Comparative evaluation of locally delivered minocycline and metronidazole in the treatment of periodontitis

Nymphea Pandit, Ritu Dahiya, Rajan Gupta, Deepika Bali, Abhinav Kathuria, Nymphea Pandit, Ritu Dahiya, Rajan Gupta, Deepika Bali, Abhinav Kathuria

Abstract

Objective: The aim of this study was to evaluate and compare the efficacy of subgingivally delivered Minocycline microspheres and 25% Metronidazole gel when used as an adjunct to scaling and root planing (SRP) in the treatment of chronic periodontitis.

Materials and methods: A randomized, controlled, single center study was conducted involving 60 sites in 20 patients suffering from moderate to advanced chronic periodontitis. Each patient contributed three sites which were randomized to three treatment groups: SRP + insertion of Minocycline microspheres at day 1 (Group A), SRP + insertion of Metronidazole gel at day 1 and at day 7 (Group B), and SRP alone (Group C). Gingival index (GI), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at day 1, 1 month, and 3 months post therapy.

Results: All treatments showed significant reductions in PPD and CAL at 1 and 3 months when compared to baseline values (P < 0.001). At 3 months, sites treated with minocycline showed an additional reduction in PPD of 0.85 ± 0.03 mm, significantly greater than SRP alone. Differences in mean PPD reduction between Group B and Group C and between Group A and Group B were not significant. At 3 months, difference in CAL gain between Group A and C was 0.50 ± 0.45, which was statistically significant and between Group B and C was 0.35 ± 0.11, which was not found to be statistically significant (P = 0.20). Differences in relative CAL between Group A and Group B were also not found to be statistically significant (P = 0.53).

Conclusion: The results concluded that treatment with Minocycline microspheres and Metronidazole gel improve PPD and CAL in patients with periodontitis compared to SRP alone.

Keywords: Local drug delivery; metronidazole gel; minocycline microspheres.

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Insertion of minocycline microspheres
Figure 2
Figure 2
Insertion of metronidazole gel
Figure 3
Figure 3
Mean pocket depth reduction at different time intervals
Figure 4
Figure 4
Mean clinical attachment gain at different time intervals

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