Sensation and Psychiatry: Linking Age-Related Hearing Loss to Late-Life Depression and Cognitive Decline

Abstract

Recent research has linked age-related hearing loss to impaired performance across cognitive domains and increased risk for dementia diagnosis. The data linking hearing impairment to incident late-life depression are more mixed but suggest that diminished hearing does increase risk for depression. Behavioral mechanisms may explain these associations, such as the withdrawal of older adults from situations in which they may have difficulty hearing and communicating, which may contribute to the development of social isolation, loneliness, and consequent cognitive decline and depression. At a neural level, chronic hearing loss leads to reduced activation in central auditory pathways, resulting in compensatory increased activation in the cognitive control network, dysfunctional auditory-limbic connectivity, and deafferentation-induced atrophy in frontal brain regions. These pathologic changes decrease cognitive performance and increase depression risk by reducing cognitive reserve, increasing executive dysfunction, and disrupting normative emotion reactivity and regulation. Based on the available data and informed by this model, evidence-based suggestions are proposed for clinicians treating older adults, and a research agenda is advanced to facilitate the development of rationally designed and age-appropriate psychiatric treatments for older adults with age-related hearing loss. First and foremost, treating hearing loss should be investigated as a means of improving cognitive and depressive outcomes in well-designed studies incorporating comprehensive psychiatric assessments, randomization, objective documentation of compliance, and analyses of treatment mediators that will facilitate further therapeutic development. Multimodal neuroimaging studies integrating audiometric, neuropsychological, and clinical assessments also are needed to further evaluate the model proposed. [AJP at 175: Remembering Our Past As We Envision Our Future April 1995: Effect of Hearing Enhancement on Medical Status Ratings Twenty-one elderly psychiatric patients had lower levels of psychopathology when assessed while wearing hearing aids. (Am J Psychiatry 1995; 152:629-631 )].

Keywords: Geriatric Psychiatry; cognitive impairment; dementia; depression; hearing impairment.

Conflict of interest statement

Dr. Golub has had travel expenses paid for when attending educational or training events organized by Cochlear. The other authors report no financial relationships with commercial interests.

Figures

FIGURE 1

Clinical and Behavioral Mediators Linking Age-Related Hearing Loss to Neuropsychiatric Dysfunction

FIGURE 2. Putative Causal Mechanisms Linking Age-Related Hearing Loss to Cognitive Decline and Late-Life Depressiona

aA. Degenerative changes associated with age lead to peripheral sensorineural hearing loss. B. Neural mediators include compensatory recruitment of the cognitive control network to support effortful listening (B1), activation changes in limbic regions sharing connectivity with the auditory network (B2), and deafferentation-induced atrophy (B3). C. These acute activation changes and longer-term adverse neoplastic sequelae of hearing loss may lead to executive dysfunction and impaired affective information processing, leading to increased risk of late-life depression and mild cognitive impairment., AC=primary auditory cortex, ACC=anterior cingulate cortex, AMY=amygdala, DLPFC=dorsolateral prefrontal cortex, iFG=inferior frontal gyrus, INS=insula, MGN=medial geniculate nucleus of the thalamus, NAC=nucleus accumbens, PFC=prefrontal cortex, STG=superior temporal gyrus, VS=ventral striatum.

FIGURE 3

Possible Targets of Therapeutic Intervention for Patients With Hearing Loss Who Are at Risk of Neuropsychiatric Dysfunction