Potential for personalised application of inhaled nitric oxide in COVID-19 pneumonia

Benjamin Garfield, Charles McFadyen, Charlotte Briar, Caroline Bleakley, Aikaterini Vlachou, Melissa Baldwin, Nick Lees, Susanna Price, Stephane Ledot, Colm McCabe, S John Wort, Brijesh V Patel, Laura C Price, Benjamin Garfield, Charles McFadyen, Charlotte Briar, Caroline Bleakley, Aikaterini Vlachou, Melissa Baldwin, Nick Lees, Susanna Price, Stephane Ledot, Colm McCabe, S John Wort, Brijesh V Patel, Laura C Price

No abstract available

Keywords: ARDS; COVID-19; inhaled nitric oxide; pulmonary hypertension; right ventricular dysfunction.

Figures

Fig 1
Fig 1
(a) PaO2/FiO2 (kPa) in the 24 h before and at time points after starting iNO in patients with moderately severe ARDS and Covid-19 infection. There was no significant rebound worsening in the PaO2/FiO2 ratio in the 24 h after stopping iNO. (b) Dead space fraction, defined using Bohr equation with Engelhoff modification, in the 24 h before and at time points after starting iNO in patients with moderately severe ARDS and Covid-19 infection. There was no significant difference between pre stopping and post stopping iNO. Values are average of three measurements at each time point. ∗Denotes a significant difference between this time point and pre-starting iNO. ∗P<0.05; ∗∗P<0.01; ∗∗∗P<0.001. PaO2/FiO2, partial pressure of arterial oxygen/fraction of inspired oxygen; ARDS, acute respiratory distress syndrome; iNO, inhaled nitric oxide. 159×73 mm (300×300 DPI).

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Source: PubMed

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