Sui R, Munoz SR, Sperduto RD, et al. (2000) Refractive Error Study in Children: results from Shunyi District, China. Am J Ophthalmol 129: 427–435.
    1. He M, Zheng Y, Xiang F (2009) Prevalence of myopia in urban and rural children in mainland China. Optom Vis Sci 86: 40–44. 10.1097/OPX.0b013e3181940719
    1. Wei ML, Liu JP, Li N, Liu M (2011) Acupuncture for slowing the progression of myopia in children and adolescents. Cochrane Database Syst Rev 9: CD007842 10.1002/14651858.CD007842.pub2
    1. Xie HL, Xie ZK, Zhou F, Hu L (2013) [Myopia prevalence and influencing factor analysis of primary and middle school students in our country]. Zhonghua Yi Xue Za Zhi 93: 999–1002.
    1. Zhao R, He X-G, Zhu J-f (2012) Beliefs and behavior related to Chinese students eye exercises among primary and secondary school teachers and students in Shanghai Chin J Sch Health 33: 270–272.
    1. Xiong R, Liu Q (2001) Survey on the nonstandard performance of Chinese eye exercises in children. Chin J School Health 22: 566.
    1. Lin Z, Vasudevan B, Jhanji V, Gao TY, Wang NL, et al. (2013) Eye exercises of acupoints: their impact on refractive error and visual symptoms in Chinese urban children. BMC Complement Altern Med 13: 306 10.1186/1472-6882-13-306
    1. Shih YF, Lin LL, Hwang CY, Huang JK, Hung PT, et al. (1995) The effects of Qi-Qong ocular exercise on accommodation. Chin J Physiol 38: 35–42.
    1. McBrien NA, Millodot M (1986) The effect of refractive error on the accommodative response gradient. Ophthalmic Physiol Opt 6: 145–149.
    1. Gwiazda J, Thorn F, Bauer J, Held R (1993) Myopic children show insufficient accommodative response to blur. Invest Ophthalmol Vis Sci 34: 690–694.
    1. Allen PM, O’Leary DJ (2006) Accommodation functions: co-dependency and relationship to refractive error. Vision Res 46: 491–505.
    1. Rosenfield M, Desai R, Portello JK (2002) Do progressing myopes show reduced accommodative responses? Optom Vis Sci 79: 268–273.
    1. Seidel D, Gray LS, Heron G (2005) The effect of monocular and binocular viewing on the accommodation response to real targets in emmetropia and myopia. Optom Vis Sci 82: 279–285.
    1. Subbaram MV, Bullimore MA (2002) Visual acuity and the accuracy of the accommodative response. Ophthalmic Physiol Opt 22: 312–318.
    1. Goss DA (1991) Clinical accommodation and heterophoria findings preceding juvenile onset of myopia. Optom Vis Sci 68: 110–116.
    1. Gwiazda J, Thorn F, Held R (2005) Accommodation, accommodative convergence, and response AC/A ratios before and at the onset of myopia in children. Optom Vis Sci 82: 273–278.
    1. Price H, Allen PM, Radhakrishnan H, Calver R, Rae S, et al. (2013) The Cambridge Anti-myopia Study: variables associated with myopia progression. Optom Vis Sci 90: 1274–1283. 10.1097/OPX.0000000000000067
    1. Mutti DO, Mitchell GL, Hayes JR, Jones LA, Moeschberger ML, et al. (2006) Accommodative lag before and after the onset of myopia. Invest Ophthalmol Vis Sci 47: 837–846.
    1. Li SM, Liu LR, Li SY, Ji YZ, Fu J, et al. (2013) Design, methodology and baseline data of a school-based cohort study in central China: the Anyang Childhood Eye Study. Ophthalmic Epidemiol 20: 348–359. 10.3109/09286586.2013.842596
    1. Li SM, Li SY, Liu LR, Guo JY, Chen W, et al. (2013) Full correction and Undercorrection of Myopia Evaluation Trial: design and baseline data of a randomized, controlled, double-blind trial. Clin Experiment Ophthalmol 41: 329–338. 10.1111/j.1442-9071.2012.02884.x
    1. Kirkwood BR, Sterne JAC (2003) Essential Medical Statistics.Oxford: Blackwell Science.
    1. WHO Reginoal Officer for the Western Pacific (2008) WHO Standard Acupuncture Point Locations in the Western Pacific Region. Manila: World Health Organization;
    1. So DW (2002) Acupuncture outcomes, expectations, patient-provider relationship, and the placebo effect: implications for health promotion. Am J Public Health 92: 1662–1667.
    1. Nakatsuka C, Hasebe S, Nonaka F, Ohtsuki H (2005) Accommodative lag under habitual seeing conditions: Comparison between myopic and emmetropic children. Japanese Journal of Ophthalmology 49: 189–194.
    1. Chase C, Tosha C, Borsting E, Ridder WH 3rd (2009) Visual discomfort and objective measures of static accommodation. Optom Vis Sci 86: 883–889. 10.1097/OPX.0b013e3181ae1b7c
    1. Li SM, Liu LR, Li SY, Ji YZ, Fu J, et al. (2013) Design, methodology and baseline data of a school-based cohort study in central China: the Anyang Childhood Eye Study. Ophthalmic Epidemiol 20: 348–359. 10.3109/09286586.2013.842596
    1. Zhu X, Winawer JA, Wallman J (2003) Potency of myopic defocus in spectacle lens compensation. Invest Ophthalmol Vis Sci 44: 2818–2827.
    1. Norton TT, Siegwart JT Jr, Amedo AO (2006) Effectiveness of hyperopic defocus, minimal defocus, or myopic defocus in competition with a myopiagenic stimulus in tree shrew eyes. Invest Ophthalmol Vis Sci 47: 4687–4699.
    1. Zhu X, Park TW, Winawer J, Wallman J (2005) In a matter of minutes, the eye can know which way to grow. Invest Ophthalmol Vis Sci 46: 2238–2241.
    1. Zhu X (2013) Temporal integration of visual signals in lens compensation (a review). Exp Eye Res 114: 69–76. 10.1016/j.exer.2013.02.014
    1. McBrien NA, Moghaddam HO, Reeder AP (1993) Atropine reduces experimental myopia and eye enlargement via a nonaccommodative mechanism. Invest Ophthalmol Vis Sci 34: 205–215.
    1. Berntsen DA, Sinnott LT, Mutti DO, Zadnik K (2012) A randomized trial using progressive addition lenses to evaluate theories of myopia progression in children with a high lag of accommodation. Invest Ophthalmol Vis Sci 53: 640–649. 10.1167/iovs.11-7769
    1. Berntsen DA, Sinnott LT, Mutti DO, Zadnik K, Group CS (2011) Accommodative lag and juvenile-onset myopia progression in children wearing refractive correction. Vision Res 51: 1039–1046. 10.1016/j.visres.2011.02.016
    1. Li SM, Ji YZ, Wu SS, Zhan SY, Wang B, et al. (2011) Multifocal versus single vision lenses intervention to slow progression of myopia in school-age children: a meta-analysis. Surv Ophthalmol 56: 451–460. 10.1016/j.survophthal.2011.06.002
    1. Sheppard AL, Davies LN (2010) Clinical evaluation of the Grand Seiko Auto Ref/Keratometer WAM-5500. Ophthalmic Physiol Opt 30: 143–151. 10.1111/j.1475-1313.2009.00701.x
    1. Liu H, Xu J, Shan B, Li Y, Li L, et al. (2012) Determining the precise cerebral response to acupuncture: an improved FMRI study. PLoS One 7: e49154 10.1371/journal.pone.0049154
    1. Naruse S, Mori K, Kurihara M (2000) Chorioretinal blood flow changes following acupuncture between thumb and forefinger [in Japanese]. Nippon Ganka Gakkai Zasshi 104: 717–723.
    1. An YS, Moon SK, Min IK, Kim DY (2009) Changes in regional cerebral blood flow and glucose metabolism following electroacupuncture at LI 4 and LI 11 in normal volunteers. J Altern Complement Med 15: 1075–1081. 10.1089/acm.2009.0257
    1. Li G, Cheung RT, Ma QY, Yang ES (2003) Visual cortical activations on fMRI upon stimulation of the vision-implicated acupoints. Neuroreport 14: 669–673.
    1. Lai X, Zhang G, Huang Y, Tang C, Yang J, et al. (2009) A cerebral functional imaging study by positron emission tomography in healthy volunteers receiving true or sham acupuncture needling. Neurosci Lett 452: 194–199. 10.1016/j.neulet.2009.01.052
    1. Kim TH, Kang JW, Kim KH, Kang KW, Shin MS, et al. (2012) Acupuncture for the treatment of dry eye: a multicenter randomised controlled trial with active comparison intervention (artificial teardrops). PLoS One 7: e36638 10.1371/journal.pone.0036638
    1. Park JM, Park SU, Jung WS, Moon SK (2011) Carthami-Semen acupuncture point injection for chronic daily headache: a pilot, randomised, double-blind, controlled trial. Complement Ther Med 19 Suppl 1: S19–25. 10.1016/j.ctim.2010.09.004
    1. Liang C-K, Ho T-Y, Li T-C, Hsu W-M, Li T-M, et al. (2008) A combined therapy using stimulating auricular acupoints enhances lower-level atropine eyedrops when used for myopia control in school-aged children evaluated by a pilot randomized controlled clinical trial. Complementary Therapies in Medicine 16: 305–310. 10.1016/j.ctim.2008.04.007
    1. Ip JM, Saw SM, Rose KA, Morgan IG, Kifley A, et al. (2008) Role of near work in myopia: findings in a sample of Australian school children. Invest Ophthalmol Vis Sci 49: 2903–2910. 10.1167/iovs.07-0804
    1. (2013) The 2013 International Myopia Conference in California. Ophthalmic and Physiological Optics 33: 661–674.

Source: PubMed

3
Tilaa